ethyl-3-methyl-1H-pyrazole-4-carboxylate
- Product Name
- ethyl-3-methyl-1H-pyrazole-4-carboxylate
- CAS No.
- 85290-78-4
- Chemical Name
- ethyl-3-methyl-1H-pyrazole-4-carboxylate
- Synonyms
- NSC 19454;Ethyl 3-Methylpyrazole-4-carboxylate;3-methylpyrazole-4-ethyl formate;Ethyl5-methylpyrazole-4-carboxylate;Ethyl 3-methyl-1H-pyrazol-4-carboxylate;ethyl-3-methyl-1H-pyrazole-4-carboxylate;ETHYL 3-METHYL-2H-PYRAZOLE-4-CARBOXYLATE;3-Methyl-1H-pyrazol-4-carboxylic acid ethyl ester;3-Methyl-1H-pyrazole-4-carboxylic Acid Ethyl Ester
- CBNumber
- CB8969316
- Molecular Formula
- C7H10N2O2
- Formula Weight
- 154.17
- MOL File
- 85290-78-4.mol
ethyl-3-methyl-1H-pyrazole-4-carboxylate Property
- Melting point:
- 49-52°C
- Boiling point:
- 280.6±20.0 °C(Predicted)
- Density
- 1.171±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,2-8°C
- solubility
- soluble in Chloroform, Methanol
- pka
- 12.26±0.50(Predicted)
- form
- solid
- color
- Light yellow to yellow
- InChI
- InChI=1S/C7H10N2O2/c1-3-11-7(10)6-4-8-9-5(6)2/h4H,3H2,1-2H3,(H,8,9)
- InChIKey
- HHYVTIKYZUMDIL-UHFFFAOYSA-N
- SMILES
- N1C=C(C(OCC)=O)C(C)=N1
Safety
- WGK Germany
- 3
- HS Code
- 2933119000
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- 732583
- Product name
- Ethyl 3-methylpyrazole-4-carboxylate
- Packaging
- 250mg
- Price
- $56.2
- Updated
- 2023/06/20
- Product number
- E925115
- Product name
- Ethyl 3-methylpyrazole-4-carboxylate
- Packaging
- 2g
- Price
- $205
- Updated
- 2021/12/16
- Product number
- E925115
- Product name
- Ethyl 3-methylpyrazole-4-carboxylate
- Packaging
- 10g
- Price
- $690
- Updated
- 2021/12/16
- Product number
- 045202
- Product name
- Ethyl 5-methyl-1H-pyrazole-4-carboxylate
- Purity
- >95%
- Packaging
- 1g
- Price
- $38
- Updated
- 2021/12/16
- Product number
- OR300792
- Product name
- Ethyl5-methyl-1H-pyrazole-4-carboxylate
- Packaging
- 1g
- Price
- $38
- Updated
- 2021/12/16
ethyl-3-methyl-1H-pyrazole-4-carboxylate Chemical Properties,Usage,Production
Chemical Properties
Yellow Solid
Uses
Shows systemic antifungal activity accompanied by high levels of phytotoxicity.
Synthesis
141-97-9
4637-24-5
85290-78-4
[1255] To a solution of ethyl 3-oxobutyrate (20.0 g, 153.7 mmol) in tetrahydrofuran (THF, 150 mL) was added N,N-dimethylformamide dimethyl acetal (DMF-DMA, 19.2 g, 161.4 mmol). The reaction mixture was stirred at 70 °C for 2 hours. After completion of the reaction, the solvent was removed by concentration under reduced pressure to give the crude product. The crude product was dissolved in ethanol (EtOH, 150 mL) and hydrazine hydrate (NH2NH2-H2O, 9.2 g, 184.4 mmol) was added slowly and dropwise. The mixture was stirred at 80 °C for 16 hours. At the end of the reaction, the ethanol was removed by concentration under reduced pressure. The residue was diluted with brine (80 mL) and extracted with ethyl acetate (200 mL × 2). The organic layers were combined, dried with anhydrous magnesium sulfate (MgSO4), filtered and concentrated under reduced pressure to afford the target compound ethyl 3-methylpyrazole-4-carboxylate (257a, 21.0 g, 87.8% yield) as a pale green solid.1H NMR (CDCl3, 400 MHz): δ 7.96 (s, 1H), 4.29 (q, J = 7.2 Hz, 2H) 2.55 (s, 3H), 1.34 (t, J = 7.2 Hz, 3H).MS (ESI) m/z (M + H) + 154.8.
References
[1] Patent: WO2018/64119, 2018, A1. Location in patent: Paragraph 1255
[2] Patent: WO2016/25918, 2016, A1. Location in patent: Paragraph 105
ethyl-3-methyl-1H-pyrazole-4-carboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
ethyl-3-methyl-1H-pyrazole-4-carboxylate Suppliers
- Tel
- 022-59002498-8008; 15122574756
- info@fcmeditech.com
- Country
- China
- ProdList
- 68
- Advantage
- 58
- Tel
- 18210857532; 18210857532
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 96815
- Advantage
- 76
- Tel
- 86-027-67849912
- Fax
- 86-027-87531808
- sales@chemwish.com
- Country
- China
- ProdList
- 35896
- Advantage
- 56
- Tel
- 0573-85285100 18627885956
- Fax
- 0573-85285100
- isenchem@163.com
- Country
- China
- ProdList
- 9310
- Advantage
- 66
- Tel
- 021-50795510 4000665055
- Fax
- 021-50795055
- sales@accelachem.com
- Country
- China
- ProdList
- 11035
- Advantage
- 64
- Tel
- 10-61256048 13810278579
- Fax
- +86 10 61256049
- sales@zeroschem.com
- Country
- China
- ProdList
- 1370
- Advantage
- 59
- Tel
- 025-83697070
- Fax
- +86-25-83453306
- info@chemlin.com.cn
- Country
- China
- ProdList
- 15883
- Advantage
- 64
- Tel
- 021-50135380
- shchemsky@sina.com
- Country
- China
- ProdList
- 32321
- Advantage
- 50
- Tel
- 025-58395930
- Fax
- 025-5861-9182
- sales@acornpharma.com
- Country
- China
- ProdList
- 982
- Advantage
- 60
- Tel
- 021-61312847 13636370518
- Fax
- 021-55068248
- shyysw007@163.com
- Country
- China
- ProdList
- 4999
- Advantage
- 60
View Lastest Price from ethyl-3-methyl-1H-pyrazole-4-carboxylate manufacturers
- Product
- ethyl-3-methyl-1H-pyrazole-4-carboxylate 85290-78-4
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 150KG
- Release date
- 2019-07-09