3-fluoro-4-methoxypropiophenone
- Product Name
- 3-fluoro-4-methoxypropiophenone
- CAS No.
- 586-22-1
- Chemical Name
- 3-fluoro-4-methoxypropiophenone
- Synonyms
- 1-(3-Fluoro-4-methoxyphenyl);3'-FLUORO-4'-METHOXYPROPIOPHENONE;1-(3-fluoro-4-methoxyphenyl)propan-1-one;1-Propanone, 1-(3-fluoro-4-Methoxyphenyl)-;1-(3-Fluoro-4-methoxyphenyl)propan-1-one, 2-Fluoro-4-propanoylanisole
- CBNumber
- CB8947194
- Molecular Formula
- C10H11FO2
- Formula Weight
- 182.19
- MOL File
- 586-22-1.mol
3-fluoro-4-methoxypropiophenone Property
- Melting point:
- 83-85 °C
- Boiling point:
- 278.5±20.0 °C(Predicted)
- Density
- 1.099±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
Safety
- HS Code
- 2914409000
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 170758
- Product name
- 1-(3-Fluoro-4-methoxyphenyl)-1-propanone
- Packaging
- 1mg
- Price
- $90
- Updated
- 2021/12/16
- Product number
- 170758
- Product name
- 1-(3-Fluoro-4-methoxyphenyl)-1-propanone
- Packaging
- 5mg
- Price
- $105
- Updated
- 2021/12/16
- Product number
- 170758
- Product name
- 1-(3-Fluoro-4-methoxyphenyl)-1-propanone
- Packaging
- 10mg
- Price
- $146
- Updated
- 2021/12/16
- Product number
- PC9108
- Product name
- 3'-Fluoro-4'-methoxypropiophenone
- Packaging
- 1g
- Price
- $415
- Updated
- 2021/12/16
- Product number
- K0256211
- Product name
- 1-(3-Fluoro-4-methoxy-phenyl)-propan-1-one
- Packaging
- 1g
- Price
- $527
- Updated
- 2021/12/16
3-fluoro-4-methoxypropiophenone Chemical Properties,Usage,Production
Preparation
Obtained by reaction of propionyl chloride or propionic anhydride with 2-fluoroanisole in the presence of aluminium chloride in carbon disulfide.
Synthesis
1649-96-3
586-22-1
To a stirred dichloromethane (CH2Cl2, 40 mL) solution of dimethyl sulfoxide (DMSO, 7.60 mL, 107 mmol) was slowly added a dichloromethane (CH2Cl2, 20 mL) solution of oxaloyl chloride ((COCl)2, 6.20 mL, 72.3 mmol) at -78 °C. After keeping stirring at -78 °C for 0.25 h, a dichloromethane (CH2Cl2, 40 mL) solution of α-ethyl-3-fluoro-4-methoxybenzenemethanol was slowly added, and stirring was continued for 0.5 h at -78 °C. Subsequently, triethylamine (Et3N, 18.0 mL, 129 mmol) was added at -78 °C and the reaction mixture was gradually warmed up to room temperature over a period of 1 hour. Upon completion of the reaction, the reaction was quenched with water and the mixture was extracted with ethyl acetate (EtOAc). The organic layer was washed sequentially with water and brine, dried over anhydrous sodium sulfate (Na2SO4) and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (eluent: n-hexane/ethyl acetate = 15:1) to afford 1-(3-fluoro-4-methoxyphenyl)propan-1-one (3.88 g, 21.3 mmol, 66% yield) as a white solid.1H NMR (400 MHz, CDCl3) δ: 1.22 (3H, t, J = 7.3 Hz), 2.94 (2H , q, J = 7.3 Hz), 3.96 (3H, s), 7.00 (1H, t, J = 8.6 Hz), 7.69-7.77 (2H, m).
References
[1] Patent: EP2168960, 2010, A1. Location in patent: Page/Page column 115
[2] Bioorganic and Medicinal Chemistry Letters, 2013, vol. 23, # 1, p. 375 - 381
3-fluoro-4-methoxypropiophenone Preparation Products And Raw materials
Raw materials
Preparation Products
3-fluoro-4-methoxypropiophenone Suppliers
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