TERT-BUTYL 4-BROMOPYRIDIN-2-YLCARBAMATE

Uses

Product Name: TERT-BUTYL 4-BROMOPYRIDIN-2-YLCARBAMATE
CAS No.: 207799-10-8
Chemical Name: TERT-BUTYL 4-BROMOPYRIDIN-2-YLCARBAMATE
Synonyms: tert-Butyl N-(4-bromo-2-pyridyl)carbamate;2-(Boc-amino)-4-bromopyridine;RESTORE?, each (250 mL/bottle);t-Butyl 4-bromopyridin-2-ylcarbamate;TERT-BUTYL 4-BROMOPYRIDIN-2-YLCARBAMATE;Tert-butyl-4-Bromo Pyrion-2-yl-Carbamate;ert-butylN-(4-bromopyridin-2-yl)carbamate;tert-butyl N-(4-broMopyridin-2-yl)carbaMate;(4-Bromo-pyridin-2-yl)-carbamic acid tert-butyl ester;TERT-BUTYL 4-BROMOPYRIDIN-2-YLCARBAMATE ISO 9001：2015 REACH
CBNumber: CB8847771
Molecular Formula: C10H13BrN2O2
Formula Weight: 273.13
MOL File: 207799-10-8.mol

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TERT-BUTYL 4-BROMOPYRIDIN-2-YLCARBAMATE Property

Boiling point:: 296.7±25.0 °C(Predicted)
Density: 1.453±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,2-8°C
pka: 11.89±0.70(Predicted)
Appearance: White to light brown Solid
InChI: InChI=1S/C10H13BrN2O2/c1-10(2,3)15-9(14)13-8-6-7(11)4-5-12-8/h4-6H,1-3H3,(H,12,13,14)
InChIKey: IRRRVCLDPODLJG-UHFFFAOYSA-N
SMILES: C(OC(C)(C)C)(=O)NC1=NC=CC(Br)=C1

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Safety

HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: B603115
Product name: 2-(Boc-amino)-4-bromopyridine
Packaging: 250mg
Price: $75
Updated: 2021/12/16

Activate Scientific

Product number: AS16415
Product name: 2-(Boc-amino)-4-bromopyridine
Purity: 95%
Packaging: 1g
Price: $71
Updated: 2021/12/16

Apolloscientific

Product number: OR302007
Product name: tert-Butyl-4-bromo(pyridin-2-yl)carbamate
Packaging: 1g
Price: $83
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H56-9-20
Product name: 2-(Boc-amino)-4-bromopyridine
Purity: 95%
Packaging: 1g
Price: $104
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB143018
Product name: tert-Butyl (4-bromopyridin-2-yl)carbamate
Packaging: 1g
Price: $137
Updated: 2021/12/16

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TERT-BUTYL 4-BROMOPYRIDIN-2-YLCARBAMATE Chemical Properties,Usage,Production

Uses

tert-butyl (4-bromopyrimidin-2-yl)carbamate can be used as a pharmaceutical synthesis intermediate.

Synthesis

84249-14-9

24424-99-5

207799-10-8

General procedure for the synthesis of 2-Boc amine-4-bromopyridine from 2-amino-4-bromopyridine and di-tert-butyl dicarbonate: To a solution of 4-bromopyridin-2-amine (519 mg) in anhydrous THF (15 mL) was slowly added bis(trimethylmethylsilyl)amide (1 M solution in hexane, 6 mL) at -5 °C and the reaction mixture was stirred. After maintaining this temperature for 10 minutes, di-tert-butyl dicarbonate (654 mg) was added and the reaction mixture was transferred to room temperature to continue stirring for 1 hour. Upon completion of the reaction, the reaction was quenched by the addition of saturated ammonium chloride solution (20 mL) and the mixture was extracted with EtOAc. The organic layers were combined, washed sequentially with water and brine, dried over anhydrous sodium sulfate, and concentrated under reduced pressure to remove the solvent to afford the target product 2-Boc amine-4-bromopyridine in 96% yield.

References

[1] Patent: US2014/194443, 2014, A1. Location in patent: Paragraph 0541-0542
[2] Patent: WO2014/108337, 2014, A1. Location in patent: Page/Page column 69
[3] Patent: WO2016/124508, 2016, A1. Location in patent: Page/Page column 39
[4] Journal of Medicinal Chemistry, 2017, vol. 60, # 13, p. 5613 - 5637
[5] Patent: CN104744433, 2016, B. Location in patent: Paragraph 0027; 0028

TERT-BUTYL 4-BROMOPYRIDIN-2-YLCARBAMATE Preparation Products And Raw materials

Raw materials

Preparation Products

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TERT-BUTYL 4-BROMOPYRIDIN-2-YLCARBAMATE Suppliers

Canada 1 China 131 Germany 1 India 1 United Kingdom 3 United States 12 Global 149

PharmaBlock Sciences (Nanjing), Inc.

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Accela ChemBio Co.,Ltd.

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Energy Chemical

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Tetranov Biopharm

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Shanghai Ennopharm Co., Ltd.

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Syntechem Co.,Ltd

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View Lastest Price from TERT-BUTYL 4-BROMOPYRIDIN-2-YLCARBAMATE manufacturers

Dideu Industries Group Limited

Product: TERT-BUTYL 4-BROMOPYRIDIN-2-YLCARBAMATE 207799-10-8
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons Min
Release date: 2021-12-01

Career Henan Chemical Co

Product: TERT-BUTYL 4-BROMOPYRIDIN-2-YLCARBAMATE 207799-10-8
Price: US $8.80/KG
Min. Order: 1KG
Purity: 97%-99%
Supply Ability: 100kg
Release date: 2019-07-04

207799-10-8, TERT-BUTYL 4-BROMOPYRIDIN-2-YLCARBAMATERelated Search:

4-(4-BROMO-BENZENESULFONYL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER tert-butyl 4-(2,6-dichloropyridin-4-yl)piperazine-1-carboxylate 7-AMINO-3,4-DIHYDRO-1H-ISOQUINOLINE-2-CARBOXYLIC ACID TERT-BUTYL ESTER TERT-BUTYL 6,7-DIHYDROTHIAZOLO[5,4-C]PYRIDINE-5(4H)-CARBOXYLATE Pyrimidine, 4-bromo- (8CI,9CI) 2-Amino-4-bromopyridine TERT-BUTYL 4-BROMOPYRIDIN-2-YLCARBAMATE

TERT-BUTYL 4-BROMOPYRIDIN-2-YLCARBAMATE

2-(Boc-amino)-4-bromopyridine

tert-butyl N-(4-broMopyridin-2-yl)carbaMate

CarbaMicacid,N-(4-broMo-2-pyridinyl)-,1,1-diMethylethylester

tert-Butyl N-(4-bromo-2-pyridyl)carbamate

t-Butyl 4-bromopyridin-2-ylcarbamate

(4-Bromo-pyridin-2-yl)-carbamic acid tert-butyl ester

ert-butylN-(4-bromopyridin-2-yl)carbamate

TERT-BUTYL 4-BROMOPYRIDIN-2-YLCARBAMATE ISO 9001：2015 REACH

Tert-butyl-4-Bromo Pyrion-2-yl-Carbamate

Hydrolysis Reagent for Carbamate analysis 0.075 M, case of 4 (950 mL /bottle)

RESTORE?, each (250 mL/bottle)

207799-10-8

Halides

Pyridines