7-METHOXY-4(1H)-QUINAZOLINONE

7-METHOXY-4(1H)-QUINAZOLINONE Property

Melting point:

257-258℃

Boiling point:

338.7±44.0 °C(Predicted)

Density 

1.32

storage temp. 

2-8°C

pka

1.51±0.20(Predicted)

Appearance

Brown to black Solid

Safety

HS Code 

2933998090

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

7-METHOXY-4(1H)-QUINAZOLINONE Chemical Properties,Usage,Production

Synthesis

The general procedure for the synthesis of 7-methoxyquinazolin-4(1H)-one from formamidine acetate and 2-amino-4-methoxybenzoic acid was as follows: 1. 2-Amino-4-methoxybenzoic acid (4.85 g, 28.9 mmol) and formamidine acetate (18.49 g, 177.8 mmol) were mixed in 100 mL of 2-methoxyethanol. 2. The reaction mixture was heated to reflux and stirred under these conditions for 12 hours. 3. After completion of the reaction, the mixture was cooled to 25 °C. The reaction was carried out with 0.01 M 4. Dilute the cooled reaction mixture with 0.01 M aqueous ammonia solution (100 mL). 5. Continue stirring at 25 °C for 30 min. 6. Collect the light brown solid product formed by filtration. 7. Wash the solid product with 0.01 M aqueous ammonia solution. 8. 8. The final product 7-methoxyquinazolin-4(1H)-one was obtained by high vacuum drying in a yield of 11.5 g (73% yield). Product characterization data: NMR (δ, ppm): 12.10 (s, br, 1H), 8.05 (m, 2H), 7.10 (m, 2H), 3.90 (s, 3H); m/z 167.

References

[1] Bioorganic and Medicinal Chemistry Letters, 2009, vol. 19, # 17, p. 4963 - 4966
[2] Patent: WO2007/71963, 2007, A2. Location in patent: Page/Page column 52
[3] Patent: CN104447769, 2016, B. Location in patent: Paragraph 0056-0057