3-HYDROXY-4,5,6,6A-TETRAHYDRO-3AH-PYRROLO[3,4-D]ISOXAZOLE-6-CARBOXYLIC ACID

Product Name: 3-HYDROXY-4,5,6,6A-TETRAHYDRO-3AH-PYRROLO[3,4-D]ISOXAZOLE-6-CARBOXYLIC ACID
CAS No.: 227619-65-0
Chemical Name: 3-HYDROXY-4,5,6,6A-TETRAHYDRO-3AH-PYRROLO[3,4-D]ISOXAZOLE-6-CARBOXYLIC ACID
Synonyms: HIP-B;(±)HIPB,(±) HIP B;3-HYDROXY-4,5,6,6A-TETRAHYDRO-3AH-PYRROLO[3,4-D]ISOXAZOLE-6-CARBOXYLIC ACID;rel-(3aR,6R,6aR)-Hexahydro-3-oxo-2H-pyrrolo[3,4-d]isoxazole-6-carboxylic acid;2H-Pyrrolo[3,4-d]isoxazole-6-carboxylic acid, hexahydro-3-oxo-, (3aR,6R,6aR)-rel-
CBNumber: CB8839808
Molecular Formula: C6H8N2O4
Formula Weight: 172.14
MOL File: 227619-65-0.mol

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3-HYDROXY-4,5,6,6A-TETRAHYDRO-3AH-PYRROLO[3,4-D]ISOXAZOLE-6-CARBOXYLIC ACID Property

storage temp.: Store at +4°C
form: Powder
Water Solubility: Soluble to 20 mM in water

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ApexBio Technology

Product number: B6983
Product name: (±)-HIP-B
Packaging: 10mg
Price: $322
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0370816
Product name: 3-HYDROXY-4,5,6,6ALPHA-TETRAHYDRO-3AH-PYRROLO[3,4-D]ISOXAZOLE-6-CARBOXYLIC ACID
Purity: 95.00%
Packaging: 5MG
Price: $495.21
Updated: 2021/12/16

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3-HYDROXY-4,5,6,6A-TETRAHYDRO-3AH-PYRROLO[3,4-D]ISOXAZOLE-6-CARBOXYLIC ACID Chemical Properties,Usage,Production

Uses

HIP-B is a potent, non-competitive excitatory amino acid transporter (EAAT) blocker. It can also be used as AMPA-Kainate receptor agonists.

Biological Activity

Potent, non-competitive excitatory amino acid transporter (EAAT) blocker. Preferentially inhibits glutamate-induced [ 3 H]D-aspartate release (IC 50 = 1.2 μ M) rather than [ 3 H]L-glutamate uptake (IC 50 = 16.9 μ M). Moderately selective; displays no affinity for NMDA and metabotropic glutamate receptors, and low affinity for AMPA and kainate receptors (IC 50 values are 35 and 45 μ M respectively).

3-HYDROXY-4,5,6,6A-TETRAHYDRO-3AH-PYRROLO[3,4-D]ISOXAZOLE-6-CARBOXYLIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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3-HYDROXY-4,5,6,6A-TETRAHYDRO-3AH-PYRROLO[3,4-D]ISOXAZOLE-6-CARBOXYLIC ACID Suppliers

China 6 Germany 3 United Kingdom 1 United States 5 Global 15

Service Chemical Inc.

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BIOTREND GmbH

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BIOTREND Chemicals AG

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227619-65-0, 3-HYDROXY-4,5,6,6A-TETRAHYDRO-3AH-PYRROLO[3,4-D]ISOXAZOLE-6-CARBOXYLIC ACIDRelated Search:

CIS-3-HYDROXY-DL-PROLINE 3-HYDROXY-4,5,6,6A-TETRAHYDRO-3AH-PYRROLO[3,4-D]ISOXAZOLE-6-CARBOXYLIC ACID

3-HYDROXY-4,5,6,6A-TETRAHYDRO-3AH-PYRROLO[3,4-D]ISOXAZOLE-6-CARBOXYLIC ACID

HIP-B

2H-Pyrrolo[3,4-d]isoxazole-6-carboxylic acid, hexahydro-3-oxo-, (3aR,6R,6aR)-rel-

rel-(3aR,6R,6aR)-Hexahydro-3-oxo-2H-pyrrolo[3,4-d]isoxazole-6-carboxylic acid

(±)HIPB,(±) HIP B

227619-65-0

Glutamate receptor