TERT-BUTYL (4-NITROBENZYL)CARBAMATE
- Product Name
- TERT-BUTYL (4-NITROBENZYL)CARBAMATE
- CAS No.
- 94838-58-1
- Chemical Name
- TERT-BUTYL (4-NITROBENZYL)CARBAMATE
- Synonyms
- N-Boc-4-nitrobenzylamine;TERT-BUTYL (4-NITROBENZYL)CARBAMATE;2-Methyl-2-propanyl (4-nitrobenzyl)carbamate;tert-butyl N-[(4-nitrophenyl)methyl]carbamate;Carbamic acid, N-[(4-nitrophenyl)methyl]-, 1,1-dimethylethyl ester
- CBNumber
- CB8835552
- Molecular Formula
- C12H16N2O4
- Formula Weight
- 252.27
- MOL File
- 94838-58-1.mol
TERT-BUTYL (4-NITROBENZYL)CARBAMATE Property
- Melting point:
- 105-108 °C
- Boiling point:
- 408.8±28.0 °C(Predicted)
- Density
- 1.187±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- 11.58±0.46(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 8824CR
- Product name
- Tert-Butyl4-nitrobenzylcarbamate
- Packaging
- 1g
- Price
- $195
- Updated
- 2021/12/16
- Product number
- CHM0371106
- Product name
- TERT-BUTYL-(4-NITROBENZYL)CARBAMATE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $496.58
- Updated
- 2021/12/16
- Product number
- 94838581
- Product name
- tert-Butyl(4-nitrobenzyl)carbamate
- Packaging
- 10g
- Price
- $510.34
- Updated
- 2021/12/16
- Product number
- CD12003166
- Product name
- tert-Butyl4-nitrobenzylcarbamate
- Purity
- 95+%
- Packaging
- 5g
- Price
- $221
- Updated
- 2021/12/16
- Product number
- AM-5193
- Product name
- N-Boc-4-nitrobenzylamine
- Purity
- 97%
- Packaging
- 1g
- Price
- $110
- Updated
- 2021/12/16
TERT-BUTYL (4-NITROBENZYL)CARBAMATE Chemical Properties,Usage,Production
Synthesis
24424-99-5
18600-42-5
94838-58-1
Step 1: Preparation of tert-butyl 4-nitrobenzylcarbamate (C4) 4-Nitrobenzylamine hydrochloride (10 g, 53.0 mmol) was suspended in a mixed solvent of THF (150 mL) and water (13 mL) and cooled to 0 °C. Di-tert-butyl dicarbonate (11.6 g, 53.0 mmol) and N,N-diisopropylethylamine (27.7 mL, 159 mmol) were added sequentially under stirring. The reaction mixture was stirred at 0 °C for 30 min and then slowly warmed up to 25 °C and continued stirring for about 20 hours. Upon completion of the reaction, most of the THF was removed by concentration under reduced pressure. the residue was dissolved in EtOAc and washed sequentially with 1N HCl, saturated NaHCO3 solution and saturated NaCl solution. The organic phase was dried over anhydrous MgSO4, filtered and concentrated under reduced pressure to give the off-white solid product C4 (14.0 g, 99% yield). 1H NMR (400 MHz, d6-DMSO) δ: 8.16 (d, 2H), 7.55 (t, 1H), 7.46 (d, 2H), 4.21 (d, 2H), 1.36 (s, 9H).
References
[1] Patent: US2009/54395, 2009, A1. Location in patent: Page/Page column 48
[2] Bioorganic and Medicinal Chemistry Letters, 2003, vol. 13, # 24, p. 4389 - 4393
[3] European Journal of Medicinal Chemistry, 2014, vol. 80, p. 101 - 111
[4] Chemical Communications, 2014, vol. 50, # 97, p. 15305 - 15308
[5] Patent: US2016/264520, 2016, A1. Location in patent: Paragraph 0332; 0333; 0334; 0335
TERT-BUTYL (4-NITROBENZYL)CARBAMATE Preparation Products And Raw materials
Raw materials
Preparation Products
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