pheneticillin
- Product Name
- pheneticillin
- CAS No.
- 147-55-7
- Chemical Name
- pheneticillin
- Synonyms
- Penorale;Alfacilin;Synthepen;NSC 117548;Phenoxy PC;Feneticillin;pheneticillin;Phenethecillin;Phenoxyethylpenicillin;pheneticillin USP/EP/BP
- CBNumber
- CB8897291
- Molecular Formula
- C17H20N2O5S
- Formula Weight
- 364.42
- MOL File
- 147-55-7.mol
pheneticillin Property
- Boiling point:
- 673.9±55.0 °C(Predicted)
- Density
- 1.41±0.1 g/cm3(Predicted)
- pka
- 2.44±0.50(Predicted)
N-Bromosuccinimide Price
- Product number
- API0024890
- Product name
- PHENETHICILLIN
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $502.47
- Updated
- 2021/12/16
pheneticillin Chemical Properties,Usage,Production
Originator
Syncillin, Bristol, US ,1959
Uses
Phenethicillin is a penicillin antibiotic medication.
Definition
ChEBI: A penicillin in which the substituent at position 6 of the penam ring is a 2-phenoxypropanamido group.
Manufacturing Process
Triethylamine (1.5 ml) was added to a cold solution (10°C) of αphenoxypropionic acid (1.66 g, 0.01 mol) in 15 ml of pure dioxane, with stirring and cooling to 5°C to 10°C while isobutyl chloroformate (1.36 g, 0.01 mol) in 5 ml of dioxane was added dropwise. Then the mixture was stirred for ten minutes at 5°C to 8°C. A solution of 6-amino-penicillanic acid (2.16 g, 0.01 mol) in 15 ml of water and 2 ml of triethylamine was then added dropwise while the temperature was maintained below 10°C. The resulting mixture was stirred in the cold for 15 minutes then at room temperature for 30 minutes, diluted with 30 ml of cold water and extracted with ether which was discarded. The cold aqueous solution was then covered with 75 ml of ether and acidified to pH 2 with 5 N H2SO4. After shaking, the ether layer containing the product 6-(α-phenoxypropionamido)penicillanic acid, was dried for ten minutes over anhydrous sodium sulfate and filtered. Addition of 6 ml of dry n-butanol containing 0.373 g/ml of potassium 2-ethylhexanoate precipitated the potassium salt of the product as a colorless oil which crystallized on stirring and scratching and was collected, dried in vacuo and found to weigh 2.75 g, to melt at 217°C to 219°C.
brand name
Chemipen (Bristol-Myers Squibb); Syncillin (Bristol-Myers Squibb) [Name previously used: Phenethicillin.].
Therapeutic Function
Antibacterial
pheneticillin Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from pheneticillin manufacturers
- Product
- Phenethicillin 147-55-7
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20T
- Release date
- 2020-05-11
- Product
- pheneticillin 147-55-7
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.9%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-06-25