3-chloro-4-nitrophenol
- Product Name
- 3-chloro-4-nitrophenol
- CAS No.
- 491-11-2
- Chemical Name
- 3-chloro-4-nitrophenol
- Synonyms
- 3-Chlor-4-nitrophenol;Lenvatinib Impurity 44;Phenol, 3-chloro-4-nitro-;2-Chloro-4-hydroxynitrobenzene;3-chloro-4-nitrophenol CAS NO.491-11-2
- CBNumber
- CB8934842
- Molecular Formula
- C6H4ClNO3
- Formula Weight
- 173.55
- MOL File
- 491-11-2.mol
3-chloro-4-nitrophenol Property
- Melting point:
- 120-121℃
- Boiling point:
- 330.5±27.0 °C(Predicted)
- Density
- 1.554
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 6.32±0.10(Predicted)
- color
- Pale Yellow to Light Beige
- EPA Substance Registry System
- Phenol, 3-chloro-4-nitro- (491-11-2)
Safety
- HS Code
- 2908990000
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- C350275
- Product name
- 3-Chloro-4-nitrophenol
- Packaging
- 1g
- Price
- $85
- Updated
- 2021/12/16
- Product number
- Y9204
- Product name
- 3-Chloro-4-nitrophenol
- Packaging
- 1g
- Price
- $52
- Updated
- 2021/12/16
- Product number
- 131695
- Product name
- 3-Chloro-4-nitrophenol
- Purity
- 97%
- Packaging
- 1g
- Price
- $95
- Updated
- 2021/12/16
- Product number
- FC140090
- Product name
- 3-Chloro-4-nitrophenol
- Packaging
- 1g
- Price
- $100
- Updated
- 2021/12/16
- Product number
- FC140090
- Product name
- 3-Chloro-4-nitrophenol
- Packaging
- 2g
- Price
- $160
- Updated
- 2021/12/16
3-chloro-4-nitrophenol Chemical Properties,Usage,Production
Uses
3-Chloro-4-nitrophenol was used as a reactant in the synthetic preparation of highly potent BTK and JAK3 dual inhibitors and it may also have antifungal activity.
Synthesis
108-43-0
491-11-2
GENERAL METHOD: A suspension of 3-chlorophenol (18.5 mmol, 1.0 eq.) and Cu(NO3)2-3H2O (27.7 mmol, 1.5 eq.) in THF was formed by magnetic stirring or refluxing for several hours at 60 °C. The reaction was carried out under reduced pressure and the solvent was extracted with ethyl acetate (3 x 30 mL). Upon completion of the reaction, the solvent was removed under reduced pressure and the mixture was subsequently extracted with ethyl acetate (3 × 30 mL). The organic phases were combined, washed with saturated saline (5 mL), dried over anhydrous magnesium sulfate and concentrated under reduced pressure. The crude product was purified by column chromatography to afford the target compound 3-chloro-4-nitrophenol in 67-90% yield.
References
[1] Journal of Chemical Sciences, 2011, vol. 123, # 1, p. 63 - 67
[2] Arkivoc, 2014, vol. 2014, # 5, p. 64 - 71
[3] Research on Chemical Intermediates, 2018, vol. 44, # 10, p. 6023 - 6038
[4] International Journal of Chemical Kinetics, 2017, vol. 49, # 8, p. 622 - 632
[5] Helvetica Chimica Acta, 1963, vol. 46, p. 727 - 741
3-chloro-4-nitrophenol Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3-chloro-4-nitrophenol manufacturers
- Product
- 3-Chloro-4-nitrophenol 491-11-2
- Price
- US $2.00-5.00/KG
- Min. Order
- 0.1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons
- Release date
- 2025-07-09
- Product
- 3-chloro-4-nitrophenol 491-11-2
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 98.4%
- Supply Ability
- 100 tons
- Release date
- 2022-02-18
- Product
- 3-chloro-4-nitrophenol 491-11-2
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2019-07-12