2-(4-fluorophenyl)propionic acid
- Product Name
- 2-(4-fluorophenyl)propionic acid
- CAS No.
- 75908-73-5
- Chemical Name
- 2-(4-fluorophenyl)propionic acid
- Synonyms
- 2-(4-Fluorophenyl)propanoic acid;2-(4-fluorophenyl)propionic acid;4-Fluoro-α-methylbenzeneacetic acid;4-Fluoro-alpha-methylphenylaceticacid;(+/-)-2-(4-flurophenyl)propanoic acid;Benzeneacetic acid,4-fluoro-a-methyl-;Benzeneacetic acid, 4-fluoro-α-methyl-;4-Fluoro-alpha-methylphenylacetic acid,98%
- CBNumber
- CB8900991
- Molecular Formula
- C9H9FO2
- Formula Weight
- 168.16
- MOL File
- 75908-73-5.mol
2-(4-fluorophenyl)propionic acid Property
- Boiling point:
- 258.8±15.0 °C(Predicted)
- Density
- 1?+-.0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- form
- solid
- pka
- 4.31±0.10(Predicted)
- color
- Off-white
Safety
- RIDADR
- 2811
- HazardClass
- 6.1
- PackingGroup
- Ⅲ
- HS Code
- 2918199890
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
N-Bromosuccinimide Price
- Product number
- S450359
- Product name
- 4-FLUORO-ALPHA-METHYLPHENYLACETIC ACID
- Purity
- Aldrich<sup>CPR</sup>
- Packaging
- 1 unit
- Price
- $113
- Updated
- 2025/07/31
- Product number
- S450359
- Product name
- 4-FLUORO-ALPHA-METHYLPHENYLACETIC ACID
- Purity
- AldrichCPR
- Packaging
- 250MG
- Price
- $110
- Updated
- 2024/03/01
- Product number
- B435040
- Product name
- 2-(4-Fluorophenyl)propanoicAcid
- Packaging
- 500mg
- Price
- $130
- Updated
- 2021/12/16
- Product number
- 077631
- Product name
- 2-(4-Fluorophenyl)propanoicacid
- Purity
- 95+%
- Packaging
- 1g
- Price
- $60
- Updated
- 2021/12/16
- Product number
- W8302
- Product name
- 2-(4-Fluorophenyl)propanoicacid
- Packaging
- 1g
- Price
- $131
- Updated
- 2021/12/16
2-(4-fluorophenyl)propionic acid Chemical Properties,Usage,Production
Synthesis
50415-71-9
75908-73-5
The general procedure for the synthesis of 2-(4-fluorophenyl)propionic acid from the compound (CAS: 50415-71-9) was as follows: under stirring conditions, racemic methyl 2-(4-thieno-phenyl)propionate (18.9 g) was dissolved in ethanol (200 mL) and an aqueous solution of potassium hydroxide (35 g) (200 mL) was slowly added. The reaction mixture was stirred continuously at 0 °C for 4 hours. Upon completion of the reaction, the pH was adjusted to 5 with 4.0 M hydrochloric acid, followed by extraction of the reaction mixture with ethyl acetate. The organic phase was separated and the solvent was removed by distillation under reduced pressure to give 15.64 g of 2-(4-fluorophenyl)propionic acid as a crude product. The crude product could be used directly in the subsequent reaction without further purification. The structure of the product was confirmed by 1H-NMR (300 MHz, DMSO-d6): δ [ppm] = 1.31 (d, 3H), 3.66 (q, 1H), 7.05-7.15 (m, 2H), 7.24-7.33 (m, 2H), 12.30 (s, 1H).
References
[1] Organic letters, 2002, vol. 4, # 3, p. 371 - 373
[2] Journal of Organic Chemistry, 2003, vol. 68, # 19, p. 7234 - 7242
[3] Patent: WO2010/31183, 2010, A1. Location in patent: Page/Page column 18
[4] Patent: WO2013/87579, 2013, A1. Location in patent: Page/Page column 134; 135
[5] Patent: WO2014/9219, 2014, A1. Location in patent: Page/Page column 107; 108
2-(4-fluorophenyl)propionic acid Preparation Products And Raw materials
Raw materials
Preparation Products
2-(4-fluorophenyl)propionic acid Suppliers
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- Country
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View Lastest Price from 2-(4-fluorophenyl)propionic acid manufacturers
- Product
- 2-(4-fluorophenyl)propionic acid 75908-73-5
- Price
- US $2.00/KG
- Min. Order
- 1KG
- Purity
- 98%MIN
- Supply Ability
- ASK
- Release date
- 2019-12-25