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4-Fluoroisoquinoline

Product Name
4-Fluoroisoquinoline
CAS No.
394-67-2
Chemical Name
4-Fluoroisoquinoline
Synonyms
4-fluoroisoquinoline sulfate;4-FLUOROISOQUINOLINE;4-Floro isoquinoli11e;Isoquinoline, 4-fluoro-;4-Fluoroisoquinoline 95+%;4-Fluoroisoquinoline ISO 9001：2015 REACH
CBNumber
CB8971782
Molecular Formula
C9H6FN
Formula Weight
147.15
MOL File
394-67-2.mol
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4-Fluoroisoquinoline Property

Melting point:
34 °C
Boiling point:
240℃
Density 
1.216
refractive index 
1.5914
Flash point:
99℃
storage temp. 
2-8°C
form 
powder to lump
pka
3.45±0.10(Predicted)
color 
White to Light yellow
InChI
InChI=1S/C9H6FN/c10-9-6-11-5-7-3-1-2-4-8(7)9/h1-6H
InChIKey
VFFQGPWQVYUFLV-UHFFFAOYSA-N
SMILES
C1C2=C(C=CC=C2)C(F)=CN=1
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Safety

HS Code 
2933491090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

TCI Chemical
Product number
F1057
Product name
4-Fluoroisoquinoline
Packaging
250MG
Price
$155
Updated
2025/07/31
TRC
Product number
B435208
Product name
4-Fluoroisoquinoline
Packaging
500mg
Price
$65
Updated
2021/12/16
Apolloscientific
Product number
PC250003
Product name
4-Fluoroisoquinoline
Purity
95+%
Packaging
1g
Price
$66
Updated
2021/12/16
SynQuest Laboratories
Product number
3H32-3-7Q
Product name
4-Fluoroisoquinoline
Packaging
1g
Price
$106
Updated
2021/12/16
AK Scientific
Product number
Y5413
Product name
4-Fluoroisoquinoline
Packaging
1g
Price
$161
Updated
2021/12/16
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4-Fluoroisoquinoline Chemical Properties,Usage,Production

Uses

4-fluoroisoquinoline is a useful research chemical.

Synthesis

1532-97-4

394-67-2

General procedure for the synthesis of 4-fluoroisoquinoline from 4-bromoisoquinoline: A solution of 4-bromoisoquinoline (20 g, 96.6 mmol) dissolved in 144 mL of THF was added slowly and dropwise to a 760 mL THF solution containing n-butyllithium (133 mL, 332.5 mmol, 2.5 M in THF) at -65 °C. After the dropwise addition was completed, the reaction mixture was continued to be stirred at -65 °C for 30 min. Subsequently, a solution of N-fluorobenzenesulfonimide (66.68 g, 211.7 mmol) dissolved in 216 mL THF was added dropwise at the same temperature. After addition, the reaction was maintained at -65 °C for 1 hour. Upon completion of the reaction, the mixture was slowly warmed to room temperature and the reaction was quenched by the addition of 300 mL of saturated aqueous ammonium chloride. The reaction mixture was extracted with ethyl acetate (300 mL x 3), and the combined organic phases were washed with 300 mL of saturated brine, dried over anhydrous sodium sulfate, and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography (elution gradient: 0-100% ethyl acetate/petroleum ether) to afford 4-fluoroisoquinoline (8.5 g, red oil, yield: 60%).

References

[1] Journal of the American Chemical Society, 2014, vol. 136, # 10, p. 3792 - 3795
[2] Patent: US2017/37050, 2017, A1. Location in patent: Paragraph 0301; 0302
[3] Patent: US2007/179127, 2007, A1. Location in patent: Page/Page column 47-48
[4] Patent: US2009/48223, 2009, A1. Location in patent: Page/Page column 101
[5] Patent: US2010/93789, 2010, A1. Location in patent: Page/Page column 46

4-Fluoroisoquinoline Preparation Products And Raw materials

Raw materials

Preparation Products

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4-Fluoroisoquinoline Suppliers

Americas 1 China 130 Europe 3 India 7 Japan 1 United Kingdom 2 United States 6 Global 150
Aladdin Scientific
Tel
Email
tp@aladdinsci.com
Country
United States
ProdList
57505
Advantage
58
Aceschem Inc.
Tel
+1-817863-6948 +1-（817）863-6948
Email
sales@aceschem.com
Country
United States
ProdList
19632
Advantage
58
3B Scientific Corporation
Tel
--
Fax
--
Email
sales@3bsc.com
Country
United States
ProdList
6718
Advantage
47
Combi-Blocks Inc.
Tel
--
Fax
--
Email
sales@combi-blocks.com
Country
United States
ProdList
6618
Advantage
69
SynQuest Laboratories, Inc.
Tel
--
Fax
--
Email
info@synquestlabs.com
Country
United States
ProdList
6871
Advantage
62
Matrix Scientific
Tel
--
Fax
--
Email
sales@matrixscientific.com
Country
United States
ProdList
6632
Advantage
80
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View Lastest Price from 4-Fluoroisoquinoline manufacturers

Henan Aochuang Chemical Co.,Ltd.
Product
4-Fluoroisoquinoline 394-67-2
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-10-19
S&Y Biochem Co.,Ltd
Product
4-Fluoroisoquinoline 394-67-2
Price
US $1.00/kg
Min. Order
1kg
Purity
98
Supply Ability
100
Release date
2024-10-22
Shaanxi Dideu New Materials Co. Ltd
Product
4-Fluoroisoquinoline 394-67-2
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
10000KGS
Release date
2025-02-23

394-67-2, 4-FluoroisoquinolineRelated Search:

4-Fluoroisoquinoline 6-FLUOROISOQUINOLINE

  • 4-fluoroisoquinoline sulfate
  • Isoquinoline, 4-fluoro-
  • 4-Fluoroisoquinoline 95+%
  • 4-Fluoroisoquinoline ISO 9001：2015 REACH
  • 4-FLUOROISOQUINOLINE
  • 4-Floro isoquinoli11e
  • 394-67-2