ChemicalBook > CAS DataBase List > 4-[3-(5-BROMO-2-PROPOXYPHENYL)-5-(4-CHLOROPHENYL)-1H-PYRROL-2-YL]PYRIDINE
4-[3-(5-BROMO-2-PROPOXYPHENYL)-5-(4-CHLOROPHENYL)-1H-PYRROL-2-YL]PYRIDINE
- Product Name
- 4-[3-(5-BROMO-2-PROPOXYPHENYL)-5-(4-CHLOROPHENYL)-1H-PYRROL-2-YL]PYRIDINE
- CAS No.
- 191034-25-0
- Chemical Name
- 4-[3-(5-BROMO-2-PROPOXYPHENYL)-5-(4-CHLOROPHENYL)-1H-PYRROL-2-YL]PYRIDINE
- Synonyms
- 049;L-168;L-168,049;4-[3-(5-BROMO-2-PROPOXYPHENYL)-5-(4-CHLOROPHENYL)-1H-PYRROL-2-YL]PYRIDINE;Pyridine, 4-[3-(5-bromo-2-propoxyphenyl)-5-(4-chlorophenyl)-1H-pyrrol-2-yl]-
- CBNumber
- CB8842589
- Molecular Formula
- C24H20BrClN2O
- Formula Weight
- 467.79
- MOL File
- 191034-25-0.mol
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4-[3-(5-BROMO-2-PROPOXYPHENYL)-5-(4-CHLOROPHENYL)-1H-PYRROL-2-YL]PYRIDINE Property
- Boiling point:
- 542.3±50.0 °C(Predicted)
- Density
- 1.367±0.06 g/cm3(Predicted)
- storage temp.
- Store at RT
- solubility
- Soluble to 100 mM in DMSO and to 100 mM in ethanol
- form
- Light beige solid
- pka
- 13.99±0.50(Predicted)
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- 346003
- Product name
- Glucagon Receptor Antagonist II - CAS 191034-25-0 - Calbiochem<br />The Glucagon Receptor Antagonist II, also referenced under CAS 191034-25-0, controls the biological activity of Glucagon Receptor.
- Packaging
- 5mg
- Price
- $216
- Updated
- 2024/03/01
Tocris
- Product number
- 2311
- Product name
- L-168,049
- Purity
- ≥99%(HPLC)
- Packaging
- 10
- Price
- $184
- Updated
- 2021/12/16
Tocris
- Product number
- 2311
- Product name
- L-168,049
- Purity
- ≥99%(HPLC)
- Packaging
- 50
- Price
- $774
- Updated
- 2021/12/16
Usbiological
- Product number
- 255628
- Product name
- L-168,049
- Packaging
- 10mg
- Price
- $423
- Updated
- 2021/12/16
TRC
- Product number
- L210840
- Product name
- L-168,049
- Packaging
- 2.5mg
- Price
- $195
- Updated
- 2021/12/16
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4-[3-(5-BROMO-2-PROPOXYPHENYL)-5-(4-CHLOROPHENYL)-1H-PYRROL-2-YL]PYRIDINE Chemical Properties,Usage,Production
Uses
L- is a potent (Kb = 25 nM), selective antagonist of glucagon.
Definition
ChEBI: 4-[3-(5-bromo-2-propoxyphenyl)-5-(4-chlorophenyl)-1H-pyrrol-2-yl]pyridine is a member of pyrroles.
Biological Activity
Very potent and selective, non-competitive antagonist of the human glucagon receptor (hGR). Binds with high affinity to human GR (IC 50 = 3.7 nM), and moderate affinity to murine and canine GRs (IC 50 values are 63 and 60 nM respectively). In contrast, displays poor affinity for rat, guinea pig, and rabbit glucagon receptors (IC 50 > 1 μ M). In functional studies, inhibits glucagon-stimulated cAMP synthesis in CHO cells expressing hGR (IC 50 = 41 nM), and in murine liver membranes. Orally active in vivo .
storage
Store at RT
4-[3-(5-BROMO-2-PROPOXYPHENYL)-5-(4-CHLOROPHENYL)-1H-PYRROL-2-YL]PYRIDINE Preparation Products And Raw materials
Raw materials
Preparation Products
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