5-Methoxy-isobenzofuran-1,3-dione
- Product Name
- 5-Methoxy-isobenzofuran-1,3-dione
- CAS No.
- 28281-76-7
- Chemical Name
- 5-Methoxy-isobenzofuran-1,3-dione
- Synonyms
- 5-Methoxy-isobenzofuran-1;5-Methoxy-2-benzofuran-1,3-dione;5-Methoxy-1,3-isobenzofurandione;5-Methoxy-isobenzofuran-1,3-dione;1,3-Isobenzofurandione, 5-methoxy-;METHYL N-(DIPHENYLMETHYLENE)-L-SERINATE;5-Methoxy-1,3-dihydro-2-benzofuran-1,3-dione
- CBNumber
- CB8875206
- Molecular Formula
- C9H6O4
- Formula Weight
- 178.14
- MOL File
- 28281-76-7.mol
5-Methoxy-isobenzofuran-1,3-dione Property
- Melting point:
- 98-99 °C(Solv: acetic acid (64-19-7))
- Boiling point:
- 348.6±25.0 °C(Predicted)
- Density
- 1.407±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- Appearance
- White to light yellow Solid
Safety
- HS Code
- 2932990090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- M262975
- Product name
- 5-Methoxyisobenzofuran-1,3-dione
- Packaging
- 1g
- Price
- $250
- Updated
- 2021/12/16
- Product number
- 2H26-1-0H
- Product name
- 5-Methoxyisobenzofuran-1,3-dione
- Purity
- 95%
- Packaging
- 250mg
- Price
- $256
- Updated
- 2021/12/16
- Product number
- 072796
- Product name
- 5-Methoxyisobenzofuran-1,3-dione
- Purity
- 95+%
- Packaging
- 1g
- Price
- $462
- Updated
- 2021/12/16
- Product number
- J95297
- Product name
- 5-Methoxy-isobenzofuran-1,3-dione
- Packaging
- 25g
- Price
- $540
- Updated
- 2021/12/16
- Product number
- 2H26-1-0H
- Product name
- 5-Methoxyisobenzofuran-1,3-dione
- Purity
- 95%
- Packaging
- 1g
- Price
- $632
- Updated
- 2021/12/16
5-Methoxy-isobenzofuran-1,3-dione Chemical Properties,Usage,Production
Uses
5-Methoxyisobenzofuran-1,3-dione is used as a reagent in the synthesis of basic ethers of 1,2-dihydropyrrolo[1,2-α]indole, 6H-isoindolo[2,1-α]indole, and 6H-benz[5,6]isoindolo[2,1-α]indole which display antiproliferative activity.
Synthesis
1885-13-8
28281-76-7
The general procedure for the synthesis of 5-methoxyisobenzofuran-1,3-dione using 4-methoxyphthalic acid as starting material was as follows: acetic anhydride (40 mL) was slowly added to a solution of anhydrous tetrahydrofuran (150 mL) containing 4-methoxyphthalic acid (30.8 g, 0.16 mol). The reaction mixture was refluxed with stirring for 4 hours. Upon completion of the reaction, the mixture was cooled to room temperature and the solvent was subsequently evaporated under reduced pressure to afford 4-methoxyphthalic anhydride (27.8 g, 99% yield) as an off-white solid. The structure of the product was confirmed by 1H NMR (DMSO-d6): δ 8.02 (1H, d), 7.59 (1H, d), 7.49 (1H, dd), 3.97 (3H, s). Mass spectrometry analysis showed the [M + H]+ peak at 179.
References
[1] Patent: WO2008/44029, 2008, A1. Location in patent: Page/Page column 204
[2] Patent: WO2008/44041, 2008, A1. Location in patent: Page/Page column 225-226
[3] Patent: WO2008/44045, 2008, A1. Location in patent: Page/Page column 277-278
[4] Patent: WO2008/44054, 2008, A2. Location in patent: Page/Page column 122
[5] Patent: US2010/152184, 2010, A1. Location in patent: Page/Page column 72; 73
5-Methoxy-isobenzofuran-1,3-dione Preparation Products And Raw materials
Raw materials
Preparation Products
5-Methoxy-isobenzofuran-1,3-dione Suppliers
- Tel
- --
- Fax
- --
- info@chemsworth.com
- Country
- India
- ProdList
- 6700
- Advantage
- 30
- Tel
- --
- Fax
- --
- sales@ajchem.in
- Country
- India
- ProdList
- 6100
- Advantage
- 58
View Lastest Price from 5-Methoxy-isobenzofuran-1,3-dione manufacturers
- Product
- 5-Methoxy-isobenzofuran-1,3-dione 28281-76-7
- Price
- US $9.80/KG
- Min. Order
- 1g
- Purity
- ≥99%
- Supply Ability
- 100kg
- Release date
- 2020-01-08