ChemicalBook > CAS DataBase List > 5-Methoxy-isobenzofuran-1,3-dione

5-Methoxy-isobenzofuran-1,3-dione

Product Name: 5-Methoxy-isobenzofuran-1,3-dione
CAS No.: 28281-76-7
Chemical Name: 5-Methoxy-isobenzofuran-1,3-dione
Synonyms: 5-Methoxy-isobenzofuran-1;5-Methoxy-2-benzofuran-1,3-dione;5-Methoxy-1,3-isobenzofurandione;5-Methoxy-isobenzofuran-1,3-dione;1,3-Isobenzofurandione, 5-methoxy-;METHYL N-(DIPHENYLMETHYLENE)-L-SERINATE;5-Methoxy-1,3-dihydro-2-benzofuran-1,3-dione
CBNumber: CB8875206
Molecular Formula: C9H6O4
Formula Weight: 178.14
MOL File: 28281-76-7.mol

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5-Methoxy-isobenzofuran-1,3-dione Property

Melting point:: 98-99 °C(Solv: acetic acid (64-19-7))
Boiling point:: 348.6±25.0 °C(Predicted)
Density: 1.407±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
Appearance: White to light yellow Solid

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Safety

HS Code: 2932990090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: M262975
Product name: 5-Methoxyisobenzofuran-1,3-dione
Packaging: 1g
Price: $250
Updated: 2021/12/16

SynQuest Laboratories

Product number: 2H26-1-0H
Product name: 5-Methoxyisobenzofuran-1,3-dione
Purity: 95%
Packaging: 250mg
Price: $256
Updated: 2021/12/16

Matrix Scientific

Product number: 072796
Product name: 5-Methoxyisobenzofuran-1,3-dione
Purity: 95+%
Packaging: 1g
Price: $462
Updated: 2021/12/16

AK Scientific

Product number: J95297
Product name: 5-Methoxy-isobenzofuran-1,3-dione
Packaging: 25g
Price: $540
Updated: 2021/12/16

SynQuest Laboratories

Product number: 2H26-1-0H
Product name: 5-Methoxyisobenzofuran-1,3-dione
Purity: 95%
Packaging: 1g
Price: $632
Updated: 2021/12/16

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5-Methoxy-isobenzofuran-1,3-dione Chemical Properties,Usage,Production

Uses

5-Methoxyisobenzofuran-1,3-dione is used as a reagent in the synthesis of basic ethers of 1,2-dihydropyrrolo[1,2-α]indole, 6H-isoindolo[2,1-α]indole, and 6H-benz[5,6]isoindolo[2,1-α]indole which display antiproliferative activity.

Synthesis

1885-13-8

28281-76-7

The general procedure for the synthesis of 5-methoxyisobenzofuran-1,3-dione using 4-methoxyphthalic acid as starting material was as follows: acetic anhydride (40 mL) was slowly added to a solution of anhydrous tetrahydrofuran (150 mL) containing 4-methoxyphthalic acid (30.8 g, 0.16 mol). The reaction mixture was refluxed with stirring for 4 hours. Upon completion of the reaction, the mixture was cooled to room temperature and the solvent was subsequently evaporated under reduced pressure to afford 4-methoxyphthalic anhydride (27.8 g, 99% yield) as an off-white solid. The structure of the product was confirmed by 1H NMR (DMSO-d6): δ 8.02 (1H, d), 7.59 (1H, d), 7.49 (1H, dd), 3.97 (3H, s). Mass spectrometry analysis showed the [M + H]+ peak at 179.

References

[1] Patent: WO2008/44029, 2008, A1. Location in patent: Page/Page column 204
[2] Patent: WO2008/44041, 2008, A1. Location in patent: Page/Page column 225-226
[3] Patent: WO2008/44045, 2008, A1. Location in patent: Page/Page column 277-278
[4] Patent: WO2008/44054, 2008, A2. Location in patent: Page/Page column 122
[5] Patent: US2010/152184, 2010, A1. Location in patent: Page/Page column 72; 73

5-Methoxy-isobenzofuran-1,3-dione Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 5-Methoxy-isobenzofuran-1,3-dione manufacturers

Career Henan Chemical Co

Product: 5-Methoxy-isobenzofuran-1,3-dione 28281-76-7
Price: US $9.80/KG
Min. Order: 1g
Purity: ≥99%
Supply Ability: 100kg
Release date: 2020-01-08

28281-76-7, 5-Methoxy-isobenzofuran-1,3-dioneRelated Search:

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5-Methoxy-1,3-dihydro-2-benzofuran-1,3-dione

METHYL N-(DIPHENYLMETHYLENE)-L-SERINATE

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5-Methoxy-isobenzofuran-1,3-dione

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28281-76-7