ChemicalBook > CAS DataBase List > Squalene

Squalene

Product Name
Squalene
CAS No.
111-02-4
Chemical Name
Squalene
Synonyms
Supraene;SQUALENE OIL;trans-squalene;(E,E,E,E)-Squalene;Squalen;All-trans-Squalene;AddaVax;Spinacen;squalcnc;SPINACENE
CBNumber
CB8855316
Molecular Formula
C30H50
Formula Weight
410.72
MOL File
111-02-4.mol
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Squalene Property

Melting point:
−75 °C(lit.)
Boiling point:
285 °C25 mm Hg(lit.)
Density 
0.858 g/mL at 25 °C(lit.)
vapor pressure 
0Pa at 25℃
refractive index 
n20/D 1.494(lit.)
Flash point:
>230 °F
storage temp. 
2-8°C
solubility 
DMSO : 16.67 mg/mL (40.59 mM; Need ultrasonic)H2O : < 0.1 mg/mL (insoluble)
form 
liquid
color 
light yellow
Odor
oil, faint odor
Water Solubility 
<0.1 g/100 mL at 19 ºC
Merck 
14,8768
BRN 
1728919
LogP
14.12 at 24℃
CAS DataBase Reference
111-02-4(CAS DataBase Reference)
NIST Chemistry Reference
2,6,10,14,18,22-Tetracosahexaene, 2,6,10,15,19,23-hexamethyl-, (all-E)-(111-02-4)
EPA Substance Registry System
Squalene (111-02-4)
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Safety

Safety Statements 
24/25
WGK Germany 
2
RTECS 
XB6010000
F 
8-10-23
TSCA 
Yes
HS Code 
29012980
Hazardous Substances Data
111-02-4(Hazardous Substances Data)
Toxicity
mouse,LD50,intravenous,1800mg/kg (1800mg/kg),Japanese Journal of Cancer Research. Vol. 76, Pg. 1021, 1985.
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H304May be fatal if swallowed and enters airways

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
S3626
Product name
Squalene
Purity
≥98%, liquid
Packaging
10ml
Price
$59.3
Updated
2024/03/01
Sigma-Aldrich
Product number
Y0002131
Product name
Squalene
Purity
European Pharmacopoeia (EP) Reference Standard
Packaging
Y0002131
Price
$156
Updated
2024/03/01
Sigma-Aldrich
Product number
S3626
Product name
Squalene
Purity
≥98%, liquid
Packaging
1l
Price
$882
Updated
2024/03/01
Sigma-Aldrich
Product number
442785
Product name
Squalene
Purity
analyticalstandard
Packaging
1000mg
Price
$303
Updated
2024/03/01
TCI Chemical
Product number
H0097
Product name
Squalene
Purity
>98.0%(GC)
Packaging
25mL
Price
$21
Updated
2024/03/01
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Squalene Chemical Properties,Usage,Production

Chemical Properties

clear colourless to faint yellow oil

Uses

Squalene is a natural triterpene that plays an important role in the synthesis of cholesterol, steroid hormones, and vitamin D in the human body. Squalene is commonly used as a biochemical precursor i n the preparation of steroids. Squalene is also a natural moisturizer with low acute toxicity and is not significant human skin irritants or sensitizers.

Uses

cosmetic and pharmaceutical excipient

Uses

Bactericide; intermediate in manufacture of pharmaceuticals, organic coloring materials, rubber chemicals, aromatics and surface active agents.

Production Methods

Squalene is extracted from shark liver or synthesized from hexaphenyl-1,4-butanediyldiphosphonium dibromide and 6,10-dimethyl-5,9-undecadien-2-one (geranylacetone, industrial intermediate in the vitamin E synthesis).

Definition

ChEBI: A triterpene consisting of 2,6,10,15,19,23-hexamethyltetracosane having six double bonds at the 2-, 6-, 10-, 14-, 18- and 22-positions with (all-E)-configuration.

General Description

Clear, slightly yellow liquid with a faint odor. Density 0.858 g / cm3.

Air & Water Reactions

May become discolored on exposure to air. Insoluble in water.

Reactivity Profile

(all-E)-2,6,10,15,19,23-Hexamethyl-2,6,10,14,18,22-tetracosahexaene is incompatible with strong oxidizing agents. .

Health Hazard

ACUTE/CHRONIC HAZARDS: When heated to decomposition (all-E)-2,6,10,15,19,23-Hexamethyl-2,6,10,14,18,22-tetracosahexaene emits toxic fumes of carbon monoxide and carbon dioxide.

Fire Hazard

(all-E)-2,6,10,15,19,23-Hexamethyl-2,6,10,14,18,22-tetracosahexaene is probably combustible.

Flammability and Explosibility

Non flammable

Biochem/physiol Actions

Squalene is a biosynthetic precursor to all steroids. It acts as a cytoprotective agent to normal cells exposed to carcinogens and antitumor agents. Squalene helps in equalizing the blood cholesterol levels. It increases the production of HDL (high density lipoprotein) and the excretion of LDL (low density lipoprotein). This helps in reducing the risk of heart disease and protects the less stable body fats from oxidation. It is also used in treating hypercholesterolemia. Squalene is known to improve the efficiency of cholesterol lowering drugs. It also serves as an antioxidant by preventing the effects of free radical. It protects skin from drying and other environmental conditions such as oxidation, ultraviolet rays and pollutants. Squalene is known to promote wound healing.

target

COX | STAT | FOXP3 | Nrf2 | SOD | GPx

Squalene Preparation Products And Raw materials

Raw materials

filter paper Squalene Oils, shark-liver Squalane (2S)-1-(3-Acetylthio-2-methyl-1-oxopropyl)-L-proline

Preparation Products

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Squalene Suppliers

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View Lastest Price from Squalene manufacturers

Hebei Zhuanglai Chemical Trading Co Ltd
Product
Squalene 111-02-4
Price
US $79.00-38.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20ton
Release date
2024-11-20
BINBO BIOLOGICAL CO.,LTD
Product
Vegan Squalene 111-02-4
Price
US $0.00/kg
Min. Order
1kg
Purity
50% 70% 80%
Supply Ability
1000 kg
Release date
2024-04-23
SUZHOU NMT BIOTECH CO.,LTD
Product
Squalene 111-02-4
Price
US $0.00-0.00/kg
Min. Order
200kg
Purity
50%,70%,98%
Supply Ability
20 tons
Release date
2024-10-11

111-02-4, SqualeneRelated Search:

hydroxygenkwanin beta-Eudesmol syn-coll Fullerene C70 CEPHALIN Squalane 2,6,10,15,19,23-HEXAMETHYL-2,6,10,14,18,22-TETRACOSAHEXAENE 1,5,9,13-TETRADECATETRAENE 1,5,9-DECATRIENE TRIISOBUTYLENE 2,7-dimethyl-2,6-octadiene Squalene 2 6-DIMETHYL-2 CIS-6-OCTADIENE 2,6-OCTADIENE 3,7-DECADIENE SQUALENE, [4,8,12,13,17,21-3H] 6-METHYL-1,5-HEPTADIENE SQUALENE, [1,5,9,14,20,24-14C] Squalene Oil

  • 2,6,10,15,19,23-HEXAMETHYL-2, 6, 10, 14, 18, 22-TETRACOSAHEXENE
  • (all-e)-2,6,10,15,19,23-hexamethyl-2,6,10,14,18,22-tetracosahexaene
  • (E,E,E,E)-Squalene
  • 2,6,10,15,19,23-Hexamethyltetracosa-2,6,10,14,18,22-hexaene
  • 2,6,10,15,19,23-hexamethyl-tetracosa-2,6,10,14,18,22-hexane
  • 2,6,10,15,19,23-Hexamethyltetracosahexa-2,6,10,14,18,22-ene
  • 6,10,14,18,22-Tetracosahexaene,2,6,10,15,19,23-hexamethyl-,(all-E)-2
  • All-trans-Squalene
  • Spinacen
  • Squalen
  • Supraene
  • trans-Spinacene
  • SQUALENE OIL
  • SPINACENE
  • trans-squalene
  • Squalene,2,6,10,15,19,23-Hexamethyl-2,6,10,14,18,22-tetracosahexaene
  • Squalene, 99+% 100ML
  • squalcnc
  • (6E,10E,14E,18E)-2,6,10,15,19,23-Hexamethyltetracosa-2,6,10,14,18,22-hexaene
  • Nikko Squalane EX
  • triacontahexaene
  • (6E,10E,14E,18E)-2,6,10,15,19,23-Hexamethyl-2,6,10,14,18,22-tetracosahexaene
  • 14,18,22-tetracosahexaene,2,6,10,15,19,23-hexamethyl-(all-e)-10
  • 2,6,10,15,19,23-hexamethyltetracosa-
  • SQUALENE, 1000MG, NEAT
  • Squalene, 99+%
  • (2E,6E,10E,14E,18E)-2,6,10,15,19,23-hexamethyl-2,6,10,14,18,22-Tetracosahexaene
  • 2,6,10,14,18,22-Tetracosahe
  • SQUALENE WITH GC
  • 2,6,10,14,18,22-Tetracosahexaene, 2,6,10,15,19,23-hexamethyl-, (2E,6E,10E,14E,18E)-
  • Squalene: (2,610,15.19,23-Hexamethyltetracosahexane)
  • 2, 6, 10, 15, 19, 23-hexamethyl-2, 6, 10, 14, 18, 22-tetracosahexanee
  • Squalene&gt
  • Squalene Squalene
  • AddaVax
  • Super Squalene
  • 2,6,10,14,18,22-Tetracosahexaene, 2,6,10,15,19,23-hexamethyl-, (6E,10E,14E,18E)-
  • (E)-squalene
  • TIANFU-CHEM -(all-E)-2,6,10,15,19,23-Hexamethyl-2,6,10,14,18,22-tetracosahexaene
  • (all-E)-2,6,10
  • Vegan Squalene
  • Squalene CRS/A1A
  • Squalene in isooctane
  • C16973700 Squalene
  • 111-02-4
  • 7级111-02-4
  • C30H50
  • CH32CCHCH2CH2CCH32CHCH22
  • Enzyme Inhibitors
  • Cancer Research
  • BioChemical
  • Chemopreventive Agents
  • Terpenes (Others)
  • Terpenes
  • Biochemistry
  • Terpenes
  • Terpenes (Others)
  • Triterpenoids