2,6-Piperidinedione, 3-(6-fluoro-1,3-dihydro-1-oxo-2H-isoindol-2-yl)-

Product Name: 2,6-Piperidinedione, 3-(6-fluoro-1,3-dihydro-1-oxo-2H-isoindol-2-yl)-
CAS No.: 2468780-87-0
Chemical Name: 2,6-Piperidinedione, 3-(6-fluoro-1,3-dihydro-1-oxo-2H-isoindol-2-yl)-
Synonyms: Lenalidomide-6-F;3-(6-Fluoro-1-oxo-2-isoindolinyl)piperidine-2,6-dione;2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1-oxo-2,3-dihydro-1H-isoindol;3-(6-fluoro-1,3-dihydro-1-oxo-2H-isoindol-2-yl)-2,6-piperidinedione;2,6-Piperidinedione, 3-(6-fluoro-1,3-dihydro-1-oxo-2H-isoindol-2-yl)-
CBNumber: CB88367459
Molecular Formula: C13H11FN2O3
Formula Weight: 262.24
MOL File: 2468780-87-0.mol

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2,6-Piperidinedione, 3-(6-fluoro-1,3-dihydro-1-oxo-2H-isoindol-2-yl)- Property

Boiling point:: 534.5±50.0 °C(Predicted)
Density: 1.461±0.06 g/cm3(Predicted)
storage temp.: Storage temp. 2-8°C
pka: 10.63±0.40(Predicted)
form: Solid
color: Gray to gray purple
InChI: InChI=1S/C13H11FN2O3/c14-8-2-1-7-6-16(13(19)9(7)5-8)10-3-4-11(17)15-12(10)18/h1-2,5,10H,3-4,6H2,(H,15,17,18)
InChIKey: HNAQSGYWVZTYEF-UHFFFAOYSA-N
SMILES: N1C(=O)CCC(N2CC3=C(C2=O)C=C(F)C=C3)C1=O

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Ambeed

Product number: A1469777
Product name: 3-(6-Fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione
Purity: 97%
Packaging: 100mg
Price: $53
Updated: 2021/12/16

Ambeed

Product number: A1469777
Product name: 3-(6-Fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione
Purity: 97%
Packaging: 250mg
Price: $78
Updated: 2021/12/16

Ambeed

Product number: A1469777
Product name: 3-(6-Fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione
Purity: 97%
Packaging: 1g
Price: $191
Updated: 2021/12/16

1Pluschem

Product number: 1P01KCXQ
Product name: 2,6-Piperidinedione, 3-(6-fluoro-1,3-dihydro-1-oxo-2H-isoindol-2-yl)-
Purity: 97%
Packaging: 250mg
Price: $276
Updated: 2021/12/16

1Pluschem

Product number: 1P01KCXQ
Product name: 2,6-Piperidinedione, 3-(6-fluoro-1,3-dihydro-1-oxo-2H-isoindol-2-yl)-
Purity: 97%
Packaging: 5g
Price: $1235
Updated: 2021/12/16

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2,6-Piperidinedione, 3-(6-fluoro-1,3-dihydro-1-oxo-2H-isoindol-2-yl)- Chemical Properties,Usage,Production

Uses

Lenalidomide-6-F is the Lenalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein. Lenalidomide-6-F can be connected to the ligand for protein by a linker to form PROTAC[1].

IC 50

Cereblon

References

[1] Scheepstra M, et al. Bivalent Ligands for Protein Degradation in Drug Discovery. Comput Struct Biotechnol J. 2019;17:160-176. Published 2019 Jan 25. DOI:10.1016/j.csbj.2019.01.006
[2] Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985. DOI:10.7554/eLife.57277

2,6-Piperidinedione, 3-(6-fluoro-1,3-dihydro-1-oxo-2H-isoindol-2-yl)- Preparation Products And Raw materials

Raw materials

Preparation Products

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2,6-Piperidinedione, 3-(6-fluoro-1,3-dihydro-1-oxo-2H-isoindol-2-yl)- Suppliers

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2468780-87-0, 2,6-Piperidinedione, 3-(6-fluoro-1,3-dihydro-1-oxo-2H-isoindol-2-yl)-Related Search:

3-(5,6-difluoro-1,3-dihydro-1-oxo-2H-isoindol-2-yl)-2,6-Piperidinedione 3-(5-Bromo-1-oxoisoindolin-2-yl)piperidine-2,6-dione

2,6-Piperidinedione, 3-(6-fluoro-1,3-dihydro-1-oxo-2H-isoindol-2-yl)-

3-(6-fluoro-1,3-dihydro-1-oxo-2H-isoindol-2-yl)-2,6-piperidinedione

Lenalidomide-6-F

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3-(6-Fluoro-1-oxo-2-isoindolinyl)piperidine-2,6-dione

2468780-87-0

468780-87-0