etomidoline

Product Name: etomidoline
CAS No.: 21590-92-1
Chemical Name: etomidoline
Synonyms: Nonspa;K 2680;Smedolin;Amidoline;etomidoline;Phthalimidine, 2-ethyl-3-(β-piperidino-p-phenetidino)- (8CI);2-Ethyl-2,3-dihydro-3-[4-(2-piperidinoethoxy)anilino]-1H-isoindol-1-one;2-Ethyl-2,3-dihydro-3-[[4-[2-(1-piperidinyl)ethoxy]phenyl]amino]-1H-isoindol-1-one;1H-Isoindol-1-one, 2-ethyl-2,3-dihydro-3-[[4-[2-(1-piperidinyl)ethoxy]phenyl]amino]-
CBNumber: CB8896360
Molecular Formula: C23H29N3O2
Formula Weight: 379.5
MOL File: 21590-92-1.mol

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etomidoline Property

Melting point:: 106-107°
Boiling point:: 507.34°C (rough estimate)
Density: 1.1315 (rough estimate)
refractive index: 1.6500 (estimate)
pka: 8.75±0.10(Predicted)

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Safety

Toxicity: LD50 in mice (mg/kg): 176 orally; 44.8 i.v. (Giraldi, Mariotti, 1971)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: API0011397
Product name: ETOMIDOLINE
Purity: 95.00%
Packaging: 5MG
Price: $499.42
Updated: 2021/12/16

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etomidoline Chemical Properties,Usage,Production

Originator

Smedolin,Yamanouchi,Japan,1976

Definition

ChEBI: Etomidoline is an organic molecular entity.

Manufacturing Process

31.3 g of 1-oxo-3-(aminophenyl-p-ethoxypiperidino)-isoindoline (0.0892 mol) are dissolved in 500 ml of anhydrous N,N-dimethylformamide. To this solution 5.75 g of NaH (0.105 mol) and 7.24 ml of CH2CH2I (0.0945 mol) are added and the resulted mixture is heated at 70°C for 1 hour, and then poured into an excess of water. 1-oxo-2-ethyl-3-(aminophenyl-p-ethoxypiperidino)- isoindoline (MP 106°C to 107°C) is obtained by crystallization with ligroin.
1-oxo-2-ethyl-3-(iminophenyl-p-ethoxypiperidino)-isoindoline (MP 103°C to 104°C) is obtained as a byproduct with the above compound. This latter compound was reduced to produce 1-oxo-2-ethyl-3-(aminophenyl-p-ethoxypiperidino)-isoindoline.

Therapeutic Function

Muscle relaxant

etomidoline Preparation Products And Raw materials

Raw materials

Preparation Products

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etomidoline Suppliers

China 2 United States 2 Global 4

TargetMol Chemicals Inc.

Tel: 15002134094
Email: marketing@targetmol.cn
Country: China
ProdList: 19707
Advantage: 58

TargetMol Chemicals Inc.

Tel: +8613564774135
Email: zijue.cai@tsbiochem.com
Country: United States
ProdList: 19885
Advantage: 58

TargetMol Chemicals Inc.

Tel
Email: support@targetmol.com
Country: United States
ProdList: 38632
Advantage: 58

21590-92-1, etomidolineRelated Search:

4-[2-(DIMETHYLAMINO)ETHOXY]ANILINE 97 4-(2-piperidinoethoxy)aniline omidoline 4-(2-(DIETHYLAMINO)ETHOXY)ANILINE, 97 etomidoline

etomidoline

1H-Isoindol-1-one, 2-ethyl-2,3-dihydro-3-[[4-[2-(1-piperidinyl)ethoxy]phenyl]amino]-

Amidoline

K 2680

Nonspa

Phthalimidine, 2-ethyl-3-(β-piperidino-p-phenetidino)- (8CI)

Smedolin

2-Ethyl-2,3-dihydro-3-[[4-[2-(1-piperidinyl)ethoxy]phenyl]amino]-1H-isoindol-1-one

2-Ethyl-2,3-dihydro-3-[4-(2-piperidinoethoxy)anilino]-1H-isoindol-1-one

21590-92-1