3-(5-Bromo-1-oxoisoindolin-2-yl)piperidine-2,6-dione

Product Name: 3-(5-Bromo-1-oxoisoindolin-2-yl)piperidine-2,6-dione
CAS No.: 1010100-26-1
Chemical Name: 3-(5-Bromo-1-oxoisoindolin-2-yl)piperidine-2,6-dione
Synonyms: Lenalidomide-5-Br;Bromo-1-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(5-Bromo-1-oxo-2-isoindolinyl)piperidine-2,6-dione;3-(5-Bromo-1-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(6-bromo-3-oxo-1H-isoindol-2-yl)piperidine-2,6-dione;3-bromo-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione;3-(5-bromo-1-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione;3-(5-bromo-1-oxo-3H-isoindol-2-yl)piperidine-2,6-dione - [AC79894];3-(5-bromo-1-oxo-2,3-dihydro-1H-isoindol-2-yl)piperidine-2,6-dione;3-(5-bromo-1,3-dihydro-1-oxo-2h-isoindol-2-yl)-2,6-piperidinedione
CBNumber: CB45427998
Molecular Formula: C13H11BrN2O3
Formula Weight: 323.14
MOL File: 1010100-26-1.mol

More

Less

3-(5-Bromo-1-oxoisoindolin-2-yl)piperidine-2,6-dione Property

Boiling point:: 587.6±50.0 °C(Predicted)
Density: 1.688±0.06 g/cm3(Predicted)
storage temp.: Storage temp. 2-8°C
solubility: DMSO : < 1 mg/mL (ultrasonic;warming;heat to 60°C) (insoluble or slightly soluble)
pka: 10.60±0.40(Predicted)
form: Solid
color: Off-white to gray
InChI: InChI=1S/C13H11BrN2O3/c14-8-1-2-9-7(5-8)6-16(13(9)19)10-3-4-11(17)15-12(10)18/h1-2,5,10H,3-4,6H2,(H,15,17,18)
InChIKey: CMRQAKJTXKOGSF-UHFFFAOYSA-N
SMILES: N1C(=O)CCC(N2CC3=C(C2=O)C=CC(Br)=C3)C1=O

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

TCI Chemical

Product number: B6528
Product name: 3-(5-Bromo-1-oxoisoindolin-2-yl)piperidine-2,6-dione
Packaging: 100MG
Price: $45
Updated: 2025/07/31

TCI Chemical

Product number: B6528
Product name: 3-(5-Bromo-1-oxoisoindolin-2-yl)piperidine-2,6-dione
Packaging: 1G
Price: $204
Updated: 2025/07/31

AK Scientific

Product number: 9194DT
Product name: 3-(5-Bromo-1-oxoisoindolin-2-yl)piperidine-2,6-dione
Packaging: 1g
Price: $1342
Updated: 2021/12/16

Ambeed

Product number: A1226590
Product name: 3-(5-Bromo-1-oxoisoindolin-2-yl)piperidine-2,6-dione
Purity: 98%
Packaging: 100mg
Price: $52
Updated: 2021/12/16

Aaron Chemicals

Product number: AR01JMHX
Product name: 3-(5-Bromo-1-oxoisoindolin-2-yl)piperidine-2,6-dione
Purity: 97%
Packaging: 100mg
Price: $127
Updated: 2021/12/16

More

Less

3-(5-Bromo-1-oxoisoindolin-2-yl)piperidine-2,6-dione Chemical Properties,Usage,Production

Description

3-(5-Bromo-1-oxo-2-isoindolinyl)piperidine-2,6-dione is a lenalidomide analog that can be useful in PROTAC research because it is applicable to the recruitment of CRBN protein.

Uses

Lenalidomide-5-Br is the Lenalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein. Lenalidomide-5-Br can be connected to the ligand for protein by a linker to form PROTAC[1].

IC 50

Cereblon

References

[1] Scheepstra M, et al. Bivalent Ligands for Protein Degradation in Drug Discovery. Comput Struct Biotechnol J. 2019;17:160-176. Published 2019 Jan 25. DOI:10.1016/j.csbj.2019.01.006
[2] Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985. DOI:10.7554/eLife.57277

3-(5-Bromo-1-oxoisoindolin-2-yl)piperidine-2,6-dione Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

3-(5-Bromo-1-oxoisoindolin-2-yl)piperidine-2,6-dione Suppliers

China 106 United States 4 Global 110

Jilin Province Woda Biotechnology Co., Ltd.

Tel: 13504435624
Email: 1927928688@qq.com
Country: China
ProdList: 1615
Advantage: 58

Amatek Scientific Co. Ltd.

Tel: 0512-56316828
Fax: 0512-56316826
Email: info@amateksci.com
Country: China
ProdList: 28785
Advantage: 58

Aikon International Limited

Tel: 025-58859352 18068836627
Fax: 02557626880
Email: sales01@aikonchem.com
Country: China
ProdList: 16027
Advantage: 58

Henan Mengtai Pharmaceutical Technology Co., Ltd

Tel: 176345344 7 17634854698
Email: 1959525201@qq.com
Country: China
ProdList: 10000
Advantage: 58

Shaoyuan Technology (Shanghai) Co., Ltd.

Tel: 021-50795510 4000665055
Email: sy-c5@accelachem.com
Country: China
ProdList: 10000
Advantage: 58

Beijing HwrkChemical Technology Co., Ltd

Tel: 18515581800 18501085097
Fax: 010-89508210
Email: sales.bj@hwrkchemical.com
Country: China
ProdList: 9400
Advantage: 55

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44801
Advantage: 61

Changzhou Huanling Chemical Co., Ltd.

Tel: 0519-89803565 13776850645
Fax: 0519-89803575
Email: info4@huanlingchem.com
Country: China
ProdList: 891
Advantage: 68

Nanjing Chemlin Chemical Co., Ltd

Tel: 025-83697070
Fax: +86-25-83453306
Email: info@chemlin.com.cn
Country: China
ProdList: 15883
Advantage: 64

Daicel Chiral Technologies (China)CO.,LTD

Tel: 021-50460086-9 15921403865
Fax: +86-21-50462321
Email: han_yajun@dctc.daicel.com
Country: China
ProdList: 7471
Advantage: 65

More

Less

View Lastest Price from 3-(5-Bromo-1-oxoisoindolin-2-yl)piperidine-2,6-dione manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: 3-(5-Bromo-1-oxoisoindolin-2-yl)piperidine-2,6-dione 1010100-26-1
Price: US $0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1000kg
Release date: 2025-06-19

1010100-26-1, 3-(5-Bromo-1-oxoisoindolin-2-yl)piperidine-2,6-dioneRelated Search:

2,6-Piperidinedione, 3-(6-fluoro-1,3-dihydro-1-oxo-2H-isoindol-2-yl)- 3-(5,6-difluoro-1,3-dihydro-1-oxo-2H-isoindol-2-yl)-2,6-Piperidinedione 3-(4-bromo-1-oxoisoindolin-2-yl)piperidine-2,6-dione

3-(5-Bromo-1-oxoisoindolin-2-yl)piperidine-2,6-dione

2,6-Piperidinedione, 3-(5-bromo-1,3-dihydro-1-oxo-2H-isoindol-2-yl)-

3-bromo-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione

3-(5-Bromo-1-oxo-2-isoindolinyl)piperidine-2,6-dione

3-(5-bromo-1,3-dihydro-1-oxo-2h-isoindol-2-yl)-2,6-piperidinedione

Lenalidomide-5-Br

3-(5-bromo-1-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione

3-(5-bromo-1-oxo-2,3-dihydro-1H-isoindol-2-yl)piperidine-2,6-dione

3-(6-bromo-3-oxo-1H-isoindol-2-yl)piperidine-2,6-dione

Bromo-1-oxoisoindolin-2-yl)piperidine-2,6-dione

3-(5-bromo-1-oxo-3H-isoindol-2-yl)piperidine-2,6-dione - [AC79894]

1010100-26-1

E3 ligase Ligan