4-[(2-(2-Aminoethoxy)ethyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione HCl

Product Name: 4-[(2-(2-Aminoethoxy)ethyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione HCl
CAS No.: 2154342-56-8
Chemical Name: 4-[(2-(2-Aminoethoxy)ethyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione HCl
Synonyms: 3-dione HCl;Poma-PEG2-NH2;Pomalidomide 4'-PEG1-amine;Thalidomide-NH-PEG1-NH2 TFA;Thalidomide-NH-PEG1-NH2 HCl;Pomalidomide-PEG1-C2-amine HCl;6-dioxopiperidin-3-yl)isoindoline-1;Thalidomide-NH-PEG1-NH2 hydrochloride;4-[(2-(2-Aminoethoxy)ethyl)amino]-2-(2;Pomalidomide 4'-PEG1-amine hydrochloride
CBNumber: CB89402036
Molecular Formula: C17H21ClN4O5
Formula Weight: 396.83
MOL File: 2154342-56-8.mol

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4-[(2-(2-Aminoethoxy)ethyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione HCl Property

storage temp.: 2-8°C
form: Solid
color: Light yellow to yellow
InChI: 1S/C17H20N4O5.ClH/c18-6-8-26-9-7-19-11-3-1-2-10-14(11)17(25)21(16(10)24)12-4-5-13(22)20-15(12)23;/h1-3,12,19H,4-9,18H2,(H,20,22,23);1H
InChIKey: LQYLHZFKGOZTOH-UHFFFAOYSA-N
SMILES: Cl.O=C1NC(=O)C(N2C(=O)C=3C=CC=C(NCCOCCN)C3C2=O)CC1

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Safety

WGK Germany: WGK 3
Storage Class: 6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects
Hazard Classifications: Repr. 1B

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P308+P313IF exposed or concerned: Get medical advice/attention.

P405Store locked up.

P501Dispose of contents/container to..…

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4-[(2-(2-Aminoethoxy)ethyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione HCl Chemical Properties,Usage,Production

Uses

Thalidomide-NH-PEG1-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology[1].

Biological Activity

Pomalidomide 4'-PEG1-amine is a functionalized cereblon ligand for PROTAC research and development; incorporates an E3 ligase ligand plus a PEG1 linker with terminal amine ready for conjugation to a target protein ligand.

IC 50

Cereblon

storage

Store at -20°C

References

[1] Sato T, et al. Cereblon-Based Small-Molecule Compounds to Control Neural Stem Cell Proliferation in Regenerative Medicine.Front Cell Dev Biol. 2021;9:629326. Published 2021 Mar 11. DOI:10.3389/fcell.2021.629326
[2] Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985. DOI:10.7554/eLife.57277

4-[(2-(2-Aminoethoxy)ethyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione HCl Preparation Products And Raw materials

Raw materials

Preparation Products

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4-[(2-(2-Aminoethoxy)ethyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione HCl Suppliers

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View Lastest Price from 4-[(2-(2-Aminoethoxy)ethyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione HCl manufacturers

Xian confluore Biological Technology Co., Ltd.

Product: Pomalidomide-NH-PEG1-amine hydrochloride 2154342-56-8
Price: US $0.00/g
Min. Order: 1g
Purity: >99.00%
Supply Ability: 1g
Release date: 2024-04-01

2154342-56-8, 4-[(2-(2-Aminoethoxy)ethyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione HClRelated Search:

4-[(2-(2-Aminoethoxy)ethyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione HCl

Pomalidomide-NH-PEG1-amine hydrochloride

3-dione HCl

4-[(2-(2-Aminoethoxy)ethyl)amino]-2-(2

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Thalidomide-NH-PEG1-NH2 hydrochloride

Thalidomide-NH-PEG1-NH2 TFA

inhibit,Thalidomide-NH-PEG-1-NH2 hydrochloride,ThalidomideNHPEG1NH2 hydrochloride,Inhibitor,E3 Ligase Ligand-Linker Conjugates,Thalidomide NH PEG1 NH2 hydrochloride

Pomalidomide 4'-PEG1-amine hydrochloride

Pomalidomide 4'-PEG1-amine

Pomalidomide-PEG1-C2-amine HCl

Poma-PEG2-NH2

Thalidomide-NH-PEG1-NH2 HCl

4-[[2-(2-Aminoethoxy)ethyl]amino]-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione hydrochloride

1H-Isoindole-1,3(2H)-dione, 4-[[2-(2-aminoethoxy)ethyl]amino]-2-(2,6-dioxo-3-piperidinyl)-, hydrochloride (1:1)

2154342-56-8