etomidoline Property

Melting point:

106-107°

Boiling point:

507.34°C (rough estimate)

Density 

1.1315 (rough estimate)

refractive index 

1.6500 (estimate)

pka

8.75±0.10(Predicted)

Safety

Toxicity

LD50 in mice (mg/kg): 176 orally; 44.8 i.v. (Giraldi, Mariotti, 1971)

Hazard and Precautionary Statements (GHS)

etomidoline Chemical Properties,Usage,Production

Originator

Smedolin,Yamanouchi,Japan,1976

Definition

ChEBI: Etomidoline is an organic molecular entity.

Manufacturing Process

31.3 g of 1-oxo-3-(aminophenyl-p-ethoxypiperidino)-isoindoline (0.0892 mol) are dissolved in 500 ml of anhydrous N,N-dimethylformamide. To this solution 5.75 g of NaH (0.105 mol) and 7.24 ml of CH2CH2I (0.0945 mol) are added and the resulted mixture is heated at 70°C for 1 hour, and then poured into an excess of water. 1-oxo-2-ethyl-3-(aminophenyl-p-ethoxypiperidino)- isoindoline (MP 106°C to 107°C) is obtained by crystallization with ligroin.
1-oxo-2-ethyl-3-(iminophenyl-p-ethoxypiperidino)-isoindoline (MP 103°C to 104°C) is obtained as a byproduct with the above compound. This latter compound was reduced to produce 1-oxo-2-ethyl-3-(aminophenyl-p-ethoxypiperidino)-isoindoline.

Therapeutic Function

Muscle relaxant