ChemicalBook > CAS DataBase List > 2-Pyridinecarboxylic acid, 2-(2-pyridinyl)hydrazide
2-Pyridinecarboxylic acid, 2-(2-pyridinyl)hydrazide
- Product Name
- 2-Pyridinecarboxylic acid, 2-(2-pyridinyl)hydrazide
- CAS No.
- 53995-62-3
- Chemical Name
- 2-Pyridinecarboxylic acid, 2-(2-pyridinyl)hydrazide
- Synonyms
- PFI-90;PFI-90, 10 mM in DMSO;N'-(Pyridin-2-yl)picolinohydrazide;N'-pyridin-2-ylpyridine-2-carbohydrazide;N'-(Pyridin-2-yl)pyridine-2-carbohydrazide;2-Pyridinecarboxylic acid, 2-(2-pyridinyl)hydrazide;antitumor,Inhibitor,PFI 90,differentiation,PAX3-FOXO1,demethylase,PFI-90,apoptosis,histone,Histone Demethylase,myogenic,PFI90,inhibit
- CBNumber
- CB89028245
- Molecular Formula
- C11H10N4O
- Formula Weight
- 214.22
- MOL File
- 53995-62-3.mol
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2-Pyridinecarboxylic acid, 2-(2-pyridinyl)hydrazide Property
- Melting point:
- 128-131 °C
- Boiling point:
- 359.4±17.0 °C(Predicted)
- Density
- 1.309±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO: 2mg/mL, clear
- form
- Solid
- pka
- 10.14±0.23(Predicted)
- color
- Light yellow to yellow
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2-Pyridinecarboxylic acid, 2-(2-pyridinyl)hydrazide Chemical Properties,Usage,Production
Uses
PFI-90 is a selective inhibitor of histone demethylase (KDM3B) that inhibits PAX3-FOXO1 action. PFI-90 induces apoptosis and myogenic differentiation, resulting in the cell death increased. PFI-90 has the potential for the antitumor activity. (patent WO2021101929A1).
Biological Activity
PFI-90 is a selective inhibitor of histone demethylase (KDM3B) that inhibits PAX3-FOXO1 action. PFI-90 induces apoptosis and myogenic differentiation, resulting in the cell death increased. PFI-90 has the potential for the antitumor activity. (patent WO2021101929A1). PFI-90 shows dose response in RH4, RH30, OSA-CL and TC-32 cells, with IC50s of 812, 3200, 1895 and 1113 nM, respectively[1]. PFI-90 (3 μμ; 24 hours) increases apoptosis in RH4 and SCMC cells[1].
IC 50
KDM3
References
[1]. KHAN, Javed, et al. Inhibitors of histone demethylases (pfi-63 and pfi-90) for the treatment of cancer and for the inhibition of histone demethylase in cells. WO2021101929A1.
2-Pyridinecarboxylic acid, 2-(2-pyridinyl)hydrazide Preparation Products And Raw materials
Raw materials
Preparation Products
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