ChemicalBook > CAS DataBase List > Propylene carbonate

Propylene carbonate

Product Name
Propylene carbonate
CAS No.
108-32-7
Chemical Name
Propylene carbonate
Synonyms
PC;4-METHYL-1,3-DIOXOLAN-2-ONE;Propylene carbonat;1,2-propanediolcarbonate;2-Oxo-4-methyl-1, 3-dioxolan;1,3-Dioxolan-2-one, 4-methyl-;ARCONATE;Propylencarbonat;1,2-Propanediyl carbonate;Cyclic propylene carbonate
CBNumber
CB8852744
Molecular Formula
C4H6O3
Formula Weight
102.09
MOL File
108-32-7.mol
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Propylene carbonate Property

Melting point:
-55 °C (lit.)
Boiling point:
240 °C (lit.)
Density 
1.204 g/mL at 25 °C (lit.)
vapor pressure 
0.13 mm Hg ( 20 °C)
refractive index 
n20/D 1.421(lit.)
Flash point:
270 °F
storage temp. 
Store below +30°C.
solubility 
240g/l
form 
Liquid
pka
3.92[at 20 ℃]
Specific Gravity
1.209 (20/4℃)
color 
Clear
PH
7.0 (200g/l, H2O, 20℃)
Relative polarity
6
Odor
odorless
explosive limit
1.8-14.3%(V)
Water Solubility 
240 g/L (20 ºC)
λmax
λ: 235 nm Amax: 1.00
λ: 280 nm Amax: 0.50
λ: 300 nm Amax: 0.30
λ: 350 nm Amax: 0.05
λ: 375-400 nm Amax: 0.01
BRN 
107913
Dielectric constant
64.4（Ambient）
Stability:
Stable. Incompatible with strong oxidizing agents, acids, bases, reducing agents. Protect from contact with moist air or water.
InChIKey
RUOJZAUFBMNUDX-UHFFFAOYSA-N
LogP
-0.41 at 20℃
CAS DataBase Reference
108-32-7(CAS DataBase Reference)
NIST Chemistry Reference
Propylene carbonate(108-32-7)
EPA Substance Registry System
Propylene carbonate (108-32-7)
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Safety

Hazard Codes 
Xi
Risk Statements 
36
Safety Statements 
26-37/39
WGK Germany 
1
RTECS 
FF9650000
F 
3-10
Autoignition Temperature
851 °F
TSCA 
Yes
HS Code 
29209010
Hazardous Substances Data
108-32-7(Hazardous Substances Data)
Toxicity
LD50 orally in Rabbit: > 5000 mg/kg LD50 dermal Rabbit > 20000 mg/kg
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
8.07051
Product name
Propylene carbonate
Purity
for synthesis
Packaging
100ML
Price
$42.3
Updated
2025/07/31
Sigma-Aldrich
Product number
8.07051
Product name
Propylene carbonate
Purity
for synthesis
Packaging
1L
Price
$86.9
Updated
2025/07/31
Sigma-Aldrich
Product number
8.07051
Product name
Propylene carbonate
Purity
for synthesis
Packaging
25L
Price
$422.1
Updated
2025/07/31
Sigma-Aldrich
Product number
8.07051
Product name
Propylene carbonate
Purity
for synthesis
Packaging
200L
Price
$2410
Updated
2025/07/31
Sigma-Aldrich
Product number
310328
Product name
Propylene carbonate
Purity
anhydrous, 99.7%
Packaging
1l
Price
$158
Updated
2025/07/31
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Propylene carbonate Chemical Properties,Usage,Production

Chemical Properties

Propylene carbonate is a clear, colorless, mobile liquid, with a faint odor.

Uses

propylene carbonate is used in chemical reactions as a solvent, plasticizer, solubilizer, or dilutent. It is also used in the synthesis of solar cells as well as lithium ion batteries.

Production Methods

Propylene carbonate may be prepared by the reaction of sodium bicarbonate with propylene chlorohydrin.

General Description

Propylene carbonate is a cyclic carbonate that is commonly used as a solvent and as a reactive intermediate in organic synthesis. It is being considered as a potential electrochemical solvent due to its low vapor pressure, high dielectric constant and high chemical stability.
Propylene carbonate can be synthesized from propylene oxide and CO2. Optically active form of propylene carbonate can be prepared from the reaction between CO2 and racemic epoxides. Decomposition of propylene carbonate on the graphite electrode in lithium batteries results in the formation of a lithium intercalated compound.

Flammability and Explosibility

Not classified

Pharmaceutical Applications

Propylene carbonate is used mainly as a solvent in oral and topical pharmaceutical formulations.
In topical applications, propylene carbonate has been used in combination with propylene glycol as a solvent for corticosteroids. The corticosteroid is dissolved in the solvent mixture to yield microdroplets that can then be dispersed in petrolatum.Propylene carbonate has been used as a dispensing solvent in topical preparations.
Propylene carbonate has also been used in hard gelatin capsules as a nonvolatile, stabilizing, liquid carrier. For formulations with a low dosage of active drug, a uniform drug content may be obtained by dissolving the drug in propylene carbonate and then spraying this solution on to a solid carrier such as compressible sugar; the sugar may then be filled into hard gelatin capsules
Propylene carbonate may additionally be used as a solvent, at room and elevated temperatures, for many cellulose-based polymers and plasticizers. Propylene carbonate is also used in cosmetics.

Safety

Propylene Carbonate is listed in The Design for the Environment (DfE) Safer Chemistry Program by the EPA as a Solvent category and indicated by the Green circle, meaning the chemical has been verified to be of low concern for human and environmental health based on experimental and modeled data.
In animal studies, propylene carbonate was found to cause tissue necrosis after parenteral administration.
(mouse, oral): 20.7 g/kg
(mouse, SC): 15.8 g/kg
(rat, oral): 29 g/kg
(rat, SC): 11.1 g/kg

storage

Propylene carbonate and its aqueous solutions are stable but may degrade in the presence of acids or bases, or upon heating;
Store in a well-closed container in a cool, dry place.

Purification Methods

It is manufactured by reaction of 1,2-propylene oxide with CO2 in the presence of a catalyst (quaternary ammonium halide). Contaminants include propylene oxide, carbon dioxide, 1,2-and 1,3-propanediols, allyl alcohol and ethylene carbonate. It can be purified by percolation through molecular sieves (Linde 5A, dried at 350o for 14hours under a stream of argon), followed by distillation under a vacuum. [Jasinski & Kirkland Anal Chem 39 163 1967.] It can be stored over molecular sieves under an inert gas atmosphere. When purified in this way it contains less than 2ppm of water. Activated alumina and dried CaO have also been used as drying agents prior to fractional distillation under reduced pressure. It has been dried with 3A molecular sieves and distilled under nitrogen in the presence of p-toluenesulfonic acid, then redistilled and the middle fraction collected. [Beilstein 19 III/IV 1564, 19/4 V 21.]

Incompatibilities

Propylene carbonate hydrolyzes rapidly in the presence of strong acids and bases, forming mainly propylene oxide and carbon dioxide. Propylene carbonate can also react with primary and secondary amines to yield carbamates.

Toxics Screening Level

The current initial threshold screening level (ITSL) for propylene carbonate is 700 μg/m3 based on an annual averaging time.

Regulatory Status

Included in the FDA Inactive Ingredients Database (topical ointments). Included in the Canadian List of Acceptable Nonmedicinal Ingredients.

Propylene carbonate Preparation Products And Raw materials

Raw materials

3-Chloro-1-propanol (+)-MENTHYL CHLOROFORMATE Propylene glycol Propylene oxide

Preparation Products

2-Bromo-9,9-dimethylfluorene Ammonium chloride Propylene glycol Dimethyl carbonate
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View Lastest Price from Propylene carbonate manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
Propylene carbonate 108-32-7
Price
US $0.00/KG
Min. Order
250KG
Purity
98%min
Supply Ability
30tons/month
Release date
2023-02-21
Hebei Chuanghai Biotechnology Co., Ltd
Product
Propylene carbonate 108-32-7
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100 TON
Release date
2024-11-01
HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
Product
Propylene carbonate 108-32-7
Price
US $500.00-300.00/ton
Min. Order
1ton
Purity
99%
Supply Ability
5000
Release date
2024-08-23

108-32-7, Propylene carbonate Related Search:

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