BTO-1
- Product Name
- BTO-1
- CAS No.
- 40647-02-7
- Chemical Name
- BTO-1
- Synonyms
- BTO-1;Polo-like Kinase Inhibitor II, BTO-1;5-Cyano-7-nitro-2-benzothiazolecarboxamide-3-oxide;2-Benzothiazolecarboxamide, 5-cyano-7-nitro-, 3-oxide;Polo-like Kinase Inhibitor II, BTO-1 - CAS 40647-02-7 - Calbiochem
- CBNumber
- CB8972299
- Molecular Formula
- C9H4N4O4S
- Formula Weight
- 264.22
- MOL File
- 40647-02-7.mol
BTO-1 Property
- Boiling point:
- 553.0±60.0 °C(Predicted)
- Density
- 1.89±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- H2O: <2ML/mL
- form
- solid
- pka
- 14.67±0.30(Predicted)
- color
- tan
Safety
- Hazard Codes
- Xn
- Risk Statements
- 20/21/22-36/37/38
- Safety Statements
- 26-36/37
- WGK Germany
- 3
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H312Harmful in contact with skin
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B6311
- Product name
- BTO-1
- Purity
- ≥98% (HPLC), solid
- Packaging
- 5mg
- Price
- $188
- Updated
- 2024/03/01
- Product number
- 528283
- Product name
- Polo-like Kinase Inhibitor II, BTO-1
- Packaging
- 2mg
- Price
- $259
- Updated
- 2024/03/01
- Product number
- B6311
- Product name
- BTO-1
- Purity
- ≥98% (HPLC), solid
- Packaging
- 25mg
- Price
- $589
- Updated
- 2024/03/01
- Product number
- B694340
- Product name
- BTO-1
- Packaging
- 2mg
- Price
- $105
- Updated
- 2021/12/16
- Product number
- B694340
- Product name
- BTO-1
- Packaging
- 4mg
- Price
- $165
- Updated
- 2021/12/16
BTO-1 Chemical Properties,Usage,Production
Uses
BTO-1 is a benzothiazolo-N-oxide Plk1 inhibitor.
General Description
A cell-permeable benzothiazolo-N-oxide compound that targets the ATP-binding pocket of polo-like kinase and is shown to inhibit Plk1 kinase activity in cell-free kinase assays (IC50 = 8.0 μM) and suppress the phosphorylation of cellular Plk1 substrate Cdc25C in rat kangaroo kidney-derived PTK cells (75% inhibition at 6.3 μM). BTO-1 treatment of cultured cells results in mitosis defects consistent with loss-of-Plk1 phenotypes seen in Plk1 RNAi-treated U20S cells, including the appearance of monopolar spindles and the reduction of γ-tubulin at the centrosomes. Plk1 inhibition by BTO-1 in HeLa cells results in a blockage of Rho and Rho-GEF recruitment, which is essential for the assembly of a functional contractile ring.
Biochem/physiol Actions
BTO-1 is a polo-like kinase (Plk) inhibitor.
BTO-1 Preparation Products And Raw materials
Raw materials
Preparation Products
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