L371,257

Product Name: L371,257
CAS No.: 162042-44-6
Chemical Name: L371,257
Synonyms: 257;L-371;L371,257;L371,257,L 371,257;1-[1-[4-(1-acetylpiperidin-4-yl)oxy-2-methoxybenzoyl]piperidin-4-yl]-4H-3,1-benzoxazin-2-one;1-[4-[(1-Acetyl-4-piperidinyl)oxy]-2-methoxybenzoyl]-4-(2-oxo-2H-3,1-benzoxazin-1(4H)-yl)piperidine;2H-3,1-Benzoxazin-2-one, 1-[1-[4-[(1-acetyl-4-piperidinyl)oxy]-2-methoxybenzoyl]-4-piperidinyl]-1,4-dihydro-;1-(1-(4-((1-acetylpiperidin-4-yl)oxy)-2-methoxybenzoyl)piperidin-4-yl)-1,4-dihydro-2H-benzo[d][1,3]oxazin-2-one
CBNumber: CB8850593
Molecular Formula: C28H33N3O6
Formula Weight: 507.58
MOL File: 162042-44-6.mol

More

Less

L371,257 Property

Boiling point:: 728.9±60.0 °C(Predicted)
Density: 1.282±0.06 g/cm3(Predicted)
storage temp.: Store at RT
solubility: Soluble to 10 mM in DMSO with gentle warming
form: Powder
pka: 0.73±0.20(Predicted)
color: White to off-white

More

Less

Hazard and Precautionary Statements (GHS)

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML3899
Product name: L-371,257
Purity: ≥98% (HPLC)
Packaging: 10mg
Price: $179
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML3899
Product name: L-371,257
Purity: ≥98% (HPLC)
Packaging: 50mg
Price: $3200
Updated: 2025/07/31

Tocris

Product number: 2410
Product name: L-371,257
Purity: ≥99%(HPLC)
Packaging: 10
Price: $269
Updated: 2021/12/16

TRC

Product number: L352940
Product name: L-371,257
Packaging: 1mg
Price: $160
Updated: 2021/12/16

Usbiological

Product number: 255632
Product name: L-371,257
Packaging: 10mg
Price: $516
Updated: 2021/12/16

More

Less

L371,257 Chemical Properties,Usage,Production

Uses

L-371,257 is a potent antagonist of oxytocin-induced contractions of the rat uterus in vitro and in vivo and has significant oral bioavailability in rats.

Biological Activity

Potent, high affinity human oxytocin (OT) receptor antagonist (K i = 4.6 nM) that displays > 800-fold selectivity over human arginine vasopressin receptors V 1a and V 2 . Antagonizes oxytocin-induced contractions in isolated rat uterine tissue (pA 2 = 8.44) and in anesthetised rats following intravenous and intraduodenal administration. Orally active.

in vivo

Systemic administration of nonpenetrant oxytocin receptor antagonist L-371,257 (0.5 and 1.0 mg/kg; i.p. injection) stimulates weight gain in rats^[3].

Animal Model:	Six-hour fasted rats^[3]
Dosage:	0.5 and 1.0 mg/kg
Administration:	Intraperitoneal injection (a single) 30-45 minutes prior to the start of the dark cycle and access to food; Intraperitoneal injection (given repeatedly) over 6 days.
Result:	A single injection significantly stimulated weight gain at 0.5 and 1.0 mg/kg relative to vehicle treatment. When given repeatedly over 6 days, 0.5 mg/kg significantly stimulated body weight gain (10.5±2.2 g) relative to vehicle treatment (4.7±2.7 g).

storage

Store at RT

L371,257 Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

L371,257 Suppliers

China 45 Germany 1 United Kingdom 1 United States 7 Global 54

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15838
Advantage: 69

Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4757
Advantage: 55

EMMX Biotechnology LLC

Tel: 888-539-0666
Fax: 888-539-0666
Email: info@emmx.com
Country: United States
ProdList: 8447
Advantage: 60

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

Shanghai Rechem science Co., Ltd.

Tel: 021-31433387 15618786686
Fax: QQ:1369748377
Email: sales@rechemscience.com
Country: China
ProdList: 2986
Advantage: 58

Shanghai Chaolan Chemical Technology Center

Tel: 021-QQ：65489617 15618227136
Fax: 21-5161 9052
Email: Sales@ATKchemical.com
Country: China
ProdList: 9119
Advantage: 58

Beijing Solarbio Science & Tecnology Co., Ltd.

Tel: 010-50973130 18101056239
Email: 3193328036@qq.com
Country: China
ProdList: 29760
Advantage: 68

TargetMol Chemicals Inc.

Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Country: United States
ProdList: 32435
Advantage: 58

Wuhan Topule

Tel: +86-02787215551 +86-19945035818
Fax: 027-87215551
Email: 2936752263@qq.com
Country: China
ProdList: 7986
Advantage: 58

Hebei Weite Medical Technology Co., Ltd

Tel: 13180081292 13180081292
Email: contact@wetogethermed.com
Country: China
ProdList: 7944
Advantage: 58

162042-44-6, L371,257Related Search:

4-Cbz-Aminopiperidine 1-Acetyl-4-(methylamino)piperidine 4-Methoxysalicylamide 4-(4-METHYLPHENOXY)PIPERIDINE HYDROCHLORIDE 4-PHENOXYPIPERIDINE 4-[3-(Dimethylamino)propoxy]benzaldehyde 1-(4-ISOPROPOXYPHENYL)METHANAMINE 2,4-Dihydroxybenzamide 4-ANILINO-1-BENZYLPIPERIDINE 4-(3-METHOXYPHENOXY)PIPERIDINE 1-Acetylpiperidin-4-amine 4-(PIPERIDIN-4-YLOXY)BENZAMIDE (4-AMINO-PIPERIDIN-1-YL)-PHENYL-METHANONE Benzamide, N-(3-dimethylaminopropyl)-p-propoxy- 4-ETHOXY-N,N-DIETHYLBENZAMIDE CHEMBRDG-BB 9072047 4-AMINOCARBETHOXYPIPERIDINE 1-ACETYLPIPERIDIN-4-OL

L371,257

1-[4-[(1-Acetyl-4-piperidinyl)oxy]-2-methoxybenzoyl]-4-(2-oxo-2H-3,1-benzoxazin-1(4H)-yl)piperidine

1-[1-[4-(1-acetylpiperidin-4-yl)oxy-2-methoxybenzoyl]piperidin-4-yl]-4H-3,1-benzoxazin-2-one

2H-3,1-Benzoxazin-2-one, 1-[1-[4-[(1-acetyl-4-piperidinyl)oxy]-2-methoxybenzoyl]-4-piperidinyl]-1,4-dihydro-

257

L-371

L371,257,L 371,257

1-(1-(4-((1-acetylpiperidin-4-yl)oxy)-2-methoxybenzoyl)piperidin-4-yl)-1,4-dihydro-2H-benzo[d][1,3]oxazin-2-one

162042-44-6

C28H33N3O6