3-fluoro-4-methoxypropiophenone

Product Name: 3-fluoro-4-methoxypropiophenone
CAS No.: 586-22-1
Chemical Name: 3-fluoro-4-methoxypropiophenone
Synonyms: 1-(3-Fluoro-4-methoxyphenyl);3'-FLUORO-4'-METHOXYPROPIOPHENONE;1-(3-fluoro-4-methoxyphenyl)propan-1-one;1-Propanone, 1-(3-fluoro-4-Methoxyphenyl)-;1-(3-Fluoro-4-methoxyphenyl)propan-1-one, 2-Fluoro-4-propanoylanisole
CBNumber: CB8947194
Molecular Formula: C10H11FO2
Formula Weight: 182.19
MOL File: 586-22-1.mol

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3-fluoro-4-methoxypropiophenone Property

Melting point:: 83-85 °C
Boiling point:: 278.5±20.0 °C(Predicted)
Density: 1.099±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature

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Safety

HS Code: 2914409000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Matrix Scientific

Product number: 170758
Product name: 1-(3-Fluoro-4-methoxyphenyl)-1-propanone
Packaging: 1mg
Price: $90
Updated: 2021/12/16

Matrix Scientific

Product number: 170758
Product name: 1-(3-Fluoro-4-methoxyphenyl)-1-propanone
Packaging: 5mg
Price: $105
Updated: 2021/12/16

Matrix Scientific

Product number: 170758
Product name: 1-(3-Fluoro-4-methoxyphenyl)-1-propanone
Packaging: 10mg
Price: $146
Updated: 2021/12/16

Apolloscientific

Product number: PC9108
Product name: 3'-Fluoro-4'-methoxypropiophenone
Packaging: 1g
Price: $415
Updated: 2021/12/16

Rieke Metals

Product number: K0256211
Product name: 1-(3-Fluoro-4-methoxy-phenyl)-propan-1-one
Packaging: 1g
Price: $527
Updated: 2021/12/16

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3-fluoro-4-methoxypropiophenone Chemical Properties,Usage,Production

Preparation

Obtained by reaction of propionyl chloride or propionic anhydride with 2-fluoroanisole in the presence of aluminium chloride in carbon disulfide.

Synthesis

1649-96-3

586-22-1

To a stirred dichloromethane (CH2Cl2, 40 mL) solution of dimethyl sulfoxide (DMSO, 7.60 mL, 107 mmol) was slowly added a dichloromethane (CH2Cl2, 20 mL) solution of oxaloyl chloride ((COCl)2, 6.20 mL, 72.3 mmol) at -78 °C. After keeping stirring at -78 °C for 0.25 h, a dichloromethane (CH2Cl2, 40 mL) solution of α-ethyl-3-fluoro-4-methoxybenzenemethanol was slowly added, and stirring was continued for 0.5 h at -78 °C. Subsequently, triethylamine (Et3N, 18.0 mL, 129 mmol) was added at -78 °C and the reaction mixture was gradually warmed up to room temperature over a period of 1 hour. Upon completion of the reaction, the reaction was quenched with water and the mixture was extracted with ethyl acetate (EtOAc). The organic layer was washed sequentially with water and brine, dried over anhydrous sodium sulfate (Na2SO4) and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (eluent: n-hexane/ethyl acetate = 15:1) to afford 1-(3-fluoro-4-methoxyphenyl)propan-1-one (3.88 g, 21.3 mmol, 66% yield) as a white solid.1H NMR (400 MHz, CDCl3) δ: 1.22 (3H, t, J = 7.3 Hz), 2.94 (2H , q, J = 7.3 Hz), 3.96 (3H, s), 7.00 (1H, t, J = 8.6 Hz), 7.69-7.77 (2H, m).

References

[1] Patent: EP2168960, 2010, A1. Location in patent: Page/Page column 115
[2] Bioorganic and Medicinal Chemistry Letters, 2013, vol. 23, # 1, p. 375 - 381

3-fluoro-4-methoxypropiophenone Preparation Products And Raw materials

Raw materials

Preparation Products

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3-fluoro-4-methoxypropiophenone Suppliers

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586-22-1, 3-fluoro-4-methoxypropiophenone Related Search:

3-(3-FLUORO-4-METHOXYBENZOYL)PROPIONIC ACID 3-fluoro-4-methoxypropiophenone 3-FLUORO-4-METHOXYBENZOYLACETONITRILE 3',5'-DIFLUORO-4'-METHOXYPROPIOPHENONE SALOR-INT L353396-1EA 1-[2-(diethylamino)ethyl]-4-(3-fluoro-4-methoxybenzoyl)-3-hydroxy-5-(4-methoxyphenyl)-1,5-dihydro-2H-pyrrol-2-one 5-[4-(benzyloxy)phenyl]-4-(3-fluoro-4-methoxybenzoyl)-3-hydroxy-1-[3-(1H-imidazol-1-yl)propyl]-1,5-dihydro-2H-pyrrol-2-one SALOR-INT L428167-1EA 2-BROMO-1-(3-FLUORO-4-METHOXY-PHENYL)-2-PHENYL-ETHANONE SALOR-INT L431982-1EA SALOR-INT L432024-1EA SALOR-INT L428981-1EA 5-[4-(benzyloxy)-3-methoxyphenyl]-4-(3-fluoro-4-methoxybenzoyl)-3-hydroxy-1-(3-methoxypropyl)-1,5-dihydro-2H-pyrrol-2-one SALOR-INT L432008-1EA SALOR-INT L432016-1EA SALOR-INT L353361-1EA 3'-FLUORO-4'-METHOXY-2-PHENYLACETOPHENONE SALOR-INT L360074-1EA

1-Propanone, 1-(3-fluoro-4-Methoxyphenyl)-

1-(3-fluoro-4-methoxyphenyl)propan-1-one

1-(3-Fluoro-4-methoxyphenyl)

1-(3-Fluoro-4-methoxyphenyl)propan-1-one, 2-Fluoro-4-propanoylanisole

3'-FLUORO-4'-METHOXYPROPIOPHENONE

586-22-1

Adehydes, Acetals & Ketones

Anisoles, Alkyloxy Compounds & Phenylacetates

Fluorine Compounds