BTO-1

Product Name
BTO-1
CAS No.
40647-02-7
Chemical Name
BTO-1
Synonyms
BTO-1;Polo-like Kinase Inhibitor II, BTO-1;5-Cyano-7-nitro-2-benzothiazolecarboxamide-3-oxide;2-Benzothiazolecarboxamide, 5-cyano-7-nitro-, 3-oxide;Polo-like Kinase Inhibitor II, BTO-1 - CAS 40647-02-7 - Calbiochem
CBNumber
CB8972299
Molecular Formula
C9H4N4O4S
Formula Weight
264.22
MOL File
40647-02-7.mol
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BTO-1 Property

Boiling point:
553.0±60.0 °C(Predicted)
Density 
1.89±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
H2O: <2ML/mL
form 
solid
pka
14.67±0.30(Predicted)
color 
tan
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Safety

Hazard Codes 
Xn
Risk Statements 
20/21/22-36/37/38
Safety Statements 
26-36/37
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
B6311
Product name
BTO-1
Purity
≥98% (HPLC), solid
Packaging
5mg
Price
$188
Updated
2024/03/01
Sigma-Aldrich
Product number
528283
Product name
Polo-like Kinase Inhibitor II, BTO-1
Packaging
2mg
Price
$259
Updated
2024/03/01
Sigma-Aldrich
Product number
B6311
Product name
BTO-1
Purity
≥98% (HPLC), solid
Packaging
25mg
Price
$589
Updated
2024/03/01
TRC
Product number
B694340
Product name
BTO-1
Packaging
2mg
Price
$105
Updated
2021/12/16
TRC
Product number
B694340
Product name
BTO-1
Packaging
4mg
Price
$165
Updated
2021/12/16
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BTO-1 Chemical Properties,Usage,Production

Uses

BTO-1 is a benzothiazolo-N-oxide Plk1 inhibitor.

General Description

A cell-permeable benzothiazolo-N-oxide compound that targets the ATP-binding pocket of polo-like kinase and is shown to inhibit Plk1 kinase activity in cell-free kinase assays (IC50 = 8.0 μM) and suppress the phosphorylation of cellular Plk1 substrate Cdc25C in rat kangaroo kidney-derived PTK cells (75% inhibition at 6.3 μM). BTO-1 treatment of cultured cells results in mitosis defects consistent with loss-of-Plk1 phenotypes seen in Plk1 RNAi-treated U20S cells, including the appearance of monopolar spindles and the reduction of γ-tubulin at the centrosomes. Plk1 inhibition by BTO-1 in HeLa cells results in a blockage of Rho and Rho-GEF recruitment, which is essential for the assembly of a functional contractile ring.

Biochem/physiol Actions

BTO-1 is a polo-like kinase (Plk) inhibitor.

BTO-1 Preparation Products And Raw materials

Raw materials

Preparation Products

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BTO-1 Suppliers

China 15 India 1 Switzerland 1 United States 3 Global 20
Sigma-Aldrich
Tel
021-61415566 800-8193336
Email
orderCN@merckgroup.com
Country
China
ProdList
51456
Advantage
80
TargetMol Chemicals Inc.
Tel
4008200310
Email
marketing@tsbiochem.com
Country
China
ProdList
24647
Advantage
58
Shanghai Aladdin Biochemical Technology Co.,Ltd.
Tel
+86-18521732826
Email
market@aladdin-e.com
Country
China
ProdList
48461
Advantage
58
Aladdin Scientific
Tel
+1-+1(833)-552-7181
Email
sales@aladdinsci.com
Country
United States
ProdList
52925
Advantage
58

40647-02-7, BTO-1Related Search:


  • BTO-1
  • 5-Cyano-7-nitro-2-benzothiazolecarboxamide-3-oxide
  • Polo-like Kinase Inhibitor II, BTO-1
  • Polo-like Kinase Inhibitor II, BTO-1 - CAS 40647-02-7 - Calbiochem
  • 2-Benzothiazolecarboxamide, 5-cyano-7-nitro-, 3-oxide
  • 40647-02-7
  • C9H4N4O4S