2-[(4-chloro-3-nitrophenyl)sulphonyl]anthranilic acid
- Product Name
- 2-[(4-chloro-3-nitrophenyl)sulphonyl]anthranilic acid
- CAS No.
- 68003-38-3
- Chemical Name
- 2-[(4-chloro-3-nitrophenyl)sulphonyl]anthranilic acid
- Synonyms
- ABD7;ABD-7;ABD 7;Einecs 268-121-3;CTPI-2, 10 mM in DMSO;SLC25A1 inhibitor CTPI-2;2-(4-Chloro-3-nitrophenylsulfonamido)benzoic Acid;2-(4'-Chloro-3'-nitrobenzenesulfonamido)benzoic acid;2-[(4-chloro-3-nitrophenyl)sulphonyl]anthranilic acid;Benzoic acid, 2-(((4-chloro-3-nitrophenyl)sulfonyl)amino)-
- CBNumber
- CB8884338
- Molecular Formula
- C13H9ClN2O6S
- Formula Weight
- 356.74
- MOL File
- 68003-38-3.mol
2-[(4-chloro-3-nitrophenyl)sulphonyl]anthranilic acid Property
- Boiling point:
- 564.8±60.0 °C(Predicted)
- Density
- 1.660±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO:125 mg/mL(350.40 mM)
- form
- A solid
- pka
- 3.19±0.36(Predicted)
- color
- Off-white to light yellow
- EPA Substance Registry System
- Benzoic acid, 2-[[(4-chloro-3-nitrophenyl)sulfonyl]amino]- (68003-38-3)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H312Harmful in contact with skin
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- SML3650
- Product name
- CTPI-2
- Purity
- ≥98% (HPLC)
- Packaging
- 25MG
- Price
- $81.2
- Updated
- 2025/07/31
- Product number
- SML3650
- Product name
- CTPI-2
- Purity
- ≥98% (HPLC)
- Packaging
- 100mg
- Price
- $328
- Updated
- 2025/07/31
- Product number
- HCH0057276
- Product name
- 2-(4-CHLORO-3-NITROBENZENESULFONYLAMINO)BENZOIC ACID
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $648.81
- Updated
- 2021/12/16
- Product number
- HCH0057276
- Product name
- 2-(4-CHLORO-3-NITROBENZENESULFONYLAMINO)BENZOIC ACID
- Purity
- 95.00%
- Packaging
- 2.5G
- Price
- $852.21
- Updated
- 2021/12/16
- Product number
- 3988BA
- Product name
- Benzoicacid,2-[[(4-chloro-3-nitrophenyl)sulfonyl]amino]-
- Packaging
- 2.5g
- Price
- $864
- Updated
- 2021/12/16
2-[(4-chloro-3-nitrophenyl)sulphonyl]anthranilic acid Chemical Properties,Usage,Production
Uses
CTPI-2 is a third-generation mitochondrial citrate carrier SLC25A1 inhibitor with a KD of 3.5 μM. CTPI-2 inhibits glycolysis, PPARγ, and its downstream target the glucose transporter GLUT4. CTPI-2 halts salient alterations of NASH reverting steatosis, preventing the evolution to steatohepatitis, reducing inflammatory macrophage infiltration in the liver and adipose tissue, and starkly mitigating obesity induced by a high-fat diet. Antitumor activity[1][2].
Biological Activity
CTPI-2 is a selective mitochondrial citrate transporter (SLC25A1) inhibitor th at displays H1299 anti-proliferation activity in a SLC25A1-dependent manner (IC50 <10 μM). When compared with CTPI-1, CTPI-2 exhibits 20-fold higher target affinity (hSLC25A1 KD = 3.5 μM vs. 63.6 μM, respectively) and is ~1000-fold more potent against H1299 sphere-forming capacity. CTPI-2 inhibits mitochondrial respiration and formation of patient NSCLC tumors-derived CSCs spheres in cultures (10-50 μM), as well as suppresses the growth of patent-derived NSCLC exnografts in mice in vivo (28 mg/kg q.o.d. i.p.).
in vivo
CTPI-2 is a unique regulator of glycolysis that limits the metabolic plasticity of cancer stem cells (CSCs). CTPI-2 (26 mg/kg; i.p.) inhibits tumor growth in in vivo models of non-small cell lung cancer (NSCLC)[1].
CTPI-2 (50 mg/kg; i.p.; alternate days for 12 weeks) completely averts weight gain in the prevention study and leads to significant weight loss in the reversion study[2].
CTPI-2 prevents steatohepatitis and normalizes glucose tolerance. CTPI-2 lowers the levels of circulating IL-6 while increasing anti-inflammatory IL-4 and IL-10 and also reduced the monocyte chemoattractant protein-1 and monokine-induced by interferon-γ that attract neutrophils and monocytes. CTPI-2 regulates the citrate pool, the lipogenic and the gluconeogenic pathways[2].
| Animal Model: | C57BL/6J mice (HFD-fed mice)[2] |
| Dosage: | 50 mg/kg |
| Administration: | Alternate days via the intraperitoneal route for 12 weeks |
| Result: | Completely averted weight gain in the prevention study and led to significant weight loss in the reversion study. |
References
[1] Tan M, et al. Inhibition of the mitochondrial citrate carrier, Slc25a1, reverts steatosis, glucose intolerance, and inflammation in preclinical models of NAFLD/NASH. Cell Death Differ. 2020;27(7):2143-2157. DOI:10.1038/s41418-020-0491-6
[2] Fernandez HR, et al. The mitochondrial citrate carrier, SLC25A1, drives stemness and therapy resistance in non-small cell lung cancer. Cell Death Differ. 2018;25(7):1239-1258. DOI:10.1038/s41418-018-0101-z
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