2-amino-alpha,alpha,alpha-trifluoro-p-creso

Product Name: 2-amino-alpha,alpha,alpha-trifluoro-p-creso
CAS No.: 454-81-9
Chemical Name: 2-amino-alpha,alpha,alpha-trifluoro-p-creso
Synonyms: T5394155;5-Amino-2-trifluoromethyl-phenol;4-(Trifluoromethyl)-2-aminophenol;3-AMINO-4-HYDROXYBENZOTRIFLUORIDE;2-amino-4-(trifluoromethyl)phenol;2-azanyl-4-(trifluoromethyl)phenol;Phenol, 2-amino-4-(trifluoromethyl)-;2-Hydroxy-5-(trifluoromethyl)aniline;3-Amino-4-hydroxybenzotrifluoride 95%;2-Amino-4-(trifluoromethyl)phenol, HCl
CBNumber: CB8872568
Molecular Formula: C7H6F3NO
Formula Weight: 177.12
MOL File: 454-81-9.mol

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2-amino-alpha,alpha,alpha-trifluoro-p-creso Property

Melting point:: 121-122 °C(Solv: benzene (71-43-2))
Boiling point:: 234.5±40.0 °C(Predicted)
Density: 1.432±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
form: Solid
pka: 8.36±0.18(Predicted)
InChI: InChI=1S/C7H6F3NO/c8-7(9,10)4-1-2-6(12)5(11)3-4/h1-3,12H,11H2
InChIKey: BHTKIYIEMXRHGL-UHFFFAOYSA-N
SMILES: C1(O)=CC=C(C(F)(F)F)C=C1N

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Safety

HS Code: 2908190090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: A631250
Product name: 2-Amino-4-(trifluoromethyl)phenol
Packaging: 1g
Price: $110
Updated: 2021/12/16

Usbiological

Product number: 260395
Product name: 3-Amino-4-hydroxybenzotrifluoride
Packaging: 1g
Price: $523
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA44858
Product name: 3-Amino-4-hydroxybenzotrifluoride
Packaging: 5G
Price: $420
Updated: 2021/12/16

ChemScene

Product number: CS-W021552
Product name: 2-Amino-4-(trifluoromethyl)phenol
Purity: >98.0%
Packaging: 25g
Price: $506
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0093906
Product name: 3-AMINO-4-HYDROXYBENZOTRIFLUORIDE
Purity: 95.00%
Packaging: 1G
Price: $837.99
Updated: 2021/12/16

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2-amino-alpha,alpha,alpha-trifluoro-p-creso Chemical Properties,Usage,Production

Uses

2-Amino-4-(trifluoromethyl)phenol is used in the studies on the structure activity relationship of benzoxazolone carboxamides as potent acid ceramidase inhibitors.

Synthesis

400-99-7

454-81-9

The general procedure for the synthesis of 2-amino-4-trifluoromethylphenol from 2-nitro-4-trifluoromethylphenol was as follows: 2-nitro-4-trifluoromethylphenol (340 μL, 2.41 mmol) was dissolved in methanol (50 mL), and catalytically hydrogenated at room temperature and atmospheric pressure using a 10% Pd/C catalyst cartridge through an H-Cube hydrogenation reactor. Upon completion of the reaction, the reaction solution was concentrated under reduced pressure to give 2-amino-4-trifluoromethylphenol (438 mg, 100% yield) as a light brown solid. Mass spectrum (chemical ionization, m/z): [M+H]+ 178, [M-H]- 176; 1H NMR (CDCl3): δ 6.96 (d, J=2.0 Hz, 1H), 6.89-6.94 (m, 1H), 6.74 (d, J=8.2 Hz, 1H), 4.10 (br s, 2H).

References

[1] Patent: WO2009/37293, 2009, A1. Location in patent: Page/Page column 52
[2] Patent: WO2009/37294, 2009, A1. Location in patent: Page/Page column 93
[3] Patent: US2014/142114, 2014, A1. Location in patent: Paragraph 0859; 0860
[4] Phosphorus, Sulfur and Silicon and the Related Elements, 2009, vol. 184, # 3, p. 651 - 659
[5] Patent: WO2005/85202, 2005, A1. Location in patent: Page/Page column 53-54

2-amino-alpha,alpha,alpha-trifluoro-p-creso Preparation Products And Raw materials

Raw materials

Preparation Products

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2-amino-alpha,alpha,alpha-trifluoro-p-creso Suppliers

China 110 India 1 Ukraine 1 United Kingdom 4 United States 11 Global 127

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Hangzhou Yuhao Chemical Technology Co., Ltd

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View Lastest Price from 2-amino-alpha,alpha,alpha-trifluoro-p-creso manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 2-amino-alpha,alpha,alpha-trifluoro-p-creso 454-81-9
Price: US $20.00-7.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 200000KG
Release date: 2024-08-06

Career Henan Chemical Co

Product: 2-amino-alpha,alpha,alpha-trifluoro-p-creso 454-81-9
Price: US $9.80/KG
Min. Order: 1g
Purity: ≥99%
Supply Ability: 100kg
Release date: 2020-01-08

454-81-9, 2-amino-alpha,alpha,alpha-trifluoro-p-cresoRelated Search:

4-Hydroxy-3-nitrobenzotrifluoride 4-(4-CHLORO-3-METHYLPHENOXY)-3-NITROBENZOTRIFLUORIDE 4-METHOXY-3-NITROBENZOTRIFLUORIDE 2-Methoxy-5-(trifluoromethyl)aniline FLUORODIFEN 2-(4-METHYLPHENOXY)-5-(TRIFLUOROMETHYL)ANILINE 4-(4-METHOXYPHENOXY)-3-NITROBENZOTRIFLUORIDE 4-[4-(METHYLTHIO)PHENOXY]-3-NITROBENZOTRIFLUORIDE 2-AMINO-4'-CHLORO-4-TRIFLUOROMETHYL DIPHENYL ETHER 3-AMINO-4-(4-CHLORO-3,5-DIMETHYLPHENOXY)BENZOTRIFLUORIDE 2-BROMO-2'-NITRO-4'-(TRIFLUOROMETHYL)DIPHENYL ETHER 3-AMINO-4-(2-METHOXYPHENOXY)BENZOTRIFLUORIDE N1-[2-(4-CHLORO-3,5-DIMETHYLPHENOXY)-5-(TRIFLUOROMETHYL)PHENYL]-2,3,3-TRICHLOROACRYLAMIDE N-[2-(4-CHLORO-3,5-DIMETHYLPHENOXY)-5-(TRIFLUOROMETHYL)PHENYL]-N'-(1,2,2-TRICHLOROVINYL)UREA N1,N1-DIMETHYL-2-(4-CHLORO-3,5-DIMETHYLPHENOXY)-5-(TRIFLUOROMETHYL)ANILINE 1-CHLORO-5-(2,4-DICHLOROPHENOXY)-4-NITRO-2-(TRIFLUOROMETHYL)BENZENE N1-[2-(4-CYANOPHENOXY)-5-(TRIFLUOROMETHYL)PHENYL]-2-CHLOROACETAMIDE METHYL 3-[2-[(2-CHLOROACETYL)AMINO]-4-(TRIFLUOROMETHYL)PHENOXY]THIOPHENE-2-CARBOXYLATE

2-amino-alpha,alpha,alpha-trifluoro-p-creso

3-AMINO-4-HYDROXYBENZOTRIFLUORIDE

5-Amino-2-trifluoromethyl-phenol

2-amino-4-(trifluoromethyl)phenol

2-azanyl-4-(trifluoromethyl)phenol

2-Hydroxy-5-(trifluoromethyl)aniline, 2-Amino-4-(trifluoromethyl)phenol, 6-Hydroxy-alpha,alpha,alpha-trifluoro-m-toluidine

3-Amino-4-hydroxybenzotrifluoride 95%

T5394155

2-Hydroxy-5-(trifluoromethyl)aniline

4-(Trifluoromethyl)-2-aminophenol

Phenol, 2-amino-4-(trifluoromethyl)-

2-Amino-4-(trifluoromethyl)phenol, HCl

454-81-9

454-81-8