4-Amino-1-methyl-3-propyl-5-pyrazolecarboxamide

Product Name: 4-Amino-1-methyl-3-propyl-5-pyrazolecarboxamide
CAS No.: 139756-02-8
Chemical Name: 4-Amino-1-methyl-3-propyl-5-pyrazolecarboxamide
Synonyms: 4-AMINO-1-METHYL-3-PROPYL-1H-PYRAZOLE-5-CARBOXAMIDE;AILDE-006;-3-n-propyL;Sildenafil Impurity 3;5-pyrazolecarboxamide;Sildenafil Impurity IV-3;1H-Pyrazole-5-carboxamide,4-am;Sildenafil AMino AMide IMpurity;4-Amino-1-methyl-3-propyl-1H-pyrazo;4-AMINO-1-METHYL-3-N-PROPYL-5-PYRAZOLECA
CBNumber: CB8855604
Molecular Formula: C8H14N4O
Formula Weight: 182.22
MOL File: 139756-02-8.mol

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4-Amino-1-methyl-3-propyl-5-pyrazolecarboxamide Property

Melting point:: 98-101 °C(lit.)
Boiling point:: 325.9±42.0 °C(Predicted)
Density: 1.32±0.1 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
solubility: Chloroform, Ethyl Acetate, Methanol
form: Solid
pka: 15.30±0.50(Predicted)
color: Off-White to Pale Beige
InChI: InChI=1S/C8H14N4O/c1-3-4-5-6(9)7(8(10)13)12(2)11-5/h3-4,9H2,1-2H3,(H2,10,13)
InChIKey: PZMXDLWWQHYXGY-UHFFFAOYSA-N
SMILES: N1(C)C(C(N)=O)=C(N)C(CCC)=N1
CAS DataBase Reference: 139756-02-8(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3
HS Code: 2933.19.4300

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 535745
Product name: 4-Amino-1-methyl-3-n-propyl-5-pyrazolecarboxamide
Purity: 96%
Packaging: 5g
Price: $56.03
Updated: 2025/07/31

TCI Chemical

Product number: A2857
Product name: 4-Amino-1-methyl-3-propylpyrazole-5-carboxamide
Purity: >98.0%(HPLC)(T)
Packaging: 5g
Price: $98
Updated: 2025/07/31

TCI Chemical

Product number: A2857
Product name: 4-Amino-1-methyl-3-propylpyrazole-5-carboxamide
Purity: >98.0%(HPLC)(T)
Packaging: 25g
Price: $291
Updated: 2025/07/31

TRC

Product number: A617415
Product name: 4-Amino-1-methyl-3-propyl-1H-pyrazole-5-carboxamide
Packaging: 5g
Price: $200
Updated: 2021/12/16

Usbiological

Product number: A1379
Product name: 4-Amino-1-methyl-3-propyl-1H-pyrazole-5-carboxamide
Packaging: 1g
Price: $333
Updated: 2021/12/16

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4-Amino-1-methyl-3-propyl-5-pyrazolecarboxamide Chemical Properties,Usage,Production

Chemical Properties

Off-White Solid

Uses

An impurity in the synthesis of Sildenafil.

Uses

A potent hypolipidemic agent. A possible inhibitor of phosphodiesterase 1

Definition

ChEBI: 4-amino-1-methyl-3-propylpyrazole-5-carboxamide is a multi-substituted pyrazolecarboxamide used in the industrial synthesis of sildenafil. It is a member of pyrazoles and a monocarboxylic acid amide.

Synthesis

139756-01-7

139756-02-8

Step 7 Synthesis of 4-amino-1-methyl-3-n-propyl-1H-pyrazole-5-carboxamide: 1-methyl-4-nitro-3-propyl-1H-pyrazole-5-carboxamide (14.7 g, 69.3 mmol) was suspended in ethyl acetate (130 mL) and 10% palladium/carbon catalyst (3.3 g) was added. The reaction mixture was stirred overnight at 50 °C and 4 atm hydrogen pressure. Upon completion of the reaction, it was cooled to room temperature, the catalyst was removed by filtration, and the catalyst was washed with ethyl acetate. The combined filtrates were dried with anhydrous magnesium sulfate, filtered and concentrated under reduced pressure to give 4-amino-1-methyl-3-n-propyl-1H-pyrazole-5-carboxamide (13.8 g, 98% yield) as a white solid. The product was confirmed by 1H NMR (300 MHz, CDCl3): δ 4.12 (s, 3H), 2.84 (s, 2H), 2.55 (t, 2H, J = 7.2 Hz), 1.71-1.61 (m, 2H), 0.99 (t, 3H, J = 7.2 Hz); LC-MS showed m/z = 183 (MH)+.

References

[1] Patent: US2008/194529, 2008, A1. Location in patent: Page/Page column 57
[2] Patent: WO2014/131855, 2014, A1. Location in patent: Page/Page column 81
[3] Patent: WO2016/20307, 2016, A1. Location in patent: Page/Page column 51
[4] Patent: CN103044330, 2018, B. Location in patent: Paragraph 0025; 0031-0032; 0034-0035
[5] Patent: WO2015/114647, 2015, A1. Location in patent: Page/Page column 47; 48

4-Amino-1-methyl-3-propyl-5-pyrazolecarboxamide Preparation Products And Raw materials

Raw materials

Preparation Products

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4-Amino-1-methyl-3-propyl-5-pyrazolecarboxamide Suppliers

Americas 1 Australia 1 Belgium 1 Canada 2 China 316 Europe 1 Germany 6 India 33 Japan 4 Poland 1 Slovakia 1 South Korea 2 Spain 1 Sweden 2 Switzerland 3 Ukraine 1 United Kingdom 12 United States 50 Global 438

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View Lastest Price from 4-Amino-1-methyl-3-propyl-5-pyrazolecarboxamide manufacturers

Hebei Chuanghai Biotechnology Co,.LTD

Product: 4-Amino-1-methyl-3-propyl-5-pyrazolecarboxamide 139756-02-8
Price: US $19.00/KG
Min. Order: 1KG
Purity: 99.%
Supply Ability: 50 ton
Release date: 2024-08-23

Zhuozhou Wenxi import and Export Co., Ltd

Product: 4-Amino-1-methyl-3-propyl-1H-pyrazole-5-carboxamide 139756-02-8
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-11

Zhuozhou Wenxi import and Export Co., Ltd

Product: 4-Amino-1-methyl-3-propyl-1H-pyrazole-5-carboxamide 139756-02-8
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-09

139756-02-8, 4-Amino-1-methyl-3-propyl-5-pyrazolecarboxamideRelated Search:

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4-amino-1-methyl-3-propyl-5-pyrazolecarboxamide

4-AMINO-1-METHYL-3-PROPYL PYRAZOLE-5-CARBOXAMIDE

1-METHYL-3-PROPYL-4-AMINOPYRAZOLE-5-CARBOXAIMDE

1H-Pyrazole-5-carboxamide,4-amino-1-methyl-3-n-propyl

4-AMINO-1-METHYL-3-N-PROPYL-5-PYRAZOLECA

-3-n-propyL

Sildenafil Impurity IV-3

4-Amino-1-methyl-3-propyl-5-pyrazolecarboxam

4-amino-1-methyl-3-propyl-1H-pyrazole-5-carboxamide HCl

4-Amino-1-methyl-3-n-propyl-5-pyrazolecarboxamide,4-Amino-2-methyl-5-propyl-2H-pyrazole-3-carboxylic acid amide

1H-Pyrazole-5-carboxaMide,4-aMino-1-Methyl-3-propyl-

4-Amino-1-methyl-3-n-propyl-5-pyrazolecarboxamide 96%

4-amino-2-methyl-5-propyl-3-pyrazolecarboxamide

1H-Pyrazole-5-carboxamide,4-am

Sildenafil AMino AMide IMpurity

Sildenafil Impurity 3

4-Amino-1-methyl-3-propyl-5-pyrazolecarboxamid

AILDE-006

(E)-3-(((5-carbamoyl-1-methyl-3-prop yl-1H-pyrazol-4-yl)imino)methyl)-4- ethoxybenzenesulfonyl chloride

4-AMINO-1-METHYL-3-N-PROPYL PYRAZOLE-5-C

4-Amino-1-methyl-3-propyl-1H-pyrazo

5-pyrazolecarboxamide

Sildenafil Citrate Impurity-1Q: What is Sildenafil Citrate Impurity-1 Q: What is the CAS Number of Sildenafil Citrate Impurity-1 Q: What is the storage condition of Sildenafil Citrate Impurity-1 Q: What are the applications of Sildenafil Citrate Impurity-1

4-Amino-1-methyl-3-propyl-1H-pyrazol-5-carboxamide

4-amino-1-methyl-3-n-propyl - 1H-pyrazole-5-carboxyamide

4-Amino-1-methyl-3-<i>n</i>-propyl-5-pyrazolecarboxamide

139756-02-8

7365-44-9

60970-54-7

139756-22-1

C8H14N4O

Pyrazoles

Heterocyclic Compounds

Amines

Heterocycles

Nucleotides and Nucleosides

Bases & Related Reagents

Nucleotides

139756-02-8

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