ChemicalBook > CAS DataBase List > Garenoxacin

Garenoxacin

Product Name
Garenoxacin
CAS No.
223652-90-2
Chemical Name
Garenoxacin
Synonyms
Garenoxacin mesylate [USAN];BMS284756 (Mesylate hydrate);Garenoxacin mesylate hydrate;Garenoxacin mesylate monohydrate;Garenoxacin mesylate hydrate, 10 mM in DMSO;Garenoxacin mesylate monohydrate >=98% (HPLC);1-cyclopropyl-8-(difluoromethoxy)-4-keto-7-[(1R)-1-methylisoindolin-5-yl]quinoline-3-carboxylic acid;1-cyclopropyl-8-(difluoromethoxy)-7-[(1R)-1-methyl-2,3-dihydro-1H-isoindol-5-yl]-4-oxoquinoline-3-carboxylicacid,methanesulfonicacid,hydrate;1-Cyclopropyl-8-(difluoromethoxy)-7-[(1R)-2,3-dihydro-1-methyl-1H-isoindol-5-yl]-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid methanesulfonate hydrate;(R)-1-cyclopropyl-8-(difluoromethoxy)-7-(1-methylisoindolin-5-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid compound with methanesulfonic acid (1:1) hydrate
CBNumber
CB8947028
Molecular Formula
C23H20F2N2O4.CH4O3S.H2O
Formula Weight
540.53
MOL File
223652-90-2.mol
More
Less

Garenoxacin Property

storage temp. 
2-8°C
solubility 
DMSO:100.0(Max Conc. mg/mL);185.0(Max Conc. mM)
Water:12.5(Max Conc. mg/mL);23.13(Max Conc. mM)
form 
powder
color 
white to beige
Water Solubility 
H2O: 10mg/mL, clear (warmed)
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H373May cause damage to organs through prolonged or repeated exposure

H400Very toxic to aquatic life

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P273Avoid release to the environment.

P314Get medical advice/attention if you feel unwell.

P391Collect spillage. Hazardous to the aquatic environment

P501Dispose of contents/container to..…

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML1618
Product name
Garenoxacin mesylate monohydrate
Purity
≥98% (HPLC)
Packaging
10mg
Price
$111
Updated
2025/07/31
Sigma-Aldrich
Product number
SML1618
Product name
Garenoxacin mesylate monohydrate
Purity
≥98% (HPLC)
Packaging
50mg
Price
$447
Updated
2025/07/31
AK Scientific
Product number
M525
Product name
Garenoxacinmesylatehydrate
Packaging
1mg
Price
$29
Updated
2021/12/16
ChemScene
Product number
CS-4990
Product name
GarenoxacinMesylatehydrate
Purity
99.78%
Packaging
5mg
Price
$96
Updated
2021/12/16
ChemScene
Product number
CS-4990
Product name
GarenoxacinMesylatehydrate
Purity
99.78%
Packaging
10mg
Price
$132
Updated
2021/12/16
More
Less

Garenoxacin Chemical Properties,Usage,Production

Uses

Antibacterial agent.

Biological Activity

Garenoxacin is a broad spectrum fluoroquinolone antibiotic suitable for treatment of gram-positive and gram-negative bacterial infections. Garenoxacin has a low mutant prevention concentration and a narrow mutant selection window. Data shows th at garenoxacin has anti-inflammatory properties. It significantly alleviates LPS-induced IL-8 production through the negative regulation of the ERK1/2 pathway both in the human airway epithelial cell line A549 and the monocyte cell line THP-1.

in vivo

Garenoxacin (12.5-50 mg/kg; s.c.; once) is highly effective against the wild-type strain and mutants harboring a single mutation in a mouse pneumonia model with S. pneumoniainfection[4].
Garenoxacin (10 and 30 mg/kg; p.o.; once) reduces the viable cell counts in the lungs and significantly prolongs survival on experimental secondary pneumococcal pneumonia caused by S. pneumoniae D-979 in BALB/c female mice[5].

Animal Model:Swiss mice with S. pneumonia infection[4].
Dosage:12.5, 25 and 50 mg/kg
Administration:Subcutaneous injection, once
Result:Significantly improved the survival rate.

IC 50

Quinolone; Gyrase: 1.25 μg/mL (IC50); TOPO IV: 1.5-2.5 μg/mL (IC50)

Garenoxacin Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

Garenoxacin Suppliers

China 63 India 1 South Korea 1 United Kingdom 1 United States 8 Global 74
Pharmaffiliates Analytics and Synthetics P. Ltd
Tel
--
Fax
--
Email
mktg@pharmaffiliates.com
Country
India
ProdList
6739
Advantage
58
More
Less

View Lastest Price from Garenoxacin manufacturers

BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.
Product
Garenoxacin Mesylate Hydrate 223652-90-2
Price
US $0.00/g
Min. Order
1g
Purity
More Than 99%
Supply Ability
100kg/Month
Release date
2024-11-15
Career Henan Chemical Co
Product
Garenoxacin 223652-90-2
Price
US $1000.00/KG
Min. Order
25KG
Purity
99%
Supply Ability
10tons
Release date
2018-07-26

223652-90-2, Garenoxacin Related Search:

Garethelin Intermediate 1 Garenoxacin Mesilate Hydrate iMpurity 2,3-Dihydro-(1R)-methyl-5-(tetrahydro-4H-1,3,6,2-dioxazaborocin-2-yl)-2-(triphenylmethyl)-1H-isoindole (1R)-5-bromo-2,3-dihydro-1-methyl-1H-Isoindole Garenoxacin Mesilate Hydrate impurity D Galesarin intermediate 3 1-PROPANONE, 1-[(1R)-5-BROMO-1,3-DIHYDRO-1-METHYL-2H-ISOINDOL-2-YL]-2,2-DIMETHYL- (R)-(1-methyl-2-tritylisoindolin-5-yl)boronic acid Galesarin intermediate 2 Garenoxacin GARENOXACIN MESYLATE

  • 1-Cyclopropyl-8-(difluoromethoxy)-7-[(1R)-2,3-dihydro-1-methyl-1H-isoindol-5-yl]-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid methanesulfonate hydrate
  • Garenoxacin mesylate hydrate
  • Garenoxacin mesylate hydrate 1-Cyclopropyl-8-(difluoromethoxy)-7-[(1R)-2,3-dihydro-1-methyl-1H-isoindol-5-yl]-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid methanesulfonate hydrate
  • (R)-1-cyclopropyl-8-(difluoromethoxy)-7-(1-methylisoindolin-5-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid compound with methanesulfonic acid (1:1) hydrate
  • 1-cyclopropyl-8-(difluoromethoxy)-4-keto-7-[(1R)-1-methylisoindolin-5-yl]quinoline-3-carboxylic acid
  • BMS284756 (Mesylate hydrate)
  • Garenoxacin mesylate [USAN]
  • Garenoxacin mesylate monohydrate >=98% (HPLC)
  • 1-cyclopropyl-8-(difluoromethoxy)-7-[(1R)-1-methyl-2,3-dihydro-1H-isoindol-5-yl]-4-oxoquinoline-3-carboxylicacid,methanesulfonicacid,hydrate
  • Garenoxacin mesylate hydrate,DNA/RNA Synthesis,Topoisomerase,S. pneumonia,S. aureus,gyrase,Garenoxacin Mesylate,ureaplasmas,Inhibitor,BMS284756 Mesylate,topoisomerase IV,Swiss mice,inhibit,Bacterial,mycoplasmas,Antibiotic
  • Garenoxacin mesylate monohydrate
  • Garenoxacin mesylate hydrate, 10 mM in DMSO
  • 223652-90-2
  • C24H26F2N2O8S
  • C23H20F2N2O4CH4O3SH2O