ChemicalBook > CAS DataBase List > 2-TRIFLUOROMETHYL-PYRIMIDINE-5-CARBALDEHYDE

2-TRIFLUOROMETHYL-PYRIMIDINE-5-CARBALDEHYDE

Product Name
2-TRIFLUOROMETHYL-PYRIMIDINE-5-CARBALDEHYDE
CAS No.
304693-66-1
Chemical Name
2-TRIFLUOROMETHYL-PYRIMIDINE-5-CARBALDEHYDE
Synonyms
2-Trifluoromethyl-5-formylpyrimidine;2-（trifluromethyl）pyridine-5-carbaldehyde;2-TRIFLUOROMETHYL-PYRIMIDINE-5-CARBALDEHYDE;2-Trifluoromethyl-5-pyrimidinecarboxaldehyde;2-(Trifluoromethyl)pyrimidine-5-carbaldehydec;5-Pyrimidinecarboxaldehyde,2-(trifluoromethyl)-;2-TRIFLUOROMETHYL-PYRIMIDINE-5-CARBALDEHYDE ISO 9001：2015 REACH
CBNumber
CB8844523
Molecular Formula
C6H3F3N2O
Formula Weight
176.1
MOL File
304693-66-1.mol
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2-TRIFLUOROMETHYL-PYRIMIDINE-5-CARBALDEHYDE Property

Boiling point:
153℃
Density 
1.454
Flash point:
47℃
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
pka
-3.47±0.22(Predicted)
Appearance
White to light yellow Solid
InChI
InChI=1S/C6H3F3N2O/c7-6(8,9)5-10-1-4(3-12)2-11-5/h1-3H
InChIKey
GAUDQBASERVUGM-UHFFFAOYSA-N
SMILES
C1(C(F)(F)F)=NC=C(C=O)C=N1
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
T899055
Product name
2-(Trifluoromethyl)pyrimidine-5-carbaldehyde
Packaging
100mg
Price
$65
Updated
2021/12/16
TRC
Product number
T899055
Product name
2-(Trifluoromethyl)pyrimidine-5-carbaldehyde
Packaging
500mg
Price
$220
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
NUC0001597
Product name
2-(TRIFLUOROMETHYL)PYRIMIDINE-5-CARBALDEHYDE
Purity
95.00%
Packaging
250MG
Price
$347.55
Updated
2021/12/16
AK Scientific
Product number
W5289
Product name
2-(Trifluoromethyl)pyrimidine-5-carbaldehyde
Packaging
5g
Price
$611
Updated
2021/12/16
Matrix Scientific
Product number
090160
Product name
2-(Trifluoromethyl)pyrimidine-5-carbaldehyde
Purity
95+%
Packaging
1g
Price
$425
Updated
2021/12/16
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2-TRIFLUOROMETHYL-PYRIMIDINE-5-CARBALDEHYDE Chemical Properties,Usage,Production

Synthesis

304693-64-9

304693-66-1

Step B: Synthesis of 2-(trifluoromethyl)pyrimidine-5-carbaldehyde To a solution of ethyl 2-(trifluoromethyl)pyrimidine-5-carboxylate (25.5 g, 116.0 mmol) in dichloromethane (580 mL) was slowly added diisobutylaluminum hydride (1.0 M, 130.0 mL, 130.0 mmol) at -78 °C. The reaction mixture was kept stirred at -78 °C for 2 hours. Subsequently, the reaction was quenched by slow addition of hydrochloric acid (2.0 M). The mixture was gradually warmed up to ambient temperature. The mixture was extracted with ether (3 times). The organic phases were combined, dried over anhydrous sodium sulfate, filtered and concentrated to give the target product 2-(trifluoromethyl)pyrimidine-5-carbaldehyde (28.2 g).

References

[1] Patent: US2004/167142, 2004, A1. Location in patent: Page/Page column 23;24
[2] Patent: TW2016/5858, 2016, A. Location in patent: Page/Page column 133; 134
[3] Patent: US2014/107335, 2014, A1. Location in patent: Paragraph 0091; 0092
[4] Bioorganic and Medicinal Chemistry Letters, 2002, vol. 12, # 1, p. 51 - 55
[5] Patent: WO2010/111058, 2010, A1. Location in patent: Page/Page column 69

2-TRIFLUOROMETHYL-PYRIMIDINE-5-CARBALDEHYDE Preparation Products And Raw materials

Raw materials

Sodium hydride Silica gel Ethanol Manganese dioxide Tetrahydrofuran Diethyl ether Ethyl acetate Lithium Aluminum Hydride Dichloromethane Ethyl 3,3-Diethoxypropionate Trifluoroacetamidine

Preparation Products

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2-TRIFLUOROMETHYL-PYRIMIDINE-5-CARBALDEHYDE Suppliers

China 80 India 2 Ukraine 1 United States 8 Global 91
Weifang Yuda Pharmaceutical Technology Co., Ltd.
Tel
17663603912
Fax
+86-536- 8637276
Email
2710256076@qq.com
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China
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196
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56
PharmaBlock Sciences (Nanjing),Inc.
Tel
025-86918202 4000255188
Fax
86-025-86918232
Email
sales@pharmablock.com
Country
China
ProdList
5000
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55
Jia Xing Isenchem Co.,Ltd
Tel
0573-85285100 18627885956
Fax
0573-85285100
Email
isenchem@163.com
Country
China
ProdList
9310
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66
Pure Chemistry Scientific Inc.
Tel
001-857-928-2050 or 1-888-588-9418
Fax
001-617-206-9595
Email
sales@chemreagents.com
Country
United States
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10186
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Shanghai Hanhong Scientific Co.,Ltd.
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021-54306202 13764082696
Email
info@hanhongsci.com
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China
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42934
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64
Nanjing Vital Chemical Co., Ltd.
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Please Send Email 18652950785
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025-87193546
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chemweiao@163.com
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China
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4378
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65
Shanghai Topbiochem Technology Co., Ltd
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021-58170097
Email
info@topbiochem.com
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China
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9510
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Shanghai T&W Pharmaceutical Co., Ltd.
Tel
+86 21 61551611
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+86 21 50676805
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China
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9891
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Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.
Tel
025-66113011 17798518460
Fax
(1)02557626880
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cfzhang@aikonchem.com
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China
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19913
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SynAsst Chemical.
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021-60343070
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021-35122006
Country
China
ProdList
12740
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View Lastest Price from 2-TRIFLUOROMETHYL-PYRIMIDINE-5-CARBALDEHYDE manufacturers

Dideu Industries Group Limited
Product
2-TRIFLUOROMETHYL-PYRIMIDINE-5-CARBALDEHYDE 304693-66-1
Price
US $1.10/g
Min. Order
1g
Purity
99.00%
Supply Ability
100 Tons Min
Release date
2021-12-07
Career Henan Chemical Co
Product
2-TRIFLUOROMETHYL-PYRIMIDINE-5-CARBALDEHYDE 304693-66-1
Price
US $2.00/KG
Min. Order
1g
Purity
98%min
Supply Ability
ask
Release date
2020-01-08

304693-66-1, 2-TRIFLUOROMETHYL-PYRIMIDINE-5-CARBALDEHYDERelated Search:

ETHYL 4-HYDROXY-2-(TRIFLUOROMETHYL)PYRIMIDINE-5-CARBOXYLATE Ethyl 4-chloro-2-(trifluoromethyl)pyrimidine-5-carboxylate ETHYL-2-TRIFLUOROMETHYL-4-METHYL-5-PYRIMIDINE CARBOXYLATE ETHYL 4-AMINO-2-(TRIFLUOROMETHYL)PYRIMIDINE-5-CARBOXYLATE ETHYL-2-TRIFLUOROMETHYL-4-CYCLOPROPYL-5-PYRIMIDINE CARBOXYLATE ETHYL-2-TRIFLUOROMETHYL-4-TRIFLUOROMETHYL-5-PYRIMIDINE CARBOXYLATE ETHYL-2-TRIFLUOROMETHYL-4-PHENYL-5-PYRIMIDINE CARBOXYLATE ETHYL-2-TRIFLUOROMETHYL-4-(2-METHOXYPHENYL)-5-PYRIMIDINE CARBOXYLATE ETHYL-2-TRIFLUOROMETHYL-4-PROPYL-5-PYRIMIDINE CARBOXYLATE ETHYL-2-TRIFLUOROMETHYL-4-(2-BROMOPHENYL)-5-PYRIMIDINE CARBOXYLATE ETHYL-2-TRIFLUOROMETHYL-4-(2-METHYLPHENYL)-5-PYRIMIDINE CARBOXYLATE ETHYL-2-TRIFLUOROMETHYL-4-ISOPROPYL-5-PYRIMIDINE CARBOXYLATE ETHYL-2-TRIFLUOROMETHYL-4-ETHYL-5-PYRIMIDINE CARBOXYLATE ETHYL-2-TRIFLUOROMETHYL-4-(2-IODOPHENYL)-5-PYRIMIDINE CARBOXYLATE SODIUM 5-(ETHOXYCARBONYL)-2-(TRIFLUOROMETHYL)PYRIMIDIN-4-OLATE ETHYL 4-(2-[(2,6-DICHLORO-4-PYRIDYL)CARBONYL]HYDRAZINO)-2-(TRIFLUOROMETHYL)PYRIMIDINE-5-CARBOXYLATE ETHYL 4-HYDRAZINO-2-(TRIFLUOROMETHYL)PYRIMIDINE-5-CARBOXYLATE ETHYL-2-TRIFLUOROMETHYL-4-(2-CHLOROPHENYL)-5-PYRIMIDINE CARBOXYLATE

  • 2-TRIFLUOROMETHYL-PYRIMIDINE-5-CARBALDEHYDE
  • 2-(Trifluoromethyl)pyrimidine-5-carbaldehydec
  • 2-Trifluoromethyl-5-formylpyrimidine
  • 2-Trifluoromethyl-5-pyrimidinecarboxaldehyde
  • 2-（trifluromethyl）pyridine-5-carbaldehyde
  • 5-Pyrimidinecarboxaldehyde,2-(trifluoromethyl)-
  • 2-TRIFLUOROMETHYL-PYRIMIDINE-5-CARBALDEHYDE ISO 9001：2015 REACH
  • 304693-66-1
  • C6H3F3N2O
  • Fluorine series