ChemicalBook > CAS DataBase List > 9-fluoro-11beta,17-dihydroxy-16alpha-methylpregna-1,4-diene-3,20-dione 21-(9Z,12Z)-octadeca-9,12-dienoate

9-fluoro-11beta,17-dihydroxy-16alpha-methylpregna-1,4-diene-3,20-dione 21-(9Z,12Z)-octadeca-9,12-dienoate

Product Name
9-fluoro-11beta,17-dihydroxy-16alpha-methylpregna-1,4-diene-3,20-dione 21-(9Z,12Z)-octadeca-9,12-dienoate
CAS No.
39026-39-6
Chemical Name
9-fluoro-11beta,17-dihydroxy-16alpha-methylpregna-1,4-diene-3,20-dione 21-(9Z,12Z)-octadeca-9,12-dienoate
Synonyms
DXM-21-linoleate;dexamethasone linoleate;Dexamethasone-21-linoleate;9-fluoro-11beta,17-dihydroxy-16alpha-methylpregna-1,4-diene-3,20-dione 21-(9Z,12Z)-octadeca-9,12-dienoate;(9Z,12Z)-9,12-Octadecadienoic acid 9-fluoro-11β,17-dihydroxy-16α-methyl-3,20-dioxopregna-1,4-dien-21-yl ester
CBNumber
CB8918521
Molecular Formula
C40H58FO6-
Formula Weight
653.8833232
MOL File
39026-39-6.mol
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation
Product number
API0019016
Product name
DEXAMETHASONE-21-LINOLATE
Purity
95.00%
Packaging
5MG
Price
$498.31
Updated
2021/12/16
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9-fluoro-11beta,17-dihydroxy-16alpha-methylpregna-1,4-diene-3,20-dione 21-(9Z,12Z)-octadeca-9,12-dienoate Chemical Properties,Usage,Production

Originator

Topolyn ,I.S.F.,Italy,1979

Manufacturing Process

To a stirred solution of 9α-fluoro-11β,17,21-trihydroxy-16α-methyl-pregna1,4-diene-3,20-dione (10g, 25.5 mmol) in 20 ml pyridine and 12 ml acetone at -10°C, a cold solution of methanesulfonyl chloride (3 ml, 38.5 mmol) in 8 ml acetone was added dropwise. The addition was completed within about 3 hours and the mixture was then left standing in the cold for a further 1? hours after which 200 ml cold water were added. The resulting precipitate was separated by filtration and washed with water to give 11.5 g (96% of theoretical yield) of dexamethasone 21-mesylate, melting point 208°C to 210°C (decomposition).
The dexamethasone 21-mesylate (11.5 g, 24.5 mmol) prepared as described was added in a nitrogen atmosphere to a stirred slurry of potassium octadecacis-9, cis-12-dienoate (7.81 g, 24.5 mmol) in 70 ml DMF. After stirring for 1? hours at 50°C and evaporating the solvent in vacuo at the same temperature, the residue was washed by slurrying it into water and was then redissolved in methylene chloride, dried and the solvent evaporated. The residue was purified by chromatography on an inactivated (10% water) silica gel column (470 g) by using an ethyl acetate/hexane mixture (7:3) to give a very good yield of an oily product.

Therapeutic Function

Topical antiinflammatory

9-fluoro-11beta,17-dihydroxy-16alpha-methylpregna-1,4-diene-3,20-dione 21-(9Z,12Z)-octadeca-9,12-dienoate Preparation Products And Raw materials

Raw materials

Preparation Products

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9-fluoro-11beta,17-dihydroxy-16alpha-methylpregna-1,4-diene-3,20-dione 21-(9Z,12Z)-octadeca-9,12-dienoate Suppliers

Hangzhou MolCore BioPharmatech Co.,Ltd.
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+86-057181025280; +8617767106207
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0571-85806285
Email
sales@molcore.com
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China
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39026-39-6, 9-fluoro-11beta,17-dihydroxy-16alpha-methylpregna-1,4-diene-3,20-dione 21-(9Z,12Z)-octadeca-9,12-dienoateRelated Search:


  • 9-fluoro-11beta,17-dihydroxy-16alpha-methylpregna-1,4-diene-3,20-dione 21-(9Z,12Z)-octadeca-9,12-dienoate
  • Dexamethasone-21-linoleate
  • DXM-21-linoleate
  • dexamethasone linoleate
  • (9Z,12Z)-9,12-Octadecadienoic acid 9-fluoro-11β,17-dihydroxy-16α-methyl-3,20-dioxopregna-1,4-dien-21-yl ester
  • 39026-39-6