4,5,6,7-Tetrahydro-5α-methyl-6-(3-methyl-2-butenyl)-8-chloroimidazo[4,5,1-jk][1,4]benzodiazepine-2(1H)-thione

Product Name: 4,5,6,7-Tetrahydro-5α-methyl-6-(3-methyl-2-butenyl)-8-chloroimidazo[4,5,1-jk][1,4]benzodiazepine-2(1H)-thione
CAS No.: 137332-54-8
Chemical Name: 4,5,6,7-Tetrahydro-5α-methyl-6-(3-methyl-2-butenyl)-8-chloroimidazo[4,5,1-jk][1,4]benzodiazepine-2(1H)-thione
Synonyms: R-86183;8-Cltibo;Nsc636661;Aids002738;Aids-002738;8-Chloro-TIBO;4,5,6,7-Tetrahydro-5α-methyl-6-(3-methyl-2-butenyl)-8-chloroimidazo[4,5,1-jk][1,4]benzodiazepine-2(1H)-thione;(5S)-6-(3-Methyl-2-butenyl)-4,5,6,7-tetrahydro-5α-methyl-8-chloroimidazo[4,5,1-jk][1,4]benzodiazepine-2(1H)-thione;(+)-(S)-4,5,6,7-Tetrahydro-8-chloro-5-methyl-6-(3-methyl-2-butenyl)imidazo[4,5,1-jk][1,4]benzodiazepine-2-(1H)-thione
CBNumber: CB92344439
Molecular Formula: C16H20ClN3S
Formula Weight: 321.874
MOL File: 137332-54-8.mol

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: INB0003881
Product name: TIVIRAPINE
Purity: 95.00%
Packaging: 5MG
Price: $496.88
Updated: 2021/12/16

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4,5,6,7-Tetrahydro-5α-methyl-6-(3-methyl-2-butenyl)-8-chloroimidazo[4,5,1-jk][1,4]benzodiazepine-2(1H)-thione Chemical Properties,Usage,Production

Uses

Tivirapine (R86183) is a nonnucleoside HIV-1 RT inhibitor against HIV-1-induced cytopathic effects with an EC50 value of 4 nM. Tivirapine inhibits the Yl8lC mutant of HIV-1 RT[1].

References

[1] Ding J, et al. Structure of HIV-1 RT/TIBO R 86183 complex reveals similarity in the binding of diverse nonnucleoside inhibitors. Nat Struct Biol. 1995 May;2(5):407-15. DOI:10.1038/nsb0595-407
[2] Zhou Z, et al. Relative free energy of binding and binding mode calculations of HIV-1 RT inhibitors based on dock-MM-PB/GS. Proteins. 2004 Nov 15;57(3):493-503. DOI:10.1002/prot.20223

4,5,6,7-Tetrahydro-5α-methyl-6-(3-methyl-2-butenyl)-8-chloroimidazo[4,5,1-jk][1,4]benzodiazepine-2(1H)-thione Preparation Products And Raw materials

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4,5,6,7-Tetrahydro-5α-methyl-6-(3-methyl-2-butenyl)-8-chloroimidazo[4,5,1-jk][1,4]benzodiazepine-2(1H)-thione Suppliers

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137332-54-8, 4,5,6,7-Tetrahydro-5α-methyl-6-(3-methyl-2-butenyl)-8-chloroimidazo[4,5,1-jk][1,4]benzodiazepine-2(1H)-thioneRelated Search:

4,5,6,7-Tetrahydro-5α-methyl-6-(3-methyl-2-butenyl)-8-chloroimidazo[4,5,1-jk][1,4]benzodiazepine-2(1H)-thione 6-CHLORO-2,3-DIAMINOTOLUENE benzimidazoline-2-thione 2H-Benzimidazole-2-thione,1,3-dihydro-4-methyl-(9CI) 1-(3-CHLORO-2-METHYLPHENYL)-2-THIOUREA 5-Chloro-2-mercaptobenzimidazole

(5S)-6-(3-Methyl-2-butenyl)-4,5,6,7-tetrahydro-5α-methyl-8-chloroimidazo[4,5,1-jk][1,4]benzodiazepine-2(1H)-thione

4,5,6,7-Tetrahydro-5α-methyl-6-(3-methyl-2-butenyl)-8-chloroimidazo[4,5,1-jk][1,4]benzodiazepine-2(1H)-thione

8-Chloro-TIBO

R-86183

(+)-(S)-4,5,6,7-Tetrahydro-8-chloro-5-methyl-6-(3-methyl-2-butenyl)imidazo[4,5,1-jk][1,4]benzodiazepine-2-(1H)-thione

8-Cltibo

Aids002738

Aids-002738

Nsc636661

137332-54-8