PAGOCLONE

Product Name: PAGOCLONE
CAS No.: 133737-32-3
Chemical Name: PAGOCLONE
Synonyms: Ip 456;CI-1043;RP 59037;AGOCLONE;Rp 62955;(+)-Pagoclone;Pagoclone ((+)-RP-59037;(+)-RP-59037; IP-456; RP-62955; CI-1043;2-(7-Chloro-1,8-naphthyridin-2-yl)-3-(5-Methyl-2-oxohexyl)isoindolin-1-one;2-(7-Chloro-1,8-naphthyridin-2-yl)-3-(5-methyl-2-oxohexyl)-1-isoindolinone
CBNumber: CB8839954
Molecular Formula: C23H22ClN3O2
Formula Weight: 407.89
MOL File: 133737-32-3.mol

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PAGOCLONE Property

Boiling point:: 582.1±50.0 °C(Predicted)
Density: 1.273±0.06 g/cm3(Predicted)
pka: 1.62±0.30(Predicted)
form: Solid
color: White to off-white
InChI: InChI=1S/C23H22ClN3O2/c1-14(2)7-10-16(28)13-19-17-5-3-4-6-18(17)23(29)27(19)21-12-9-15-8-11-20(24)25-22(15)26-21/h3-6,8-9,11-12,14,19H,7,10,13H2,1-2H3
InChIKey: HIUPRQPBWVEQJJ-UHFFFAOYSA-N
SMILES: C1(=O)C2=C(C=CC=C2)C(CC(=O)CCC(C)C)N1C1=CC=C2C(=N1)N=C(Cl)C=C2

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Biosynth Carbosynth

Product number: BP177437
Product name: Pagoclone NEW
Packaging: 25mg
Price: $198.75
Updated: 2021/12/16

Biosynth Carbosynth

Product number: BP177437
Product name: Pagoclone NEW
Packaging: 50mg
Price: $265
Updated: 2021/12/16

Biosynth Carbosynth

Product number: BP177437
Product name: Pagoclone NEW
Packaging: 100mg
Price: $360
Updated: 2021/12/16

Biosynth Carbosynth

Product number: BP177437
Product name: Pagoclone NEW
Packaging: 250mg
Price: $475
Updated: 2021/12/16

Biosynth Carbosynth

Product number: BP177437
Product name: Pagoclone NEW
Packaging: 500mg
Price: $650
Updated: 2021/12/16

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PAGOCLONE Chemical Properties,Usage,Production

Description

Pagoclone is a drug that belongs to the class of cyclopyrrolones. It binds to the benzodiazepine binding site on GABAA receptors and acts as a negative allosteric modulator, thereby enhancing the inhibitory effects of GABA and reducing neuronal excitability.

Uses

Anti-anxiety agent.

Application

Pagoclone has been shown to have anti-inflammatory properties in an animal model of inflammatory bowel disease and may be useful for the treatment of this condition.

brand name

Bextra (Interneuron).

in vivo

Pagoclone (3 mg/kg, p.o.) has significant anxiolytic-like activity, but at all three doses tested (0.3, 1 and 3 mg/kg p.o.) it produces a significant reduction in the total distance travelled. Pagoclone (3 mg/kg, p.o.) produces a dose-dependent increase in time spent on the open arms compared to control. Pagoclone (1, 3 or 10 mg/kg) lowers the cumulative chain-pulling response in the response sensitivity test. Plasma pagoclone concentrations are dose-dependent but not linear, with plasma concentrations of pagoclone being 0.4±0.1, 1.1±0.2 and 2.2±0.2 ng/mL, respectively. Pagoclone (0.3, 1 or 3 mg/kg) reduces locomotor activity in rats in a dose dependent manner^[1].

PAGOCLONE Preparation Products And Raw materials

Raw materials

Preparation Products

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PAGOCLONE Suppliers

China 43 India 1 United Kingdom 2 United States 9 Global 55

Shanghai T&W Pharmaceutical Co., Ltd.

Tel: +86 21 61551611
Fax: +86 21 50676805
Country: China
ProdList: 9891
Advantage: 58

Finetech Industry Limited

Tel: 027-87465837 19945049750
Fax: 027-8777-2287
Email: sales@finetechnology-ind.com
Country: China
ProdList: 9637
Advantage: 58

Chizhou Kailong Import and Export Trade Co., Ltd.

Tel
Fax: -
Email: xg01_gj@163.com
Country: China
ProdList: 9484
Advantage: 50

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9803
Advantage: 58

parabiochem

Tel: 025-83453382-8005
Fax: 025-83453382
Email: sale@parabiochem.com
Country: China
ProdList: 9595
Advantage: 55

Aishilun biotechnology (Shanghai) co., LTD

Tel: 021-50676523 18019098996
Email: info@acelybio.com
Country: China
ProdList: 3960
Advantage: 58

Finetech Industry Limited

Tel: +86-27-8746-5837 +8619945049750
Fax: 86 27 87772287
Email: info@finetechnology-ind.com
Country: China
ProdList: 9629
Advantage: 58

Zhejiang J&C Biological Technology Co.,Limited

Tel: +1-2135480471
Email: sales@sarms4muscle.com
Country: China
ProdList: 10473
Advantage: 58

Xi'an MC Biotech, Co., Ltd.

Tel: 029-89275612 +8618991951683
Fax: 8618991951683
Email: mcbio_sales@163.com
Country: China
ProdList: 2251
Advantage: 58

Shanghai Biolang Biotechnology Co., Ltd.

Tel: +86-15970428662 +86-13397199602
Fax: +8613397199602
Email: Niky@biolang.cn
Country: China
ProdList: 515
Advantage: 58

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View Lastest Price from PAGOCLONE manufacturers

RongNa Biotechnology Co.,Ltd

Product: Pagoclone 133737-32-3
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 100kg
Release date: 2024-03-26

Shandong Hanjiang Chemical Co., Ltd

Product: PAGOCLONE 133737-32-3
Price: US $0.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 10T
Release date: 2024-01-25

airuikechemical co., ltd.

Product: PAGOCLONE 133737-32-3
Price: US $0.00-0.00/Kg
Min. Order: 1Kg
Purity: 99.9%
Supply Ability: 20 tons
Release date: 2024-04-07

133737-32-3, PAGOCLONERelated Search:

Venlafaxine Risperidone IMIPRAMINE Olanzapine PAGOCLONE 2-CHLORO-1,8-NAPHTHYRIDINE

2-(7-Chloro-1,8-naphthyridin-2-yl)-3-(5-methyl-2-oxohexyl)-1-isoindolinone

RP 59037

Ip 456

Rp 62955

2-(7-Chloro-1,8-naphthyridin-2-yl)-3-(5-Methyl-2-oxohexyl)isoindolin-1-one

(+)-RP-59037; IP-456; RP-62955; CI-1043

CI-1043

AGOCLONE

inhibit,GABA Receptor,γ-Aminobutyric acid Receptor,Gamma-aminobutyric acid Receptor,IP 456,RP 62955,RP62955,Pagoclone,Inhibitor

(+)-Pagoclone

2-(7-chloro-1,8-naphthyridin-2-yl)-3-(5-methyl-2-oxohexyl)-3H-isoindol-1-one

Pagoclone ((+)-RP-59037

133737-32-3

C23H22ClN3O2