Nicaraven
- Product Name
- Nicaraven
- CAS No.
- 79455-30-4
- Chemical Name
- Nicaraven
- Synonyms
- AVS;NICARAVEN;Nicaraven, >98%;Nicaraven, 79455-30-4;Nicaraven, 10 mM in DMSO;1,2-bis(nicotinamido)propane;n,n'-propylenedinicotinamide;N,N'-Propylenebisnicotinamide;N,N'-Propylenebis(nicotinamide);N,N'-(Propane-1,2-diyl)dinicotinaMide
- CBNumber
- CB8841557
- Molecular Formula
- C15H16N4O2
- Formula Weight
- 284.31
- MOL File
- 79455-30-4.mol
Nicaraven Property
- Melting point:
- 156-157°
- Boiling point:
- 635.9±40.0 °C(Predicted)
- Density
- 1.213±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- solubility
- DMF: 5 mg/ml; DMSO: 10 mg/ml; Ethanol: 2 mg/ml; PBS (pH 7.2): 2 mg/ml
- form
- A crystalline solid
- pka
- 12.93±0.46(Predicted)
- color
- White to off-white
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P330Rinse mouth.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 23482
- Product name
- Nicaraven
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 23482
- Product name
- Nicaraven
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $57
- Updated
- 2024/03/01
- Product number
- 23482
- Product name
- Nicaraven
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $116
- Updated
- 2024/03/01
- Product number
- FN65102
- Product name
- Nicaraven
- Packaging
- 10mg
- Price
- $62.5
- Updated
- 2021/12/16
- Product number
- FN65102
- Product name
- Nicaraven
- Packaging
- 50mg
- Price
- $81
- Updated
- 2021/12/16
Nicaraven Chemical Properties,Usage,Production
Description
Nicaraven is an antioxidant that exhibits hydroxyl radical scavenging activity in vitro. Nicaraven (1-3 mg/kg per min, i.v.) reduces occurrence of chronic cerebral vasospasms in a dose-dependent manner in a canine model of subarachnoid hemorrhage. In a canine model of warm hepatic ischemia and reperfusion injury, nicaraven (2 mg/kg per min, i.v.) reduces liver enzyme release and inhibits lipid peroxidation and neutrophil infiltration in the liver. Nicaraven (100 mg/kg per day, i.p.) also decreases plasma levels of the inflammatory cytokines Il-6 and Tnf-α and the urinary levels of 8-oxo-2''-deoxyguanosine, a marker of DNA oxidation, in a mouse model of radiation-induced injury.
Uses
Nicaraven is a novel chemically synthesized hydroxyl radical-specific scavenger.
in vivo
Nicaraven inhibits lipid peroxidation in the liver, improves hepatic and systemic hemodynamics and energy metabolism, and suppresses liver enzyme release, endothelin-1 elevation in hepatic venous blood, histologic damage, and neutrophil infiltration into the liver[1]. Nicaraven increases the number of c-kit(+) stem/progenitor cells in bone marrow and peripheral blood, with a recovery rate around 60-90% of age-matched non-irradiated healthy mice. The potency of colony forming from hematopoietic stem/progenitor cells as indicator of function is completely protected with nicaraven treatment[2]. Administration of nicaraven significantly increases the number, improves the colony-forming capacity, and decreases the DNA damage of hematopoietic stem/progenitor cells. The urinary levels of 8-oxo-2′-deoxyguanosine, a marker of DNA oxidation, are significantly lower in mice that are given nicaraven compared with those that receive a placebo. The administration of nicaraven significantly decreases the levels of the inflammatory cytokines IL-6 and TNF-α in the plasma of mice[3].
References
[1] Komiya T, et al. A novel free radical scavenger, nicaraven, inhibits human platelet aggregation in vitro. Clin Neuropharmacol. 1999 Jan-Feb;22(1):11-4. DOI:10.1097/00002826-199901000-00003
[2] Yokota R, et al. A novel hydroxyl radical scavenger, nicaraven, protects the liver from warm ischemia and reperfusion injury. Surgery. 2000 Jun;127(6):661-9. DOI:10.1067/msy.2000.105864
[3] Ali H, et al. The potential benefits of nicaraven to protect against radiation-induced injury in hematopoietic stem/progenitor cells with relative low dose exposures. DOI:10.1016/j.bbrc.2014.08.112
[4] Nicaraven attenuates radiation-induced injury in hematopoietic stem/progenitor cells in mice. PLoS One. 2013;8(3):e60023. DOI:10.1371/journal.pone.0060023
Nicaraven Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Nicaraven manufacturers
- Product
- Nicaraven 79455-30-4
- Price
- US $1.00/ASSAYS
- Min. Order
- 1ASSAYS
- Purity
- 95%~99%
- Supply Ability
- per week:100kg
- Release date
- 2019-09-05