6-Chloro-2,3-diaminotoluene
- Product Name
- 6-Chloro-2,3-diaminotoluene
- CAS No.
- 673487-36-0
- Chemical Name
- 6-Chloro-2,3-diaminotoluene
- Synonyms
- Phloroglucinol Impurity 241;6-CHLORO-2,3-DIAMINOTOLUENE;4-Chloro-3-Methylbenzene-1,2-diaMine;1,2-Benzenediamine, 4-chloro-3-methyl-
- CBNumber
- CB8837804
- Molecular Formula
- C7H9ClN2
- Formula Weight
- 156.61
- MOL File
- 673487-36-0.mol
6-Chloro-2,3-diaminotoluene Property
- Melting point:
- 46-47 °C(Solv: benzene (71-43-2); ligroine (8032-32-4))
- Boiling point:
- 305.6±37.0 °C(Predicted)
- Density
- 1.281±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C, protect from light
- pka
- 3.65±0.10(Predicted)
- Appearance
- Brown to reddish brown Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- C363775
- Product name
- 6-Chloro-2,3-diaminotoluene
- Packaging
- 250mg
- Price
- $95
- Updated
- 2021/12/16
- Product number
- 134507
- Product name
- 4-Chloro-3-methylbenzene-1,2-diamine
- Purity
- 95%+
- Packaging
- 100mg
- Price
- $98
- Updated
- 2021/12/16
- Product number
- Z5017
- Product name
- 4-Chloro-3-methylbenzene-1,2-diamine
- Packaging
- 1g
- Price
- $147
- Updated
- 2021/12/16
- Product number
- 134507
- Product name
- 4-Chloro-3-methylbenzene-1,2-diamine
- Purity
- 95%+
- Packaging
- 500mg
- Price
- $281
- Updated
- 2021/12/16
- Product number
- HCH0105375
- Product name
- 6-CHLORO-2,3-DIAMINOTOLUENE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $499.79
- Updated
- 2021/12/16
6-Chloro-2,3-diaminotoluene Chemical Properties,Usage,Production
Uses
6-Chloro-2,3-diaminotoluene is a white solid powder at room temperature and pressure, with significant alkalinity and strong nucleophilicity. Due to the presence of two amino units in the ortho position of the benzene ring, it can undergo condensation reactions with aldehydes to prepare corresponding benzimidazole derivatives. This reaction is widely used to prepare benzimidazole drugs and bioactive molecules. It is an intermediate in organic synthesis and medicinal chemistry, such as Nemonapride.
Synthesis
A solution of 3-chloro-2-methyl-6-nitroaniline in a mixture of acetic acid and water was heated to 90 ??C, to which iron powder was added. The resulting reaction mixture was further heated at 90 ??C for 2 hours. At the end of the reaction the reaction mixture was cooled to room temperature and poured into ice, then the pH was adjusted to 8 and ethyl acetate was added to the reaction mixture. The resulting mixture was filtered and the organic phase was separated, the resulting organic layer was dried with anhydrous sodium sulfate, filtered to remove the desiccant and the resulting filtrate was concentrated under vacuum. The resulting residue was purified by column chromatography on silica gel, eluting with pentane:ethyl acetate to give 6-chloro-2,3-diaminotoluene.
6-Chloro-2,3-diaminotoluene Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 6-Chloro-2,3-diaminotoluene manufacturers
- Product
- 4-Chloro-3-methylbenzene-1,2-diamine 673487-36-0
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1000kg
- Release date
- 2025-11-07
- Product
- 6-Chloro-2,3-diaminotoluene 673487-36-0
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 10000KGS
- Release date
- 2025-07-18
- Product
- Daridorexant Impurity 673487-36-0
- Price
- US $0.00-0.00/mg
- Min. Order
- 10mg
- Purity
- 99%+ HPLC
- Supply Ability
- 1000
- Release date
- 2025-06-27