(R)-2-Phenylpyrrolidine

Product Name: (R)-2-Phenylpyrrolidine
CAS No.: 56523-47-8
Chemical Name: (R)-2-Phenylpyrrolidine
Synonyms: 56523-47-8;(R)-2-Phenylpyrrolidine;(2R)-2-phenylpyrrolidine;Pyrrolidine, 2-phenyl-, (2R)-
CBNumber: CB8875433
Molecular Formula: C10H13N
Formula Weight: 147.22
MOL File: 56523-47-8.mol

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(R)-2-Phenylpyrrolidine Property

Boiling point:: 120 °C(Press: 6 Torr)
Density: 0.988±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
pka: 10.13±0.10(Predicted)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: P998488
Product name: (R)-2-Phenylpyrrolidine
Packaging: 100mg
Price: $265
Updated: 2021/12/16

AK Scientific

Product number: 9228AJ
Product name: (R)-2-Phenylpyrrolidine
Packaging: 250mg
Price: $278
Updated: 2021/12/16

Activate Scientific

Product number: AS43654
Product name: (R)-2-Phenylpyrrolidine
Purity: 95% ee
Packaging: 250mg
Price: $342
Updated: 2021/12/16

Activate Scientific

Product number: AS43654
Product name: (R)-2-Phenylpyrrolidine
Purity: 95% ee
Packaging: 100mg
Price: $171
Updated: 2021/12/16

AK Scientific

Product number: 9228AJ
Product name: (R)-2-Phenylpyrrolidine
Packaging: 1g
Price: $616
Updated: 2021/12/16

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(R)-2-Phenylpyrrolidine Chemical Properties,Usage,Production

Description

(R)-2-Phenylpyrrolidine is a boronic ester that can be administered orally. It has been shown to have nootropic and memory-enhancing activities in rats, but it does not have any known effects on kinase activities, amines, factor receptors, or synthetic activity.

Uses

(R)-2-Phenylpyrrolidine has also been shown to have prognostic value in cancer patients and can inhibit the growth of human cancer cells. This drug has been shown to bind to tropomyosin and growth factors with high affinity.

Definition

(R)-2-Phenylpyrrolidine is a novel class of selective pan-TRK inhibitors with efficacy in a KM12 rat tumor model. Since it was reported, this moiety has become a privileged TRK structure and was incorporated effectively in closely related scaffolds and on unrelated bicycle scaffolds. Its optimal shape complementarity to the TRK protein’s hydrophobic pocket available in the “DFG-in” conformation[1].

Origin

(R)-2-phenylpyrrolidine was first reported in 2008 by Ferrand S et al.

Properties and Applications

(R)-2-Phenylpyrrolidine is a yellow crystal,it is used as a pharmaceutical intermediate.

References

[1] Choi H, et al. (R)-2-Phenylpyrrolidine Substituted Imidazopyridazines: A New Class of Potent and Selective Pan-TRK Inhibitors. ACS Medicinal Chemistry Letters, 2015; 14: 562–567.

(R)-2-Phenylpyrrolidine Preparation Products And Raw materials

Raw materials

Preparation Products

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(R)-2-Phenylpyrrolidine Suppliers

China 75 India 2 United States 7 Global 85

Capot Chemical Co., Ltd

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Cool Pharm, Ltd

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View Lastest Price from (R)-2-Phenylpyrrolidine manufacturers

Career Henan Chemica Co

Product: (R)-2-Phenylpyrrolidine 56523-47-8
Price: US $0.37/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10kg/100kg
Release date: 2020-11-09

56523-47-8, (R)-2-PhenylpyrrolidineRelated Search:

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(R)-2-Phenylpyrrolidine

(2R)-2-phenylpyrrolidine

56523-47-8

Pyrrolidine, 2-phenyl-, (2R)-

56523-47-8

pharmaceutical intermediate

Chiral heterocyclic compounds