ChemicalBook > CAS DataBase List > LY 344864

LY 344864

Product Name: LY 344864
CAS No.: 186544-26-3
Chemical Name: LY 344864
Synonyms: CS-660;Y344864;LY 344864;LY344864 HCL;LY344864;LY-344864;LY 344864 hydrochloride;LY 344864 hydrochloride, 5-HT1F agonist;(R)-N-[3-(Dimethylamino)-2,3,4,9-tetrahydro-1H-carbazol-6-yl]-4-fluorobenzamide;Benzamide, N-[(3R)-3-(dimethylamino)-2,3,4,9-tetrahydro-1H-carbazol-6-yl]-4-fluoro-;(R)-N-(3-(Dimethylamino)-2,3,4,9-tetrahydro-1H-carbazol-6-yl)-4-fluorobenzamide hydrochloride
CBNumber: CB8847478
Molecular Formula: C21H22FN3O
Formula Weight: 351.42
MOL File: 186544-26-3.mol

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LY 344864 Property

Boiling point:: 471.9±45.0 °C(Predicted)
Density: 1.28±0.1 g/cm3(Predicted)
storage temp.: Store at +4°C
solubility: DMSO : ≥ 350 mg/mL (995.96 mM)
pka: 14.12±0.40(Predicted)
form: Powder
color: White to off-white
Water Solubility: water: 10mM
DMSO: 100mM

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Tocris

Product number: 2451
Product name: LY344864 hydrochloride
Purity: ≥99%(HPLC)
Packaging: 10
Price: $214
Updated: 2021/12/16

Tocris

Product number: 2451
Product name: LY344864 hydrochloride
Purity: ≥99%(HPLC)
Packaging: 50
Price: $884
Updated: 2021/12/16

ChemScene

Product number: CS-1350
Product name: LY344864
Purity: 99.16%
Packaging: 5mg
Price: $84
Updated: 2021/12/16

ChemScene

Product number: CS-1350
Product name: LY344864
Purity: 99.16%
Packaging: 10mg
Price: $110
Updated: 2021/12/16

ApexBio Technology

Product number: A3569
Product name: LY344864
Packaging: 5mg
Price: $134
Updated: 2021/12/16

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LY 344864 Chemical Properties,Usage,Production

Uses

LY-344864 Hydrochloride is used as a selective 5-HTIF receptor agonist.

Biological Activity

Potent, selective 5-HT 1F receptor agonist (EC 50 = 3 nM). Displays > 80-fold selectivity over other 5-HT receptors (K i values are 0.006, 0.53, 0.55, 0.56, 1.42, 1.70, 3.50, 3.94 and 4.85 μ M for 5-HT 1F , 5-HT 1A , 5-HT 1B , 5-HT 1D , 5-HT 1E , 5-HT 2B , 5-HT 2C , 5-HT 2A and 5-HT 7 receptors respectively). Inhibits neurogenic dural inflammation in vivo following i.v. and oral administration.

in vivo

LY 344864 (0-10 ng/kg; p.o. or i.v.; once) inhibits neurogenic dural inflammation in rat migraine pain model^[1].
LY 344864 (1 mg/kg; i.v.; once) can cross the blood brain barrier to some extent in rats^[1].
LY 344864 (2 mg/kg; i.p.; daily for 14 days) attenuates dopaminergic neuron loss and improved behavioral endpoints in a Parkinson’s disease mouse model^[2].

Animal Model:	Male Wistar rats, migraine pain model^[1]
Dosage:	1-10 ng/kg (oral), 0.3-2 ng/kg (intravenous)
Administration:	Oral, 75 minutes before trigeminal stimulation or intravenous, 10 minutes before trigeminal stimulation
Result:	When given intravenously 10 minutes before stimulation, inhibited inflammation with an ID₅₀ (median infective dose) of 0.6 ng/kg. When administered orally 75 minutes before trigeminal stimulation, an ID₅₀ of 1.2 ng/kg was obtained.

Animal Model:	Male C57BL/6 mice, Parkinson’s disease model^[2]
Dosage:	2 mg/kg
Administration:	Intraperitoneal injection, daily for 14d beginning 7d post-lesion
Result:	Attenuated TH-ir loss in the striatum and substantia nigra compared to vehicle-treated lesioned animals, also increased locomotor activity in 6-hydroxydopamine lesioned mice, while vehicle treatment had no effect.

IC 50

human 5-HT_1F Receptor: 0.006 μM (Ki); human 5-HT_1A Receptor: 0.530 μM (Ki); human 5-HT_1B Receptor: 0.549 μM (Ki); human 5-HT_1D Receptor: 0.575 μM (Ki); human 5-HT_1E Receptor: 1.415 μM (Ki); human 5-HT_2B Receptor: 1.695 μM (Ki); Human 5-HT_2A Receptor: 3.499 μM (Ki); Human 5-HT_3A Receptor: 3.935 mM (Ki); Human 5-HT₇ Receptor: 4.851 μM (Ki); rat α2-adrenergic receptor: 3.69 μM (Ki); rat α1-adrenergic receptor: 5.06 μM (Ki)

LY 344864 Preparation Products And Raw materials

Raw materials

Preparation Products

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LY 344864 Suppliers

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View Lastest Price from LY 344864 manufacturers

Career Henan Chemical Co

Product: LY 344864 186544-26-3
Price: US $1.00/g
Min. Order: 1g
Purity: 99.99%
Supply Ability: 200kg
Release date: 2019-12-24

186544-26-3, LY 344864Related Search:

(R)-3-Amino-1,2,3,4-tetrahydrocarbazole Ciclindole 3-(2-DIMETHYLAMINO-ETHYL)-1H-INDOL-5-YLAMINE 3-Amino-1,2,3,4-tetrahydrocarbazol LY 344864

LY 344864

LY 344864 hydrochloride

N-[(3R)-3-(Dimethylamino)-2,3,4,9-tetrahydro-1H-carbazol-6-yl]-4-fluorobenzamidehydrochloride

(R)-N-[3-(Dimethylamino)-2,3,4,9-tetrahydro-1H-carbazol-6-yl]-4-fluorobenzamide

(R)-N-(3-(Dimethylamino)-2,3,4,9-tetrahydro-1H-carbazol-6-yl)-4-fluorobenzamide hydrochloride

LY344864 HCL

LY344864;LY-344864

CS-660

Y344864

Benzamide, N-[(3R)-3-(dimethylamino)-2,3,4,9-tetrahydro-1H-carbazol-6-yl]-4-fluoro-

migraines,Adrenergic Receptor,BBB penetration,Serotonin Receptor,inhibit,5-HT Receptor,LY-344864,Beta Receptor,Parkinson’s disease,LY 344864,Inhibitor,5-hydroxytryptamine Receptor,5-HT1F

LY 344864 hydrochloride, 5-HT1F agonist

186544-26-3

C21H22N3OFHCl

Inhibitors