ChemicalBook > CAS DataBase List > 3-(4-bromo-1-oxoisoindolin-2-yl)piperidine-2,6-dione

3-(4-bromo-1-oxoisoindolin-2-yl)piperidine-2,6-dione

Product Name
3-(4-bromo-1-oxoisoindolin-2-yl)piperidine-2,6-dione
CAS No.
2093387-36-9
Chemical Name
3-(4-bromo-1-oxoisoindolin-2-yl)piperidine-2,6-dione
Synonyms
3-(4-bromo-1-oxoisoindolin-2-yl)piperidine-2,6-dione;3-(7-bromo-3-oxo-1H-isoindol-2-yl)piperidine-2,6-dione;3-(4-bromo-1-oxo-isoindolin-2-yl)piperidine-2,6-dione - [B84704];3-(4-bromo-1-oxo-2,3-dihydro-1H-isoindol-2-yl)piperidine-2,6-dione;3-(4-bromo-1-oxo-1,3-dihydro-2H-isoindol-2-yl)piperidine-2,6-dione;2,6-Piperidinedione, 3-(4-bromo-1,3-dihydro-1-oxo-2H-isoindol-2-yl)-;3-(4-bromo-1-oxo-2,3-dihydro-1H-isoindol-2-yl)hexahydropyridine-2,6-dione;Ligands for E3 Ligase,analog,Inhibitor,recruitment,ubiquitin,inhibit,LenalidomideBr,Lenalidomide-Br,E3 ligase-recruiting Moiety,cereblon,Lenalidomide Br,ligase,protein,PROTAC
CBNumber
CB94881455
Molecular Formula
C13H11BrN2O3
Formula Weight
323.14
MOL File
2093387-36-9.mol
More
Less

3-(4-bromo-1-oxoisoindolin-2-yl)piperidine-2,6-dione Property

Boiling point:
588.0±50.0 °C(Predicted)
Density 
1.688±0.06 g/cm3(Predicted)
storage temp. 
Storage temp. 2-8°C
pka
10?+-.0.40(Predicted)
form 
Solid
color 
Pale purple to purple
InChI
InChI=1S/C13H11BrN2O3/c14-9-3-1-2-7-8(9)6-16(13(7)19)10-4-5-11(17)15-12(10)18/h1-3,10H,4-6H2,(H,15,17,18)
InChIKey
SCZFMUWTABGOGF-UHFFFAOYSA-N
SMILES
N1C(=O)CCC(N2CC3=C(C2=O)C=CC=C3Br)C1=O
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

TCI Chemical
Product number
B6546
Product name
3-(4-Bromo-1-oxoisoindolin-2-yl)piperidine-2,6-dione
Packaging
200MG
Price
$50
Updated
2025/07/31
TCI Chemical
Product number
B6546
Product name
3-(4-Bromo-1-oxoisoindolin-2-yl)piperidine-2,6-dione
Packaging
1G
Price
$150
Updated
2025/07/31
AK Scientific
Product number
2866EL
Product name
3-(4-Bromo-1-oxoisoindolin-2-yl)piperidine-2,6-dione
Packaging
1g
Price
$1268
Updated
2021/12/16
DC Chemicals
Product number
020577
Product name
Lenalidomide-Br
Packaging
001
Price
$600
Updated
2021/12/16
Acrotein
Product number
AS01332
Product name
3-(4-Bromo-1-oxoisoindolin-2-yl)piperidine-2,6-dione
Purity
97%
Packaging
5g
Price
$1100
Updated
2021/12/16
More
Less

3-(4-bromo-1-oxoisoindolin-2-yl)piperidine-2,6-dione Chemical Properties,Usage,Production

Description

3-(4-Bromo-1-oxoisoindolin-2-yl)piperidine-2,6-dione is a lenalidomide analog that can be useful in PROTAC research because it is applicable to the recruitment of CRBN protein.

Uses

Lenalidomide-Br (Compound 41) is an analog of cereblon (CRBN) ligand Lenalidomide for E3 ubiquitin ligase, and is used in the recruitment of CRBN protein. Lenalidomide-Br can be connected to the ligand for protein by a linker to form PROTACs, such as the PROTAC STAT3 degrader SD-36 (HY-129602)[1][2].

IC 50

Cereblon

References

[1] Bai L, et al. A Potent and Selective Small-Molecule Degrader of STAT3 Achieves Complete Tumor Regression In Vivo. Cancer Cell. 2019 Nov 11;36(5):498-511.e17. DOI:10.1016/j.ccell.2019.10.002
[2] Zhou B, et al. Discovery of a Small-Molecule Degrader of Bromodomain and Extra-Terminal (BET) Proteins with Picomolar Cellular Potencies and Capable of Achieving Tumor Regression. J Med Chem. 2018 Jan 25;61(2):462-481. DOI:10.1021/acs.jmedchem.6b01816

3-(4-bromo-1-oxoisoindolin-2-yl)piperidine-2,6-dione Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

3-(4-bromo-1-oxoisoindolin-2-yl)piperidine-2,6-dione Suppliers

China 91 United States 3 Global 94
Jilin Province Woda Biotechnology Co., Ltd.
Tel
13504435624
Email
1927928688@qq.com
Country
China
ProdList
1615
Advantage
58
Amatek Scientific Co. Ltd.
Tel
0512-56316828
Fax
0512-56316826
Email
info@amateksci.com
Country
China
ProdList
28785
Advantage
58
Shanghai Moss Medicine Technology Co., Ltd.
Tel
+86-188369842 +86-15618151133
Fax
QQ188369842
Email
188369842@qq.com
Country
China
ProdList
1959
Advantage
58
Jiangsu aikang biomedical research and development co., LTD
Tel
025-58859352 13155353615
Email
qzhang@aikonchem.com
Country
China
ProdList
15525
Advantage
58
SuZhou Medinoah Co.,LTD.
Tel
0512-69561983 13914027025
Fax
0512-69561982
Email
zhang_q@medinoah.com
Country
China
ProdList
3811
Advantage
58
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44801
Advantage
61
Accela ChemBio Co.,Ltd.
Tel
021-50795510 4000665055
Fax
021-50795055
Email
sales@accelachem.com
Country
China
ProdList
11035
Advantage
64
Daicel Chiral Technologies (China)CO.,LTD
Tel
021-50460086-9 15921403865
Fax
+86-21-50462321
Email
han_yajun@dctc.daicel.com
Country
China
ProdList
7471
Advantage
65
Shanghai Topbiochem Technology Co., Ltd
Tel
021-58170097
Email
info@topbiochem.com
Country
China
ProdList
9510
Advantage
58
Shanghai Leto Pharmatech Co.,Ltd.
Tel
18016401466
Fax
QQ: 1375988926
Email
sales@letopharm.com
Country
China
ProdList
245
Advantage
58
Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696，15000506266 15000506266
Fax
+86-21-52996696
Country
China
ProdList
4768
Advantage
55
Shanghai Synchem Pharma Co., ltd
Tel
21-619849051-1 18521059765
Email
synchempharma@aliyun.com
Country
China
ProdList
6468
Advantage
55
ShangHai Angti Biotechnology Co., Ltd.
Tel
13764913901
Fax
-
Email
info@angtibio.com
Country
China
ProdList
4981
Advantage
55
Shanghai Toplab Chemical Co., Ltd.
Tel
021-31137757-00; 18121466954
Fax
021-64902762
Email
28328681@qq.com
Country
China
ProdList
180
Advantage
55
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
71826
Advantage
60
Chengdu Xiaojia Technology Co., Ltd.
Tel
15902830537
Email
zhanghao@happysyn.com
Country
China
ProdList
3180
Advantage
55
Jiaxing Deyi Chemical Co., Ltd.
Tel
86-0573-85866609 13325730825
Fax
0573-85866609
Email
945717149@qq.com
Country
China
ProdList
8595
Advantage
58
Nanjing Daqin Pharmaceutical Technology Co., Ltd.
Tel
025-025-58470199 18351831988
Fax
025-58470199
Email
sales@daqinpharma.cn
Country
China
ProdList
312
Advantage
58
Nanjing Pope Bio-tech R&D Co., Ltd
Tel
025-87138562
Email
sales@popebiotech.com
Country
China
ProdList
413
Advantage
58
Allfluoro pharmaceutical co. ltd.
Tel
+86-400-0216110 +86-15958047586
Fax
0086-21-33275002
Email
sales@allfluoro.com
Country
China
ProdList
11385
Advantage
58
Zhejiang J&C Biological Technology Co.,Limited
Tel
+1-2135480471
Email
sales@sarms4muscle.com
Country
China
ProdList
10473
Advantage
58
Shanxi Xuanran Import and Export Trade Co., Ltd.
Tel
+8617735180244
Email
mike_yan@xuanranglobal.com
Country
CHINA
ProdList
4017
Advantage
58
Jinan Ruisi Pharmaceutical Technology Co., LTD
Tel
0531-0531-69900633 19963472814
Email
changyuan20@163.com
Country
China
ProdList
2742
Advantage
58
Wuhan Ruilida Biomedical Technology Co., Ltd.
Tel
18201884268
Email
magean83@163.com
Country
China
ProdList
1960
Advantage
58
Shanghai Worldyang Chemical Co.,Ltd.
Tel
+86-021-56795779 +8613651600618
Email
sales@worldyachem.com
Country
China
ProdList
969
Advantage
58
Ningbo Benkang jishi Pharmaceutical Technology Co., Ltd.
Tel
15990591583
Fax
qq: 1050376806 mailbox : sales@nbpharmabridge.com
Country
China
ProdList
6108
Advantage
58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
Tel
18818260767
Fax
QQ 3610331285
Email
sales@chemegen.com
Country
China
ProdList
11218
Advantage
58
Nanjing Bestfluorodrug Pharmaceutical Technology CO.,LTD
Tel
025-86755008 17751752005
Fax
025-86755228
Email
hszhang@bestfluorodrug.com
Country
China
ProdList
2358
Advantage
58
career henan chemical co
Tel
+86-0371-86658258 +8613203830695
Fax
0086-371-86658258
Email
factory@coreychem.com
Country
China
ProdList
29798
Advantage
58
Shanghai hongqu biomedical technology co. LTD
Tel
88888888888
Email
hongquchem@qq.com
Country
China
ProdList
5132
Advantage
58
Beijing Aomi Jiade Pharmaceutical Technology Co., Ltd
Tel
+86-13522808617
Email
omichem@126.com
Country
China
ProdList
6413
Advantage
58
Zhengzhou Convergence Chemical Co. LTD
Tel
0371-0371-53736046 13393710386
Fax
QQ:2853979814
Email
2853979814@qq.com
Country
China
ProdList
9948
Advantage
58
Shanghai Sunway Pharmaceutical Technology Co.,Ltd.
Tel
021-51816796-820 13611835272
Fax
021-5161 3951
Email
sales2@sunwaypharm.com
Country
China
ProdList
44119
Advantage
58
Shanghai Chino Pharmaceutical Technology Co., Ltd
Tel
021-021-51557188 15901710861
Fax
QQ: 569058060
Email
sales@channelpharm.com
Country
China
ProdList
1228
Advantage
58
Jilin Chinese Academy of Sciences - Yanshen Technology Co., Ltd
Tel
0431-80514535 19917294565
Email
ET-market@chemextension.com
Country
China
ProdList
4671
Advantage
58
Beijing Jin Ming Biotechnology Co., Ltd.
Tel
010-60605840 15801484223;
Email
psaitong@jm-bio.com
Country
China
ProdList
29757
Advantage
58
Shaanxi Dideu Medichem Co. Ltd
Tel
029-81124267 17392282731
Fax
029-88380327
Email
1073@dideu.com
Country
China
ProdList
9992
Advantage
58
Nanjing Yili Biotechnology Co., Ltd.
Tel
15380789538
Email
2885743537@qq.com
Country
China
ProdList
8205
Advantage
58
Shanghai Haohong Pharmaceutical Co., Ltd.
Tel
400-8210725 4008210725
Email
malulu@leyan.com
Country
China
ProdList
40000
Advantage
58
PharmaBlock Sciences (Nanjing), Inc.
Tel
4000255188
Fax
025 86918232
Email
sales_china@pharmablock.com
Country
China
ProdList
10000
Advantage
58
Bide Pharmatech Ltd.
Tel
400-1647117 13681763483
Email
product02@bidepharm.com
Country
China
ProdList
59936
Advantage
58
Affinity（Wuhan）Ltd.
Tel
15841022315
Email
sales@affinitytech.cn
Country
China
ProdList
3000
Advantage
58
Shandong Mingde Biotechnology Co., Ltd
Tel
15553348166
Email
m15553348166@163.com
Country
China
ProdList
9967
Advantage
58
TargetMol Chemicals Inc.
Tel
4008200310
Email
marketing@tsbiochem.com
Country
China
ProdList
24961
Advantage
58
Shanghai Maclean Biochemical Technology Co., LTD
Tel
021-021-50706066 15221275939
Email
shenlinxing@macklin.cn
Country
China
ProdList
29784
Advantage
58
Wuhan Yuxiang Medical Technology Co., Ltd.
Tel
13971275651
Email
sales@whyxpharma.com
Country
China
ProdList
1788
Advantage
58
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
18621169109
Email
market03@meryer.com
Country
China
ProdList
27987
Advantage
58
ShenZhen Trendseen Biological Technology Co.,Ltd.
Tel
13417589054;
Email
trendseenbio@gmail.com
Country
China
ProdList
9069
Advantage
58
Shanghai Jianchao Biotechnology Co., LTD
Tel
15021035486 18081542813
Email
1804873256@qq.com
Country
China
ProdList
6684
Advantage
58
Shaanxi PharmaGHS Science Co., LTD
Tel
13279368192
Email
pharmaghs@126.com
Country
China
ProdList
2935
Advantage
58
More
Less

View Lastest Price from 3-(4-bromo-1-oxoisoindolin-2-yl)piperidine-2,6-dione manufacturers

Career Henan Chemical Co
Product
4,6,7-Trimethoxyindole 2093387-36-9
Price
US $1.00/KG
Min. Order
1KG
Purity
85.0-99.8%
Supply Ability
20 tons
Release date
2019-12-23

2093387-36-9, 3-(4-bromo-1-oxoisoindolin-2-yl)piperidine-2,6-dioneRelated Search:

3-(5-Bromo-1-oxoisoindolin-2-yl)piperidine-2,6-dione

  • 3-(4-bromo-1-oxoisoindolin-2-yl)piperidine-2,6-dione
  • 3-(4-bromo-1-oxo-2,3-dihydro-1H-isoindol-2-yl)piperidine-2,6-dione
  • 2,6-Piperidinedione, 3-(4-bromo-1,3-dihydro-1-oxo-2H-isoindol-2-yl)-
  • 3-(4-bromo-1-oxo-1,3-dihydro-2H-isoindol-2-yl)piperidine-2,6-dione
  • Ligands for E3 Ligase,analog,Inhibitor,recruitment,ubiquitin,inhibit,LenalidomideBr,Lenalidomide-Br,E3 ligase-recruiting Moiety,cereblon,Lenalidomide Br,ligase,protein,PROTAC
  • 3-(7-bromo-3-oxo-1H-isoindol-2-yl)piperidine-2,6-dione
  • 3-(4-bromo-1-oxo-isoindolin-2-yl)piperidine-2,6-dione - [B84704]
  • 3-(4-bromo-1-oxo-2,3-dihydro-1H-isoindol-2-yl)hexahydropyridine-2,6-dione
  • 2093387-36-9
  • E3 ligase Ligan