2,6-Piperidinedione, 3-(6-fluoro-1,3-dihydro-1-oxo-2H-isoindol-2-yl)-
- Product Name
- 2,6-Piperidinedione, 3-(6-fluoro-1,3-dihydro-1-oxo-2H-isoindol-2-yl)-
- CAS No.
- 2468780-87-0
- Chemical Name
- 2,6-Piperidinedione, 3-(6-fluoro-1,3-dihydro-1-oxo-2H-isoindol-2-yl)-
- Synonyms
- Lenalidomide-6-F;3-(6-Fluoro-1-oxo-2-isoindolinyl)piperidine-2,6-dione;2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1-oxo-2,3-dihydro-1H-isoindol;3-(6-fluoro-1,3-dihydro-1-oxo-2H-isoindol-2-yl)-2,6-piperidinedione;2,6-Piperidinedione, 3-(6-fluoro-1,3-dihydro-1-oxo-2H-isoindol-2-yl)-
- CBNumber
- CB88367459
- Molecular Formula
- C13H11FN2O3
- Formula Weight
- 262.24
- MOL File
- 2468780-87-0.mol
2,6-Piperidinedione, 3-(6-fluoro-1,3-dihydro-1-oxo-2H-isoindol-2-yl)- Property
- Boiling point:
- 534.5±50.0 °C(Predicted)
- Density
- 1.461±0.06 g/cm3(Predicted)
- storage temp.
- Storage temp. 2-8°C
- pka
- 10.63±0.40(Predicted)
- form
- Solid
- color
- Gray to gray purple
- InChI
- InChI=1S/C13H11FN2O3/c14-8-2-1-7-6-16(13(19)9(7)5-8)10-3-4-11(17)15-12(10)18/h1-2,5,10H,3-4,6H2,(H,15,17,18)
- InChIKey
- HNAQSGYWVZTYEF-UHFFFAOYSA-N
- SMILES
- N1C(=O)CCC(N2CC3=C(C2=O)C=C(F)C=C3)C1=O
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- A1469777
- Product name
- 3-(6-Fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione
- Purity
- 97%
- Packaging
- 100mg
- Price
- $53
- Updated
- 2021/12/16
- Product number
- A1469777
- Product name
- 3-(6-Fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione
- Purity
- 97%
- Packaging
- 250mg
- Price
- $78
- Updated
- 2021/12/16
- Product number
- A1469777
- Product name
- 3-(6-Fluoro-1-oxoisoindolin-2-yl)piperidine-2,6-dione
- Purity
- 97%
- Packaging
- 1g
- Price
- $191
- Updated
- 2021/12/16
- Product number
- 1P01KCXQ
- Product name
- 2,6-Piperidinedione, 3-(6-fluoro-1,3-dihydro-1-oxo-2H-isoindol-2-yl)-
- Purity
- 97%
- Packaging
- 250mg
- Price
- $276
- Updated
- 2021/12/16
- Product number
- 1P01KCXQ
- Product name
- 2,6-Piperidinedione, 3-(6-fluoro-1,3-dihydro-1-oxo-2H-isoindol-2-yl)-
- Purity
- 97%
- Packaging
- 5g
- Price
- $1235
- Updated
- 2021/12/16
2,6-Piperidinedione, 3-(6-fluoro-1,3-dihydro-1-oxo-2H-isoindol-2-yl)- Chemical Properties,Usage,Production
Uses
Lenalidomide-6-F is the Lenalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein. Lenalidomide-6-F can be connected to the ligand for protein by a linker to form PROTAC[1].
IC 50
Cereblon
References
[1] Scheepstra M, et al. Bivalent Ligands for Protein Degradation in Drug Discovery. Comput Struct Biotechnol J. 2019;17:160-176. Published 2019 Jan 25. DOI:10.1016/j.csbj.2019.01.006
[2] Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985. DOI:10.7554/eLife.57277
2,6-Piperidinedione, 3-(6-fluoro-1,3-dihydro-1-oxo-2H-isoindol-2-yl)- Preparation Products And Raw materials
Raw materials
Preparation Products
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