Bucumolol Property

Melting point:

>163° (dec.)

Boiling point:

490.7±45.0 °C(Predicted)

Density 

1.160±0.06 g/cm3(Predicted)

storage temp. 

Refrigerator

solubility 

Chloroform (Slightly), Methanol (Slightly)

form 

Solid

pka

13.81±0.20(Predicted)

color 

White to Off-White

Hazard and Precautionary Statements (GHS)

Bucumolol Chemical Properties,Usage,Production

Originator

Bucumarol,Sankyo,Japan,1982

Uses

Bucumolol is?an antihypertensive agent and a β-adrenoceptor blocker.

Definition

ChEBI: Bucumolol is a member of coumarins.

Manufacturing Process

A mixture of 3 g of 8-(2-hydroxy-3-chloropropoxy)-5-methyl coumarin, 4.3 g of t-butylamine and 60 ml of ethanol is heated at 100°C in a sealed tube for 15 hours. The reaction mixture is concentrated under reduced pressure to dryness. The residue is recrystallized from a mixture of ethanol and ether to give 2.1 g of the desired product melting at 226° to 228°C (with decomposition).
In practice it is usually used as hydrochloride.

Therapeutic Function

Beta-adrenergic blocker