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LY 294002

Product Name
LY 294002
CAS No.
934389-88-5
Chemical Name
LY 294002
Synonyms
LY 294002, HYDROCHLORIDE SALT;LY-294,002 hydrochloride【L9908】;LY 294002, Hydrochloride Salt, >99%;LY-294,002 hydrochloride, ≥98% (HPLC);LY-294002 hydrochloride, 10 mM in DMSO;2-Morpholin-4-yl-8-phenyl-4H-chromen-4-one HCl;2-morpholino-8-phenyl-4H-chromen-4-one hydrochloride;2-morpholin-4-yl-8-phenylchromen-4-one,hydrochloride;LY-294,002 hydrochloride, 98%, selective inhibitor of PI 3-kinase
CBNumber
CB8972820
Molecular Formula
C19H18ClNO3
Formula Weight
343.80412
MOL File
934389-88-5.mol
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LY 294002 Property

storage temp. 
2-8°C
solubility 
DMSO: >5mg/mL
form 
solid
color 
white to off-white
biological source
microbial (Staphylococcus roseus)
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Safety

WGK Germany 
3
HS Code 
29349990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
L9908
Product name
LY-294,002 hydrochloride
Purity
solid, ≥98% (HPLC)
Packaging
1mg
Price
$76.2
Updated
2025/07/31
Sigma-Aldrich
Product number
L9908
Product name
LY-294,002 hydrochloride
Purity
solid, ≥98% (HPLC)
Packaging
5mg
Price
$186.2
Updated
2025/07/31
TRC
Product number
L503113
Product name
LY-294,002 hydrochloride
Packaging
100mg
Price
$395
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
KIN0002442
Product name
LY 294002 HYDROCHLORIDE
Purity
95.00%
Packaging
5MG
Price
$500.96
Updated
2021/12/16
AK Scientific
Product number
0286AQ
Product name
LY-294,002 hydrochloride
Packaging
5mg
Price
$240
Updated
2021/12/16
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LY 294002 Chemical Properties,Usage,Production

Uses

LY 294002 Hydrochloride is a highly selective inhibitor of Phosphatidylinositol 3-kinase (PI3K). It is a salt analogue of LY 294002 (L486590).

General Description

LY-294,002 hydrochloride is a derivative of the flavonoid, quercetin and elicits higher inhibition on the enzyme phosphoinositide 3-kinase (PI3K). LY-294,002 inhibits nuclear factor kappa B signaling in macrophages. It elevates expression of autophagosomal protein LC3 and promotes apoptosis in gastric and nasopharyngeal cancer cells. LY-294,002 modulates action potential repolarization and improves myocyte contractility.

Biological Activity

Specific cell permeable phosphatidylinositol 3-kinase inhibitor.

in vivo

LY294002 hydrochloride (10, 25, 50, 75 mg/kg; i.p.; twice weekly; for 4 weeks) significantly reduces mean NPC tumor burden in a dose-dependent manner. LY294002 (10, 25 mg/kg) is less effective in decreasing tumor burden[4].
LY294002 hydrochloride (1.2 mg/kg per day; i.p.; for 14 days) prevents Leptin (60 ug/kg)-induced adverse effects on spermatozoa in Sprague-Dawley rats[5].

Animal Model:Athymic nude mice (6-8 weeks) with CNE-2Z xenograft[4]
Dosage:10 mg/kg, 25 mg/kg, 50 mg/kg, and 75 mg/kg
Administration:IP; twice weekly, for 4 weeks
Result:Mean Nasopharyngeal carcinoma (NPC) tumor burden was remarkably decreased in a dose-dependent manner.

IC 50

CK2: 0.098 μM (IC50); CK2α2: 3.869 μM (IC50)

storage

Room temperature

LY 294002 Preparation Products And Raw materials

Raw materials

Preparation Products

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LY 294002 Suppliers

China 56 India 1 Switzerland 1 United Kingdom 3 United States 6 Global 67
TargetMol Chemicals Inc.
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+1-781-999-5354; +17819995354
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marketing@targetmol.com
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United States
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Aladdin Scientific
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Email
tp@aladdinsci.com
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United States
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57505
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TargetMol Chemicals Inc.
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+1-781-999-5354;
Email
support@targetmol.com
Country
United States
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39035
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58
LC Laboratories
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United States
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Riedel-de Haen AG
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United States
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Santa Cruz Biotechnology, Inc.
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scbt@scbt.com
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United States
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3597
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934389-88-5, LY 294002Related Search:


  • LY 294002, Hydrochloride Salt, >99%
  • LY 294002, HYDROCHLORIDE SALT
  • LY-294,002 hydrochloride, 98%, selective inhibitor of PI 3-kinase
  • LY-294,002 hydrochloride, ≥98% (HPLC)
  • 2-morpholin-4-yl-8-phenylchromen-4-one,hydrochloride
  • 2-morpholino-8-phenyl-4H-chromen-4-one hydrochloride
  • LY-294002 hydrochloride, 10 mM in DMSO
  • LY-294,002 hydrochloride【L9908】
  • 2-Morpholin-4-yl-8-phenyl-4H-chromen-4-one HCl
  • 934389-88-5
  • C19H17NO3HCl