Occurrence Physical and chemical properties Squalane application Preparation Cooling Experiment
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Squalane

Occurrence Physical and chemical properties Squalane application Preparation Cooling Experiment
Product Name
Squalane
CAS No.
111-01-3
Chemical Name
Squalane
Synonyms
ROBANE;Synthetic squalane;Dermane;Dodecahydrosqualene;2,6,10,15,19,23-HEXAMETHYLTETRACOSANE;Romane;COSBIOL;Squalan;SQUALANE;SPINACANE
CBNumber
CB8469063
Molecular Formula
C30H62
Formula Weight
422.81
MOL File
111-01-3.mol
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Squalane Property

Melting point:
-38 °C (lit.)
Boiling point:
176 °C/0.05 mmHg (lit.)
Density 
0.81 g/mL at 25 °C (lit.)
refractive index 
n20/D 1.452(lit.)
Flash point:
424 °F
storage temp. 
2-8°C
solubility 
chloroform: soluble100mg/mL, clear
color 
Clear Colourless
Water Solubility 
Not miscible or difficult to mix in water.
Merck 
14,8767
BRN 
776019
Stability:
Stable. Combustible. Incompatible with strong oxidizing agents.
InChIKey
PRAKJMSDJKAYCZ-UHFFFAOYSA-N
LogP
17 at 25℃
CAS DataBase Reference
111-01-3(CAS DataBase Reference)
NIST Chemistry Reference
Tetracosane, 2,6,10,15,19,23-hexamethyl-(111-01-3)
EPA Substance Registry System
Squalane (111-01-3)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
3
RTECS 
XB6070000
TSCA 
Yes
HS Code 
29012990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
234311
Product name
Squalane
Purity
97%
Packaging
5g
Price
$50.1
Updated
2024/03/01
Sigma-Aldrich
Product number
1619505
Product name
Squalane
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
500mg
Price
$474
Updated
2024/03/01
TCI Chemical
Product number
H0096
Product name
Squalane
Purity
>98.0%(GC)
Packaging
25mL
Price
$19
Updated
2024/03/01
TCI Chemical
Product number
H0096
Product name
Squalane
Purity
>98.0%(GC)
Packaging
100mL
Price
$45
Updated
2024/03/01
Alfa Aesar
Product number
A17931
Product name
Squalane, 98%
Packaging
100g
Price
$53.3
Updated
2023/06/20
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Squalane Chemical Properties,Usage,Production

Occurrence

Squalane is obtained through the hydrogenation of squalene, and can be used as the oily raw materials of balsam, nutritional emulsion and other basic cosmetics. Squalene was obtained from the liver oil of Centrophorus or other deep-sea shark. Initially, it is the byproduct during the Vitamin A production process from shark liver oil. In recent years, it has been found that unsaponifiable oil of olive oil is rich in squalene, which can be used as the raw material of production of squalane (i.e., fully hydrogenated squalene).

Physical and chemical properties

Refined squalane is a colorless, odorless, inert and transparent oily viscous liquid. Slightly soluble in methanol, ethanol, acetone and glacial acetic acid. It is miscible with benzene, chloroform, carbon tetrachloride, petroleum ether, ether, mineral oil and other animal and vegetable oils. The relative density (15 °C/ 4 ℃) 0.812, refractive index (15 ℃) 1.4530, iodine value 0 ~ 5, saponification value 0 ~ 5, acid value 0 ~ 0.2, freezing point -38 ℃, boiling point 350 ℃. It is stable in the air, but can be slowly oxidized upon the action of sunlight. Sebaceous glands can synthesize squalene. Sebum contain squalene at a content of 1% in children and up to 10% in adult; sebum contains a squalane mass fraction of about 2%. Its permeability, lubricity and breathability is better than other fats, matching well with most cosmetic raw materials.

Squalane application

  1. Squalane is widely used as a cosmetic base and finishing cosmetics, precise machinery lubricants, perlite agent of medical ointment and advanced soap.
  2. Squalane is a natural product, being inert and non-toxic. It has good affinity to human skin without irritating the skin and causing allergies. It can accelerate the penetration of other actives into the skin. Squalane is a high-grade cosmetic oily raw materials, such as various types of creams and lotions, eyeliners, eyeshadow and conditioner. Cosmetics is mostly natural product extracted directly from cod liver oil. Synthetic products have stimulating effect on the human body, only used as lubricants and UV agents.
  3. Squalane is the most commonly used standard non-polar fixative with its polarity being set to zero. Such fixed liquid and component molecules is the dispersion force, mainly used for the separation of general hydrocarbons and non-polar compounds.

Preparation

  1. It can be refined directly from the cod liver oil with refinement the first vacuum decompression obtained crude squalane, and then in the nickel catalyst, high temperature, high pressure hydrogenation, remove the double bond part, and then vacuum distillation available.
  2. Synthesis method. Take isoprene as raw material; first apply chlorination of isoprene, generating methyl heptanone, followed by dehydrogenation to generate linalool; further apply linalool and geranyl acetone, finally generating squalane.
  3. Squalene can be used as raw material with direct hydrogenation to obtain it.
  4. Take olive oil as raw material, extract the squalene, and then perform hydrogenation to obtain it.
  5. Linalool can react with ethyl acetoacetate to generate 3, 7, 11-trimethyl-dodecane-6, 10-dien-1-yn-3-ol; further use cuprous oxide as a catalyst for oxidation and coupling, hydrogenation to obtain the finished product of squalane.

Cooling Experiment

This product at -55 ℃ without losing its liquidity. Test based on the freezing-point determination method. The thermometer used was a low flow point thermometer, glass bath D, and put into dry ice and acetone for cooling.

Chemical Properties

viscous colourless liquid

Uses

health foods

Uses

Squalane has been used: as solvent in the synthesis of Europium dibenzoylmethide triethylammonium, brightest known triboluminescent (TL) material;as lubricant for fatty acid surfactant films adsorbed on iron oxide surfaces

Uses

Lubricant, transformer oil. Ingredient of watch and chronometer oils. Perfume fixative. In pharmacy and cosmetics as skin lubricant, ingredient of suppositories, carrier of lipid-soluble drugs.

Uses

squalane is an excellent moisturizer and lubricant, it softens and smoothes the skin while also replenishing skin lipids. Its compatibility with skin lipids can be attributed to the fact that human sebum is made up of 25 percent squalane. Squalane has traditionally been obtained by hydrogenation of shark liver oil or other natural oils. Components found in fish oils may reduce skin irritation and allergic responses. It can also be derived from plant sources or synthetically manufactured.

Definition

A saturated hydrocarbon.

General Description

Dielectrophoretic deformation of thin liquid fillm of squalane has been investigated. Microfluidized squalenes are efficient adjuvants, eliciting both humoral and cellular immune responses.

Purification Methods

Purify squalane by fractional distillation in vacuo or evaporative distillation. It is soluble in pet ether, *C6H6, Et2O and CHCl3, slightly soluble in alcohols, Me2CO and AcOH but insoluble in H2O. Small quantities can be purified by TLC as for squalene below. It is used as a marker in GLC and HPLC. [Staudinger & Leupold Helv Chim Acta 15 223 1932, Sax & Stross Anal Chem 29 1700 1951, Mandai et al. Tetrahedron Lett 22 763 1981, Beilstein 1 IV 593.]

Squalane Preparation Products And Raw materials

Raw materials

Preparation Products

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Squalane Suppliers

Hebei Zhentian food additives Co., LTD
Tel
0319-5925599 13373390591
Email
13373390591@163.com
Country
China
ProdList
11447
Advantage
58
Jishui Jianmin Natural Flavor Oil Factory
Tel
0796-8186259 19870606785
Email
1805709358@qq.com
Country
China
ProdList
333
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
4006608290; 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40241
Advantage
62
future industrial shanghai co., ltd
Tel
400-0066400 13621662912
Fax
021-55660885
Email
sales@jonln.com
Country
China
ProdList
1998
Advantage
65
Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30132
Advantage
84
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24539
Advantage
81
BeiJing Hwrk Chemicals Limted
Tel
0757-86329057 18501085097
Fax
010-89508210
Email
sales3.gd@hwrkchemical.com
Country
China
ProdList
7508
Advantage
55
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44751
Advantage
61
JinYan Chemicals(ShangHai) Co.,Ltd.
Tel
13817811078
Fax
86-021-50426522,50426273
Email
sales@jingyan-chemical.com
Country
China
ProdList
9984
Advantage
60
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View Lastest Price from Squalane manufacturers

Hebei Yime New Material Technology Co., Ltd.
Product
Squalane oil 111-01-3
Price
US $58.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
1000kg
Release date
2023-11-16
Hebei Yime New Material Technology Co., Ltd.
Product
Plant squalane 111-01-3
Price
US $35.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
1000kg/week
Release date
2024-01-10
Sinoway Industrial co., ltd.
Product
Squalane 111-01-3
Price
US $0.00/Kg/Bag
Min. Order
1Kg/Bag
Purity
92% up, High Density
Supply Ability
20 tons
Release date
2023-06-01

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