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(9R)-6'-methoxycinchonan-9-ol

Product Name
(9R)-6'-methoxycinchonan-9-ol
CAS No.
572-59-8
Chemical Name
(9R)-6'-methoxycinchonan-9-ol
Synonyms
(9R)-;Epiquindine;Epiquinidine;9-Epiquinidine;(9R)-6'-methoxycinchonan-9-ol;(8R,9R)-6'-Methoxycinchonan-9-ol;Cinchonan-9-ol, 6'-methoxy-, (9R)-;(R)-(6-methoxy-4-quinolyl)-[(2R,4S,5R)-5-vinylquinuclidin-2-yl]methanol;(R)-[(4S,5R,7R)-5-ethenyl-1-azabicyclo[2.2.2]octan-7-yl]-(6-methoxyquinolin-4-yl)methanol
CBNumber
CB8939382
Molecular Formula
C20H24N2O2
Formula Weight
324.42
MOL File
572-59-8.mol
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(9R)-6'-methoxycinchonan-9-ol Property

Melting point:
111-113°
alpha 
D25 +107.8° (c = 1.02 in ethanol)
Boiling point:
462.75°C (rough estimate)
Density 
1.1294 (rough estimate)
refractive index 
1.5700 (estimate)
storage temp. 
2-8°C
form 
Solid-Liquid Mixture
pka
12.80±0.20(Predicted)
color 
White to off-white
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Safety

Hazard Codes 
Xn
Risk Statements 
22-42/43
Safety Statements 
22-36/37-45
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H302Harmful if swallowed

H317May cause an allergic skin reaction

H334May cause allergy or asthma symptoms or breathing difficulties if inhaled

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P342+P311IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

TRC
Product number
Q685005
Product name
9-epi-Quinidine
Packaging
100mg
Price
$155
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
PXT0002529
Product name
EPIQUINIDINE
Purity
95.00%
Packaging
5MG
Price
$500.05
Updated
2021/12/16
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(9R)-6'-methoxycinchonan-9-ol Chemical Properties,Usage,Production

Description

This alkaloid is stereoisomeric with epiQuinine and occurs in 'Quinoidine', the mixture of amorphous bases left after extraction of the four primary alkaloids of Cinchona bark. It crystallizes in colourless leaflets from Et20 and is fluorescent in dilute H2S04, It is dextrorotatory with [α]19D + 102.4° (c 0.8648, EtOH) and furnishes a dihydrochloride, m.p. 195-6°C (dec.); [α]20D + 45.5° (c 0.8012, EtOH); a hydrobromide, m.p. 240°C; thiocyanate, m.p. 193°C; [α]20D + 44.5° (H20) and the dibenzoyl-(+)-tartrate, m.p. 167°C; [α]201D + 3.7° (c 0.8068, EtOH-CHCI 3 ). Catalytic hydrogenation with Pd gives the dihydro derivative, m.p. 122°C; [α]22D + 73.1° (c 0.766, EtOH).

Uses

The 9-epimer of Quinidine (Q685000). Antimalarial.

References

Thron, Dirscherl., Annalen, 521,48 (1935)

(9R)-6'-methoxycinchonan-9-ol Preparation Products And Raw materials

Raw materials

Preparation Products

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(9R)-6'-methoxycinchonan-9-ol Suppliers

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572-59-8, (9R)-6'-methoxycinchonan-9-ol Related Search:

Quinine

  • Epiquindine
  • (9R)-6'-methoxycinchonan-9-ol
  • (8R,9R)-6'-Methoxycinchonan-9-ol
  • 9-Epiquinidine
  • Epiquinidine
  • (R)-(6-methoxy-4-quinolyl)-[(2R,4S,5R)-5-vinylquinuclidin-2-yl]methanol
  • (R)-[(4S,5R,7R)-5-ethenyl-1-azabicyclo[2.2.2]octan-7-yl]-(6-methoxyquinolin-4-yl)methanol
  • (9R)-
  • Cinchonan-9-ol, 6'-methoxy-, (9R)-
  • 572-59-8
  • Chiral Reagents
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Pharmaceuticals