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DOTA-(Tyr3)-Octreotate

Product Name
DOTA-(Tyr3)-Octreotate
CAS No.
177943-89-4
Chemical Name
DOTA-(Tyr3)-Octreotate
Synonyms
DOTA-TATE;DOTA-TATE177943-89-4;DOTATATE acetic acid;DOTA-(Tyr3)-Octreotete;7)-disulfide acetate (salt);DOTA-(Tyr3)-Octreotate, 97%+;DOTA-(TYR3)-OCTREOTATE ACETATE;DOTA-(TYR3,THR8)-OCTREOTIDE ACETATE;DOTA-(Tyr?)-Octreotate acetate salt;DOTATATE, DOTA-(Tyr3,Thr8)-Octreotide
CBNumber
CB8848758
Molecular Formula
C67H94N14O21S2
Formula Weight
1495.69
MOL File
177943-89-4.mol
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DOTA-(Tyr3)-Octreotate Property

storage temp. 
Store at -20°C, protect from light, stored under nitrogen
solubility 
PBS (pH 7.2): Slightly Soluble: 0.1-1 mg/ml
form 
Solid
color 
White to off-white
InChIKey
MGIRFLMPSDEBOD-MGZWADLVNA-N
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Safety

HS Code 
29309090
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Biosynth Carbosynth
Product number
FD109795
Product name
DOTA-(Tyr3)-Octreotate acetate salt 4,7,10-Tricarboxymethyl-1,4,7,10-tetraaza-cyclododecan-1-yl-acetyl-D-Phe-Cys-Tyr-D-Trp-Lys-Thr-Cys-Thr-OH acetate salt (Disulfide bond)
Packaging
1mg
Price
$170
Updated
2021/12/16
Biosynth Carbosynth
Product number
FD109795
Product name
DOTA-(Tyr3)-Octreotate acetate salt 4,7,10-Tricarboxymethyl-1,4,7,10-tetraaza-cyclododecan-1-yl-acetyl-D-Phe-Cys-Tyr-D-Trp-Lys-Thr-Cys-Thr-OH acetate salt (Disulfide bond)
Packaging
2mg
Price
$260
Updated
2021/12/16
Biosynth Carbosynth
Product number
FD109795
Product name
DOTA-(Tyr3)-Octreotate acetate salt 4,7,10-Tricarboxymethyl-1,4,7,10-tetraaza-cyclododecan-1-yl-acetyl-D-Phe-Cys-Tyr-D-Trp-Lys-Thr-Cys-Thr-OH acetate salt (Disulfide bond)
Packaging
5mg
Price
$500
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0018721
Product name
DOTA-TATE ACETATE
Purity
95.00%
Packaging
5MG
Price
$502.03
Updated
2021/12/16
Biosynth Carbosynth
Product number
FD109795
Product name
DOTA-(Tyr3)-Octreotate acetate salt 4,7,10-Tricarboxymethyl-1,4,7,10-tetraaza-cyclododecan-1-yl-acetyl-D-Phe-Cys-Tyr-D-Trp-Lys-Thr-Cys-Thr-OH acetate salt (Disulfide bond)
Packaging
10mg
Price
$800
Updated
2021/12/16
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DOTA-(Tyr3)-Octreotate Chemical Properties,Usage,Production

Chemical Properties

Colourless to off-white lyophilised solid

Uses

DOTATATE acetate is a DOTA-conjugated peptide. DOTATATE acetate can be labelled with radionuclides for positron emission tomography (PET) imaging and peptide receptor radionuclide research (PRRT)[1][2][3][4]. DOTATATE (acetate) can be used for the synthesis/research of Radionuclide-Drug Conjugates (RDCs).

in vivo

177Lu-DOTATATE shows excellent antitumor effects in rats[1].

IC 50

RDC Peptide

References

[1] Jong M, et, al. Combination radionuclide therapy using 177Lu- and 90Y-labeled somatostatin analogs. J Nucl Med. 2005 Jan;46 Suppl 1:13S-7S. PMID:15653647
[2] Gains JE, et, al. 68Ga-DOTATATE and 123I-mIBG as imaging biomarkers of disease localisation in metastatic neuroblastoma: implications for molecular radiotherapy. Nucl Med Commun. 2020 Aug 10. DOI:10.1097/MNM.0000000000001265
[3] Breeman WAP, et, al. Optimising conditions for radiolabelling of DOTA-peptides with 90Y, 111In and 177Lu at high specific activities. Eur J Nucl Med Mol Imaging. 2003 Jun;30(6):917-20. DOI:10.1007/s00259-003-1142-0
[4] Reubi JC, et, al. Affinity profiles for human somatostatin receptor subtypes SST1-SST5 of somatostatin radiotracers selected for scintigraphic and radiotherapeutic use. Eur J Nucl Med. 2000 Mar;27(3):273-82. DOI:10.1007/s002590050034
[5] MELPOMENI FANI  Damian W  Guillaume P Nicolas. Somatostatin Receptor Antagonists for Imaging and Therapy.[J]. Journal of Nuclear Medicine, 2017, 58 Suppl 2: 61S-66S. DOI: 10.2967/jnumed.116.186783

DOTA-(Tyr3)-Octreotate Preparation Products And Raw materials

Raw materials

Preparation Products

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DOTA-(Tyr3)-Octreotate Suppliers

China 84 Germany 1 India 1 United Kingdom 1 United States 6 Global 93
ABX Advanced Biochemical Compounds
Tel
--
Fax
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Email
info@abx.de
Country
Germany
ProdList
369
Advantage
68
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View Lastest Price from DOTA-(Tyr3)-Octreotate manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
DOTA-(Tyr3)-Octreotete 177943-89-4
Price
US $0.00/mg
Min. Order
1mg
Purity
≥95% or 98%
Supply Ability
1kg/month
Release date
2021-06-23
ShenZhen H&D Pharmaceutical Technology Co., LTD
Product
DOTA-(Tyr3)-Octreotete 177943-89-4
Price
US $0.00/mg
Min. Order
10mg
Purity
0.98
Supply Ability
5g
Release date
2025-02-14
Dingwang Technology (Wuhan) Co., Ltd.
Product
DOTA-(Tyr3)-Octreotate 177943-89-4
Price
US $0.00/mg
Min. Order
10mg
Purity
99% min
Supply Ability
20 tons
Release date
2023-09-27

177943-89-4, DOTA-(Tyr3)-OctreotateRelated Search:

TYROSINASE DOTA DOTA-D-PHE-CYS-TYR-D-TRP-LYS-THR-CYS-THR-OL (DISULFIDE BRIDGE: 2-7) Octreotide acetate Octreotide DOTA-(Tyr3)-Octreotate TRIS(2-(METHYLAMINO)ETHYL)AMINE 97 N,N,N'-tris(2-aminoethyl)ethylenediamine

  • 4,7,10-TRICARBOXYMETHYL-1,4,7,10-TETRAAZA-CYCLODODECAN-1-YL-ACETYL-D-PHE-CYS-TYR-D-TRP-LYS-THR-CYS-THR-OH, (DISULFIDE BOND) ACETATE
  • DOTA-(TYR3)-OCTREOTATE ACETATE
  • DOTA-(TYR3,THR8)-OCTREOTIDE ACETATE
  • DOTA-(Tyr3)-Octreotete
  • N-[[4,7,10-Tris(carboxymethyl)-1,4,7,10-tetraazacyclododec-1-yl]acetyl]-D-phenylalanyl-L-cysteinyl-L-tyrosyl-D-tryptophyl-L-lysyl-L-threonyl-L-cysteinyl-L-threonine cyclic (2-7)-disulfide acetate (salt)
  • L-Threonine, N-[[4,7,10-tris(carboxymethyl)-1,4,7,10-tetraazacyclododec-1-yl]acetyl]-Dphenylalanyl-L-cysteinyl-L-tyrosyl-D-tryptophyl-L-lysyl-L-threonyl-L-cysteinyl-, cyclic (2)-disulfide, acetate (salt) (9CI)
  • DOTA-(Tyr3)-Octreotate acetate salt 4,7,10-Tricarboxymethyl-1,4,7,10-tetraaza-cyclododecan-1-yl-acetyl-D-Phe-Cys-Tyr-D-Trp-Lys-Thr-Cys-Thr-OH acetate salt (Disulfide bond)
  • S-2-(4-Isothiocyanatobenzyl)-1, 4, 7, 10-tetraaza-1, 4, 7, 10-tetra(2-carbamoylmethyl)cyclododecane
  • 4,7,10-TricarboxyMethyl-1,4,7,10-tetraaza-cyclododecan-1-yl-acetyl-D-Phe-Cys-Tyr-D-Trp-Lys-Thr-Cys-Thr-OH
  • DOTATATE, DOTA-(Tyr3,Thr8)-Octreotide
  • 7)-disulfide acetate (salt)
  • DOTA-TATE
  • DOTA-TATE177943-89-4
  • DOTA-[Tyr3]-Octreotate, DOTA-[Tyr3, Thr8]-Octreotide, DOTA-TATE
  • N-[[4,7,10-tris(carboxymethyl)-1,4,7,10-tetraaza-cyclododec-1-yl]acetyl]-D-phenylalanyl-L-cysteinyl-L-tyrosyl-D-trypto-phyl-L-lysyl-L-threonyl-L-cysteinyl-, cyclic(2-7) disulfide
  • L-Threonine,N-[[4,7,10-tris(carboxymethyl)-1,4,7,10-tetraazacyclododec-1-yl]acetyl]-D-phenylalanyl-L-cysteinyl-L-tyrosyl-D-tryptophyl-L-lysyl-L-threonyl-L-cysteinyl-,cyclic (2→7)-disulfide,acetate (salt)
  • DOTA-(Tyr3)-Octreotate, 97%+
  • DOTA-(Tyr?)-Octreotate acetate salt
  • {DOTA}-{d-Phe}-CY-{d-Trp}-KTCT (Disulfide bridge:Cys2-Cys7)
  • 2,2',2''-(10-(2-(((R)-1-(((4R,7S,10S,13R,16S,19R)-13-((1H-Indol-3-yl)methyl)-10-(4-aminobutyl)-4-(((1S,2R)-1-carboxy-2-hydroxypropyl)carbamoyl)-16-(4-hydroxybenzyl)-7-((R)-1-hydroxyethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaazacycloicosan-19-yl)amino)-1-oxo-3-phenylpropan-2-yl)amino)-2-oxoethyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetic acid xacetate salt
  • DOTATATE acetic acid
  • 2,2',2''-(10-(2-(((R)-1-(((4R,7S,10S,13R,16S,19R)-13-((1H-Indol-3-yl)methyl)-10-(4-aminobutyl)-4-(((1S,2R)-1-carboxy-2-hydroxypropyl)carbamoyl)-16-(4-hydroxybenzyl)-7-((R)-1-hydroxyethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaazacycloicosan-19-yl)amino)-1-oxo-3-phenylpropan-2-yl)amino)-2-oxoethyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetic acid xacetate salt
  • 4,7,10-TRICARBOXYMETHYL-1,4,7,10-TETRAAZA-CYCLODODECAN-1-YL-ACETYL-D-PHE-CYS-TYR-D-TRP-LYS-THR-CYS-THR-OH, (DISULFIDE BOND) ACETATE
  • 177943-89-4
  • C65H90N14O19S2
  • C65H90N14O19S2xC2H4O2