ChemicalBook > CAS DataBase List > PTACH

PTACH

Product Name
PTACH
CAS No.
848354-66-5
Chemical Name
PTACH
Synonyms
NCH 51;NCH51, >98%;PTACH?, >98%;PTACH (NCH-51);HDAC Inhibitor XXII, NCH51;HDAC Inhibitor XXII, NCH51 - CAS 848354-66-5 - Calbiochem;Cpd 51, S-[6-(4-Phenyl-2-thiazolylcarbamoyl)hexyl] thioisobutyrate;S-(7-Oxo-7-((4-phenylthiazol-2-yl)amino)-heptyl) 2-methylpropanethioate;S-[7-oxo-7-[(4-phenyl-1,3-thiazol-2-yl)amino]heptyl] 2-methylpropanethioate;2-MethylpropanethioicacidS-[7-oxo-7-[(4-phenyl-2-thiazolyl)amino]heptyl]ester
CBNumber
CB8972794
Molecular Formula
C20H26N2O2S2
Formula Weight
390.56
MOL File
848354-66-5.mol
More
Less

PTACH Property

Melting point:
127-128 °C(Solv: hexane (110-54-3); ethyl acetate (141-78-6))
Density 
1.181±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO: soluble26mg/mL
form 
White powder
pka
9.52±0.50(Predicted)
color 
White to off-white
More
Less

Safety

Hazard Codes 
Xi
Risk Statements 
41
Safety Statements 
26-39
WGK Germany 
3
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H318Causes serious eye damage

H413May cause long lasting harmful effects to aquatic life

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
382185
Product name
HDAC Inhibitor XXII, NCH51
Packaging
2mg
Price
$140
Updated
2023/01/07
Sigma-Aldrich
Product number
P5874
Product name
PTACH
Purity
≥98% (HPLC), solid
Packaging
2mg
Price
$286
Updated
2022/05/15
Cayman Chemical
Product number
21234
Product name
NCH-51
Purity
≥98%
Packaging
1 mg
Price
$26
Updated
2024/03/01
Cayman Chemical
Product number
21234
Product name
NCH-51
Purity
≥98%
Packaging
5mg
Price
$96
Updated
2024/03/01
Cayman Chemical
Product number
21234
Product name
NCH-51
Purity
≥98%
Packaging
10mg
Price
$153
Updated
2024/03/01
More
Less

PTACH Chemical Properties,Usage,Production

Uses

NCH 51 is a Histone deacetylase inhibitor.

Definition

ChEBI: 2-methylpropanethioic acid S-[7-oxo-7-[(4-phenyl-2-thiazolyl)amino]heptyl] ester is an aromatic amide.

General Description

A cell-permeable S-isobutyryl prodrug that is processed intracellularly to form the potent HDAC inhibitor NCH-31 (IC50 = 48 and 170 nM, respectively, using partially purified HDAC1 or HeLa nuclear extract) that is predicted to exhibit a similar HADC binding mode as that of SAHA with its sulfhydryl replacing SAHA′s hydroxamate as the active-site zinc-targeting group. NCH-51 is shown to exhibit comparable antiproliferative (mean IC50 = 3.8 μM vs. 3.7 μM for SAHA; 48 h treatment) and apoptotic activity as SAHA against various cancer cell lines, but not PBMCs from 4 healthy individuals (IC50 >30 μM with either drug), and the antioxidant N-Acetyl-L-Cysteine (NAC; Cat. No. 106425) at 2 mM is reported to abolish the cell-growth inhibition caused by either 3 μM NCH-51 or SAHA in the Multiple Myeloma U266 cultures. Half-life in human plasma at 37 °C = 24 h.

Biological Activity

Histone deacetylase (HDAC) inhibitor. Inhibits growth of various cancer cells in vitro (EC 50 = 1.1-9.1 μ M).

Biochem/physiol Actions

HDAC inhibitor; more potent than the majority of HDAC inhibitors except for SAHA (gold standard).

References

[1]. suzuki t, hisakawa s, itoh y, et al. identification of a potent and stable antiproliferative agent by the prodrug formation of a thiolate histone deacetylase inhibitor. bioorg med chem lett, 2007, 17(6): 1558-1561.
[2]. suzuki t, nagano y, kouketsu a, et al. novel inhibitors of human histone deacetylases: design, synthesis, enzyme inhibition, and cancer cell growth inhibition of saha-based non-hydroxamates. j med chem, 2005, 48(4): 1019-1032.
[3]. sanda t, okamoto t, uchida y, et al. proteome analyses of the growth inhibitory effects of nch-51, a novel histone deacetylase inhibitor, on lymphoid malignant cells. leukemia, 2007, 21(11): 2344-2353.
[4]. victoriano af, imai k, togami h, et al. novel histone deacetylase inhibitor nch-51 activates latent hiv-1 gene expression. febs lett, 2011, 585(7): 1103-1111.

PTACH Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

PTACH Suppliers

EMMX Biotechnology LLC
Tel
888-539-0666
Fax
888-539-0666
Email
info@emmx.com
Country
United States
ProdList
8447
Advantage
60
Musechem
Tel
+1-800-259-7612
Fax
+1-800-259-7612
Email
info@musechem.com
Country
United States
ProdList
4660
Advantage
60
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
32161
Advantage
58
InvivoChem
Tel
+1-708-310-1919 +1-13798911105
Fax
708-557-7486
Email
sales@invivochem.cn
Country
United States
ProdList
6391
Advantage
58
Aladdin Scientific
Tel
+1-+1(833)-552-7181
Email
sales@aladdinsci.com
Country
United States
ProdList
57505
Advantage
58
TargetMol Chemicals Inc.
Tel
Email
support@targetmol.com
Country
United States
ProdList
38631
Advantage
58
ApexBio Technology
Tel
--
Fax
--
Email
sales@apexbt.com
Country
United States
ProdList
6251
Advantage
58
Cayman Chemical Company
Tel
--
Fax
--
Email
cayman@caymanchem.com
Country
United States
ProdList
6213
Advantage
81
United States Biological
Tel
--
Fax
--
Email
chemicals@usbio.net
Country
United States
ProdList
6214
Advantage
80
MedChemExpress
Tel
--
Fax
--
Email
sales@medchemexpress.com
Country
United States
ProdList
6398
Advantage
58
Riedel-de Haen AG
Tel
--
Fax
--
Country
United States
ProdList
6773
Advantage
87
Matrix Scientific
Tel
--
Fax
--
Email
sales@matrixscientific.com
Country
United States
ProdList
6632
Advantage
80

848354-66-5, PTACHRelated Search:


  • Cpd 51, S-[6-(4-Phenyl-2-thiazolylcarbamoyl)hexyl] thioisobutyrate
  • 2-MethylpropanethioicacidS-[7-oxo-7-[(4-phenyl-2-thiazolyl)amino]heptyl]ester
  • NCH 51
  • S-(7-Oxo-7-((4-phenylthiazol-2-yl)amino)-heptyl) 2-methylpropanethioate
  • PTACH (NCH-51)
  • HDAC Inhibitor XXII, NCH51
  • Propanethioic acid,2-methyl-, S-[7-oxo-7-[(4-phenyl-2-thiazolyl)amino]heptyl] ester
  • NCH51, >98%
  • PTACH?, >98%
  • HDAC Inhibitor XXII, NCH51 - CAS 848354-66-5 - Calbiochem
  • HIV-1,inhibit,NCH 51,PTACH,HIV,Inhibitor,Histone deacetylases,hyperacetylation,NCH51,Anti-cancer,p21WAF1/CIP1,Human immunodeficiency virus,HDAC,SAHA
  • S-[7-oxo-7-[(4-phenyl-1,3-thiazol-2-yl)amino]heptyl] 2-methylpropanethioate
  • 848354-66-5