3-(4-bromo-1-oxoisoindolin-2-yl)piperidine-2,6-dione

Product Name: 3-(4-bromo-1-oxoisoindolin-2-yl)piperidine-2,6-dione
CAS No.: 2093387-36-9
Chemical Name: 3-(4-bromo-1-oxoisoindolin-2-yl)piperidine-2,6-dione
Synonyms: 3-(4-bromo-1-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(7-bromo-3-oxo-1H-isoindol-2-yl)piperidine-2,6-dione;3-(4-bromo-1-oxo-isoindolin-2-yl)piperidine-2,6-dione - [B84704];3-(4-bromo-1-oxo-2,3-dihydro-1H-isoindol-2-yl)piperidine-2,6-dione;3-(4-bromo-1-oxo-1,3-dihydro-2H-isoindol-2-yl)piperidine-2,6-dione;2,6-Piperidinedione, 3-(4-bromo-1,3-dihydro-1-oxo-2H-isoindol-2-yl)-;3-(4-bromo-1-oxo-2,3-dihydro-1H-isoindol-2-yl)hexahydropyridine-2,6-dione;Ligands for E3 Ligase,analog,Inhibitor,recruitment,ubiquitin,inhibit,LenalidomideBr,Lenalidomide-Br,E3 ligase-recruiting Moiety,cereblon,Lenalidomide Br,ligase,protein,PROTAC
CBNumber: CB94881455
Molecular Formula: C13H11BrN2O3
Formula Weight: 323.14
MOL File: 2093387-36-9.mol

More

Less

3-(4-bromo-1-oxoisoindolin-2-yl)piperidine-2,6-dione Property

Boiling point:: 588.0±50.0 °C(Predicted)
Density: 1.688±0.06 g/cm3(Predicted)
storage temp.: Storage temp. 2-8°C
pka: 10?+-.0.40(Predicted)
form: Solid
color: Pale purple to purple
InChI: InChI=1S/C13H11BrN2O3/c14-9-3-1-2-7-8(9)6-16(13(7)19)10-4-5-11(17)15-12(10)18/h1-3,10H,4-6H2,(H,15,17,18)
InChIKey: SCZFMUWTABGOGF-UHFFFAOYSA-N
SMILES: N1C(=O)CCC(N2CC3=C(C2=O)C=CC=C3Br)C1=O

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

TCI Chemical

Product number: B6546
Product name: 3-(4-Bromo-1-oxoisoindolin-2-yl)piperidine-2,6-dione
Packaging: 200MG
Price: $50
Updated: 2025/07/31

TCI Chemical

Product number: B6546
Product name: 3-(4-Bromo-1-oxoisoindolin-2-yl)piperidine-2,6-dione
Packaging: 1G
Price: $150
Updated: 2025/07/31

AK Scientific

Product number: 2866EL
Product name: 3-(4-Bromo-1-oxoisoindolin-2-yl)piperidine-2,6-dione
Packaging: 1g
Price: $1268
Updated: 2021/12/16

Alichem

Product number: 2093387369
Product name: 3-(4-Bromo-1-oxoisoindolin-2-yl)piperidine-2,6-dione
Packaging: 1g
Price: $1590
Updated: 2021/12/16

DC Chemicals

Product number: 020577
Product name: Lenalidomide-Br
Packaging: 003
Price: $2100
Updated: 2021/12/16

More

Less

3-(4-bromo-1-oxoisoindolin-2-yl)piperidine-2,6-dione Chemical Properties,Usage,Production

Description

3-(4-Bromo-1-oxoisoindolin-2-yl)piperidine-2,6-dione is a lenalidomide analog that can be useful in PROTAC research because it is applicable to the recruitment of CRBN protein.

Uses

Lenalidomide-Br (Compound 41) is an analog of cereblon (CRBN) ligand Lenalidomide for E3 ubiquitin ligase, and is used in the recruitment of CRBN protein. Lenalidomide-Br can be connected to the ligand for protein by a linker to form PROTACs, such as the PROTAC STAT3 degrader SD-36 (HY-129602)[1][2].

IC 50

Cereblon

References

[1] Bai L, et al. A Potent and Selective Small-Molecule Degrader of STAT3 Achieves Complete Tumor Regression In Vivo. Cancer Cell. 2019 Nov 11;36(5):498-511.e17. DOI:10.1016/j.ccell.2019.10.002
[2] Zhou B, et al. Discovery of a Small-Molecule Degrader of Bromodomain and Extra-Terminal (BET) Proteins with Picomolar Cellular Potencies and Capable of Achieving Tumor Regression. J Med Chem. 2018 Jan 25;61(2):462-481. DOI:10.1021/acs.jmedchem.6b01816

3-(4-bromo-1-oxoisoindolin-2-yl)piperidine-2,6-dione Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

3-(4-bromo-1-oxoisoindolin-2-yl)piperidine-2,6-dione Suppliers

China 91 United States 3 Global 94

Jilin Province Woda Biotechnology Co., Ltd.

Tel: 13504435624
Email: 1927928688@qq.com
Country: China
ProdList: 1615
Advantage: 58

Amatek Scientific Co. Ltd.

Tel: 0512-56316828
Fax: 0512-56316826
Email: info@amateksci.com
Country: China
ProdList: 28785
Advantage: 58

Shanghai Moss Medicine Technology Co., Ltd.

Tel: +86-188369842 +86-15618151133
Fax: QQ188369842
Email: 188369842@qq.com
Country: China
ProdList: 1959
Advantage: 58

Jiangsu aikang biomedical research and development co., LTD

Tel: 025-58859352 13155353615
Email: qzhang@aikonchem.com
Country: China
ProdList: 15525
Advantage: 58

SuZhou Medinoah Co.,LTD.

Tel: 0512-69561983 13914027025
Fax: 0512-69561982
Email: zhang_q@medinoah.com
Country: China
ProdList: 3811
Advantage: 58

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44801
Advantage: 61

Accela ChemBio Co.,Ltd.

Tel: 021-50795510 4000665055
Fax: 021-50795055
Email: sales@accelachem.com
Country: China
ProdList: 11035
Advantage: 64

Daicel Chiral Technologies (China)CO.,LTD

Tel: 021-50460086-9 15921403865
Fax: +86-21-50462321
Email: han_yajun@dctc.daicel.com
Country: China
ProdList: 7471
Advantage: 65

Shanghai Topbiochem Technology Co., Ltd

Tel: 021-58170097
Email: info@topbiochem.com
Country: China
ProdList: 9510
Advantage: 58

Shanghai Leto Pharmatech Co.,Ltd.

Tel: 18016401466
Fax: QQ: 1375988926
Email: sales@letopharm.com
Country: China
ProdList: 245
Advantage: 58

More

Less

View Lastest Price from 3-(4-bromo-1-oxoisoindolin-2-yl)piperidine-2,6-dione manufacturers

Career Henan Chemical Co

Product: 4,6,7-Trimethoxyindole 2093387-36-9
Price: US $1.00/KG
Min. Order: 1KG
Purity: 85.0-99.8%
Supply Ability: 20 tons
Release date: 2019-12-23

2093387-36-9, 3-(4-bromo-1-oxoisoindolin-2-yl)piperidine-2,6-dioneRelated Search:

3-(5-Bromo-1-oxoisoindolin-2-yl)piperidine-2,6-dione

3-(4-bromo-1-oxoisoindolin-2-yl)piperidine-2,6-dione

3-(4-bromo-1-oxo-2,3-dihydro-1H-isoindol-2-yl)piperidine-2,6-dione

2,6-Piperidinedione, 3-(4-bromo-1,3-dihydro-1-oxo-2H-isoindol-2-yl)-

3-(4-bromo-1-oxo-1,3-dihydro-2H-isoindol-2-yl)piperidine-2,6-dione

Ligands for E3 Ligase,analog,Inhibitor,recruitment,ubiquitin,inhibit,LenalidomideBr,Lenalidomide-Br,E3 ligase-recruiting Moiety,cereblon,Lenalidomide Br,ligase,protein,PROTAC

3-(7-bromo-3-oxo-1H-isoindol-2-yl)piperidine-2,6-dione

3-(4-bromo-1-oxo-isoindolin-2-yl)piperidine-2,6-dione - [B84704]

3-(4-bromo-1-oxo-2,3-dihydro-1H-isoindol-2-yl)hexahydropyridine-2,6-dione

2093387-36-9

E3 ligase Ligan