ChemicalBook > CAS DataBase List > 8,8'-[carbonylbis[imino-3,1-phenylenecarbonylimino(4-methyl-3,1-phenylene)carbonylimino]]bisnaphthalene-1,3,5-trisulphonic acid
8,8'-[carbonylbis[imino-3,1-phenylenecarbonylimino(4-methyl-3,1-phenylene)carbonylimino]]bisnaphthalene-1,3,5-trisulphonic acid
- Product Name
- 8,8'-[carbonylbis[imino-3,1-phenylenecarbonylimino(4-methyl-3,1-phenylene)carbonylimino]]bisnaphthalene-1,3,5-trisulphonic acid
- CAS No.
- 145-63-1
- Chemical Name
- 8,8'-[carbonylbis[imino-3,1-phenylenecarbonylimino(4-methyl-3,1-phenylene)carbonylimino]]bisnaphthalene-1,3,5-trisulphonic acid
- Synonyms
- Naganil;Fourneau;Suramine;Naphuride;Farma 939;Aids000067;Aids-000067;129-46-4(Hexasodium salt);8,8-[carbonylbis[imino-3,1-phenylenecarbonylimino(4-methyl-3,1-phenylene)carbonylimino]]bisnaphthalene-1,3,5-trisulphonic acid;8,8'-[Carbonylbis[imino-3,1-phenylenecarbonylimino(4-methyl-3,1-phenylene)carbonyl-imino]]bis-1,3,5-naphthalenetrisulfonic acid
- CBNumber
- CB8906847
- Molecular Formula
- C51H40N6O23S6
- Formula Weight
- 1297.28
- MOL File
- 145-63-1.mol
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8,8'-[carbonylbis[imino-3,1-phenylenecarbonylimino(4-methyl-3,1-phenylene)carbonylimino]]bisnaphthalene-1,3,5-trisulphonic acid Property
- Melting point:
- 128 °C(Solv: ethyl ether (60-29-7))
- Density
- 1.2629 (rough estimate)
- refractive index
- 1.7770 (estimate)
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- pka
- -1.35±0.40(Predicted)
- color
- Pinkish-white, hygroscopic powder
- EPA Substance Registry System
- Suramin (145-63-1)
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Safety
- Toxicity
- LD50 intravenous in mouse: 620mg/kg
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N-Bromosuccinimide Price
American Custom Chemicals Corporation
- Product number
- API0004298
- Product name
- SURAMIN
- Purity
- 95.00%
- Packaging
- 50MG
- Price
- $692.73
- Updated
- 2021/12/16
American Custom Chemicals Corporation
- Product number
- API0004298
- Product name
- SURAMIN
- Purity
- 95.00%
- Packaging
- 250MG
- Price
- $1042.6
- Updated
- 2021/12/16
Chemtos
- Product number
- S-6954
- Product name
- Suramind12sodium
- Packaging
- 10mg
- Price
- $1990
- Updated
- 2021/12/16
Crysdot
- Product number
- CD31003423
- Product name
- Suramin
- Purity
- 98+%
- Packaging
- 50mg
- Price
- $54
- Updated
- 2021/12/16
CSNpharm
- Product number
- CSN17880
- Product name
- Suramin
- Packaging
- 10mg
- Price
- $56
- Updated
- 2021/12/16
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8,8'-[carbonylbis[imino-3,1-phenylenecarbonylimino(4-methyl-3,1-phenylene)carbonylimino]]bisnaphthalene-1,3,5-trisulphonic acid Chemical Properties,Usage,Production
Definition
ChEBI: Suramin is a member of the class of phenylureas that is urea in which each of the amino groups has been substituted by a 3-({2-methyl-5-[(4,6,8-trisulfo-1-naphthyl)carbamoyl]phenyl}carbamoyl)phenyl group. An activator of both the rabbit skeletal muscle RyR1 and sheep cardiac RyR2 isoform ryanodine receptor channels, it has been used for the treatment of human African trypanosomiasis for over 100 years. It has a role as a ryanodine receptor agonist, a GABA-gated chloride channel antagonist, a GABA antagonist, an apoptosis inhibitor, an antineoplastic agent, an angiogenesis inhibitor, a purinergic receptor P2 antagonist, an EC 2.7.11.13 (protein kinase C) inhibitor, an antinematodal drug and a trypanocidal drug. It is a member of phenylureas, a secondary carboxamide and a naphthalenesulfonic acid. It is functionally related to a naphthalene-1,3,5-trisulfonic acid. It is a conjugate acid of a suramin(6-).
Safety Profile
Moderately toxic by intravenousroute. Human systemic effects by intravenous route: eyeeffects. An experimental teratogen. Other experimentalreproductive effects. When heated to decomposition itemits very toxic fumes of SOx and NOx.
8,8'-[carbonylbis[imino-3,1-phenylenecarbonylimino(4-methyl-3,1-phenylene)carbonylimino]]bisnaphthalene-1,3,5-trisulphonic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 8,8'-[carbonylbis[imino-3,1-phenylenecarbonylimino(4-methyl-3,1-phenylene)carbonylimino]]bisnaphthalene-1,3,5-trisulphonic acid manufacturers
Zhuozhou Wenxi import and Export Co., Ltd
- Product
- Suramin 145-63-1
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10
Zhuozhou Wenxi import and Export Co., Ltd
- Product
- Suramin 145-63-1
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-09