(±)-1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide
- Product Name
- (±)-1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide
- CAS No.
- 38396-39-3
- Chemical Name
- (±)-1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide
- Synonyms
- Bupivacaina;Ah 250;Bucain;Bupivan;Rac-Bupivacaine;Bupivacaine Free Base;Bupivacaine (SKY 0402);Bupivacaine Base (IHS);(R,S)-Bupivqacaine hydrochloride;BUPIVACAINE FREE BASEBUPIVACAINE FREE BASE
- CBNumber
- CB8897837
- Molecular Formula
- C18H28N2O
- Formula Weight
- 288.43
- MOL File
- 38396-39-3.mol
(±)-1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide Property
- Melting point:
- 106-110℃
- Boiling point:
- 423.4±45.0 °C(Predicted)
- Density
- 1.032±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO:25.0(Max Conc. mg/mL);86.68(Max Conc. mM)
DMF:30.0(Max Conc. mg/mL);104.01(Max Conc. mM)
Ethanol:30.0(Max Conc. mg/mL);104.01(Max Conc. mM)
Ethanol:PBS (pH 7.2) (1:1):0.5(Max Conc. mg/mL);1.73(Max Conc. mM) - form
- Cyrstalline powder
- pka
- 14.85±0.70(Predicted)
- Water Solubility
- Soluble in water, ethanol, chloroform (slightly ), and acetone (slightly ).
- EPA Substance Registry System
- 2-Piperidinecarboxamide, 1-butyl-N-(2,6-dimethylphenyl)- (38396-39-3)
Safety
- TSCA
- Yes
- HazardClass
- 6.1
- Hazardous Substances Data
- 38396-39-3(Hazardous Substances Data)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H300Fatal if swallowed
H310Fatal in contact with skin
H330Fatal if inhaled
- Precautionary statements
-
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P320Specific treatment is urgent (see … on this label).
P330Rinse mouth.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- J62742
- Product name
- Bupivacaine
- Packaging
- 1g
- Price
- $155.65
- Updated
- 2024/03/01
- Product number
- J62742
- Product name
- Bupivacaine
- Packaging
- 5g
- Price
- $262.65
- Updated
- 2024/03/01
- Product number
- 16618
- Product name
- Bupivacaine
- Purity
- ≥98%
- Packaging
- 1g
- Price
- $50
- Updated
- 2024/03/01
- Product number
- 16618
- Product name
- Bupivacaine
- Purity
- ≥98%
- Packaging
- 5g
- Price
- $68
- Updated
- 2024/03/01
- Product number
- J62742
- Product name
- Bupivacaine
- Packaging
- 25g
- Price
- $1158
- Updated
- 2024/03/01
(±)-1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide Chemical Properties,Usage,Production
Description
Bupivacaine is a sodium channel blocker and local anesthetic. It inhibits sodium currents in rat dorsal horn neurons in a concentration-dependent manner and inhibits synaptic transmission in rat sympathetic ganglia, increasing the firing threshold when used at a concentration of 200 nM. Bupivacaine (10 μM) blocks cardiac sodium channels in a use-dependent manner and inhibits respiration in cardiac cell mitochondria when palmitoyl-carnitine or acetyl-carnitine are used as substrates (IC50s = 0.78 and 0.37 mM, respectively). It also reduces thermal hyperplasia in a rat model of sciatic ligation injury when 0.6 ml of a 0.5% solution is administered into the perinerve space, and the duration of this effect is extended by co-administration of the NMDA receptor antagonist MK-801 . Formulations containing bupivacaine have been used as local anesthetics for surgery, oral surgery, and dental procedures and for anesthetic purposes in research studies using animals.
Uses
Bupivacaine acts as a potent and long-acting local anesthetic agent in vivo. At 100 μM, it has been reported to inhibit the uptake of dopamine in striatal synaptosomes by 47%.
Definition
ChEBI: A piperidinecarboxamide obtained by formal condensation of the carboxy group of N-butylpipecolic acid with the amino group of 2,6-dimethylaniline.
(±)-1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide Preparation Products And Raw materials
Raw materials
Preparation Products
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