6-BROMO-2-METHYL-1,3-BENZOTHIAZOLE
- Product Name
- 6-BROMO-2-METHYL-1,3-BENZOTHIAZOLE
- CAS No.
- 5304-21-2
- Chemical Name
- 6-BROMO-2-METHYL-1,3-BENZOTHIAZOLE
- Synonyms
- 3-BENZOTHIAZOLE;6-BROMO-2-METHYL-1;2-Methyl-6-bromobenzothiazole;6-BROMO-2-METHYLBENZOTHIAZOLE;Benzothiazole, 6-bromo-2-methyl-;6-broMo-2-Methylbenzo[d]thiazole;6-BROMO-2-METHYL-1,3-BENZOTHIAZOLE;2-Methyl-benzothiazole-6-carbaldehyde;6-Bromo-2-methyl-1,3-benzothiazole 98%
- CBNumber
- CB8839262
- Molecular Formula
- C8H6BrNS
- Formula Weight
- 228.11
- MOL File
- 5304-21-2.mol
6-BROMO-2-METHYL-1,3-BENZOTHIAZOLE Property
- Melting point:
- 82-84
- Boiling point:
- 299.1±13.0 °C(Predicted)
- Density
- 1.644±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- form
- solid
- pka
- 1.00±0.10(Predicted)
- color
- Beige
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H319Causes serious eye irritation
- Precautionary statements
-
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B697083
- Product name
- 6-Bromo-2-methyl-1,3-benzothiazole
- Packaging
- 500mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- B697083
- Product name
- 6-Bromo-2-methyl-1,3-benzothiazole
- Packaging
- 1g
- Price
- $110
- Updated
- 2021/12/16
- Product number
- OR12044
- Product name
- 6-Bromo-2-methyl-1,3-benzothiazole
- Purity
- 98%
- Packaging
- 1g
- Price
- $47
- Updated
- 2021/12/16
- Product number
- 072615
- Product name
- 6-Bromo-2-methyl-1,3-benzothiazole
- Purity
- 95+%
- Packaging
- 1g
- Price
- $50
- Updated
- 2021/12/16
- Product number
- 7H70-9-17
- Product name
- 6-Bromo-2-methyl-1,3-benzothiazole
- Purity
- 98%
- Packaging
- 1g
- Price
- $52
- Updated
- 2021/12/16
6-BROMO-2-METHYL-1,3-BENZOTHIAZOLE Chemical Properties,Usage,Production
Chemical Properties
Pale yellow liquid
Synthesis
562080-91-5
5304-21-2
General procedure for the synthesis of 6-bromo-2-methyl-1,3-benzothiazole from N-(4-bromo-2-iodophenyl)acetamide: N-(4-bromo-2-iodophenyl)acetamide (678 mg, 2.00 mmol) was dissolved in N,N-dimethylformamide (4.00 mL), followed by the addition of sodium sulfide nonahydrate (721 mg, 6.00 mmol) and copper iodide (I) (38.0 mg, 0.200 mmol). The reaction mixture was stirred at 80 °C. After the reaction was completed, it was cooled to room temperature, concentrated hydrochloric acid (1.6 mL) was added, and stirring was continued at 80 °C for 12 hours. At the end of the reaction, saturated aqueous sodium bicarbonate solution (20 mL) was added to neutralize. Extraction was performed with ethyl acetate (50 mL x 2). The organic layers were combined, washed with saturated aqueous sodium chloride solution and dried over anhydrous magnesium sulfate. The solvent was removed by distillation under reduced pressure and the residue was purified by silica gel column chromatography to afford 6-bromo-2-methyl-1,3-benzothiazole (134 mg, 29.5% yield) using hexane/ethyl acetate (4:1, v/v) as eluent.
References
[1] Angewandte Chemie, International Edition, 2009, vol. 48, # 23, p. 4222 - 4225
[2] Journal of Medicinal Chemistry, 2015, vol. 58, # 18, p. 7241 - 7257
[3] Patent: JP2016/79108, 2016, A. Location in patent: Paragraph 0055
[4] Patent: JP2015/89879, 2015, A. Location in patent: Paragraph 0016; 0037; 0038; 0040
6-BROMO-2-METHYL-1,3-BENZOTHIAZOLE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 6-BROMO-2-METHYL-1,3-BENZOTHIAZOLE manufacturers
- Product
- 6-Bromo-2-methylbenzo[d]thiazole 5304-21-2
- Price
- US $10.00-50.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2025-06-18
- Product
- 6-Bromo-2-Methyl-1,3-Benzothiazole 5304-21-2
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99.1%
- Supply Ability
- 100 tons
- Release date
- 2022-01-14