ChemicalBook > CAS DataBase List > Garenoxacin

Garenoxacin

Product Name: Garenoxacin
CAS No.: 223652-90-2
Chemical Name: Garenoxacin
Synonyms: Garenoxacin mesylate [USAN];BMS284756 (Mesylate hydrate);Garenoxacin mesylate hydrate;Garenoxacin mesylate monohydrate;Garenoxacin mesylate hydrate, 10 mM in DMSO;Garenoxacin mesylate monohydrate >=98% (HPLC);1-cyclopropyl-8-(difluoromethoxy)-4-keto-7-[(1R)-1-methylisoindolin-5-yl]quinoline-3-carboxylic acid;1-cyclopropyl-8-(difluoromethoxy)-7-[(1R)-1-methyl-2,3-dihydro-1H-isoindol-5-yl]-4-oxoquinoline-3-carboxylicacid,methanesulfonicacid,hydrate;1-Cyclopropyl-8-(difluoromethoxy)-7-[(1R)-2,3-dihydro-1-methyl-1H-isoindol-5-yl]-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid methanesulfonate hydrate;(R)-1-cyclopropyl-8-(difluoromethoxy)-7-(1-methylisoindolin-5-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid compound with methanesulfonic acid (1:1) hydrate
CBNumber: CB8947028
Molecular Formula: C23H20F2N2O4.CH4O3S.H2O
Formula Weight: 540.53
MOL File: 223652-90-2.mol

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Garenoxacin Property

storage temp.: 2-8°C
solubility: DMSO:100.0(Max Conc. mg/mL);185.0(Max Conc. mM)
Water:12.5(Max Conc. mg/mL);23.13(Max Conc. mM)
form: powder
color: white to beige
Water Solubility: H2O: 10mg/mL, clear (warmed)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H373May cause damage to organs through prolonged or repeated exposure

H400Very toxic to aquatic life

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P273Avoid release to the environment.

P314Get medical advice/attention if you feel unwell.

P391Collect spillage. Hazardous to the aquatic environment

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1618
Product name: Garenoxacin mesylate monohydrate
Purity: ≥98% (HPLC)
Packaging: 10mg
Price: $111
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML1618
Product name: Garenoxacin mesylate monohydrate
Purity: ≥98% (HPLC)
Packaging: 50mg
Price: $447
Updated: 2025/07/31

American Custom Chemicals Corporation

Product number: API0013697
Product name: GARENOXACIN MESYLATE HYDRATE
Purity: 95.00%
Packaging: 1G
Price: $993.3
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0013697
Product name: GARENOXACIN MESYLATE HYDRATE
Purity: 95.00%
Packaging: 2G
Price: $1309
Updated: 2021/12/16

ChemScene

Product number: CS-4990
Product name: GarenoxacinMesylatehydrate
Purity: 99.78%
Packaging: 10mg
Price: $132
Updated: 2021/12/16

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Garenoxacin Chemical Properties,Usage,Production

Uses

Antibacterial agent.

Biological Activity

Garenoxacin is a broad spectrum fluoroquinolone antibiotic suitable for treatment of gram-positive and gram-negative bacterial infections. Garenoxacin has a low mutant prevention concentration and a narrow mutant selection window. Data shows th at garenoxacin has anti-inflammatory properties. It significantly alleviates LPS-induced IL-8 production through the negative regulation of the ERK1/2 pathway both in the human airway epithelial cell line A549 and the monocyte cell line THP-1.

in vivo

Garenoxacin (12.5-50 mg/kg; s.c.; once) is highly effective against the wild-type strain and mutants harboring a single mutation in a mouse pneumonia model with S. pneumoniainfection^[4].
Garenoxacin (10 and 30 mg/kg; p.o.; once) reduces the viable cell counts in the lungs and significantly prolongs survival on experimental secondary pneumococcal pneumonia caused by S. pneumoniae D-979 in BALB/c female mice^[5].

Animal Model:	Swiss mice with S. pneumonia infection^[4].
Dosage:	12.5, 25 and 50 mg/kg
Administration:	Subcutaneous injection, once
Result:	Significantly improved the survival rate.

IC 50

Quinolone; Gyrase: 1.25 μg/mL (IC₅₀); TOPO IV: 1.5-2.5 μg/mL (IC₅₀)

Garenoxacin Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Garenoxacin manufacturers

BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.

Product: Garenoxacin Mesylate Hydrate 223652-90-2
Price: US $0.00/g
Min. Order: 1g
Purity: More Than 99%
Supply Ability: 100kg/Month
Release date: 2024-11-15

Career Henan Chemical Co

Product: Garenoxacin 223652-90-2
Price: US $1000.00/KG
Min. Order: 25KG
Purity: 99%
Supply Ability: 10tons
Release date: 2018-07-26

223652-90-2, Garenoxacin Related Search:

Garethelin Intermediate 1 Garenoxacin Mesilate Hydrate iMpurity 2,3-Dihydro-(1R)-methyl-5-(tetrahydro-4H-1,3,6,2-dioxazaborocin-2-yl)-2-(triphenylmethyl)-1H-isoindole (1R)-5-bromo-2,3-dihydro-1-methyl-1H-Isoindole Garenoxacin Mesilate Hydrate impurity D Galesarin intermediate 3 1-PROPANONE, 1-[(1R)-5-BROMO-1,3-DIHYDRO-1-METHYL-2H-ISOINDOL-2-YL]-2,2-DIMETHYL- (R)-(1-methyl-2-tritylisoindolin-5-yl)boronic acid Galesarin intermediate 2 Garenoxacin GARENOXACIN MESYLATE

1-Cyclopropyl-8-(difluoromethoxy)-7-[(1R)-2,3-dihydro-1-methyl-1H-isoindol-5-yl]-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid methanesulfonate hydrate

Garenoxacin mesylate hydrate

Garenoxacin mesylate hydrate 1-Cyclopropyl-8-(difluoromethoxy)-7-[(1R)-2,3-dihydro-1-methyl-1H-isoindol-5-yl]-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid methanesulfonate hydrate

(R)-1-cyclopropyl-8-(difluoromethoxy)-7-(1-methylisoindolin-5-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid compound with methanesulfonic acid (1:1) hydrate

1-cyclopropyl-8-(difluoromethoxy)-4-keto-7-[(1R)-1-methylisoindolin-5-yl]quinoline-3-carboxylic acid

BMS284756 (Mesylate hydrate)

Garenoxacin mesylate [USAN]

Garenoxacin mesylate monohydrate >=98% (HPLC)

1-cyclopropyl-8-(difluoromethoxy)-7-[(1R)-1-methyl-2,3-dihydro-1H-isoindol-5-yl]-4-oxoquinoline-3-carboxylicacid,methanesulfonicacid,hydrate

Garenoxacin mesylate hydrate,DNA/RNA Synthesis,Topoisomerase,S. pneumonia,S. aureus,gyrase,Garenoxacin Mesylate,ureaplasmas,Inhibitor,BMS284756 Mesylate,topoisomerase IV,Swiss mice,inhibit,Bacterial,mycoplasmas,Antibiotic

Garenoxacin mesylate monohydrate

Garenoxacin mesylate hydrate, 10 mM in DMSO

223652-90-2

C24H26F2N2O8S

C23H20F2N2O4CH4O3SH2O